2021
PD-L1 (Programmed Death Ligand 1) Regulates T-Cell Differentiation to Control Adaptive Venous Remodeling
Matsubara Y, Gonzalez L, Kiwan G, Liu J, Langford J, Gao M, Gao X, Taniguchi R, Yatsula B, Furuyama T, Matsumoto T, Komori K, Mori M, Dardik A. PD-L1 (Programmed Death Ligand 1) Regulates T-Cell Differentiation to Control Adaptive Venous Remodeling. Arteriosclerosis Thrombosis And Vascular Biology 2021, 41: 2909-2922. PMID: 34670406, PMCID: PMC8664128, DOI: 10.1161/atvbaha.121.316380.Peer-Reviewed Original ResearchConceptsPD-L1AVF maturationPD-L1 activityVenous remodelingT cellsL1 antibodyArteriovenous fistulaNude miceMouse aortocaval fistula modelEnd-stage renal diseaseT helper type 2 cellsT helper type 1 (Th1) cellsPrimary success rateSmooth muscle cell proliferationRegulatory T cellsT cell activityT-cell transferAortocaval fistula modelPreferred vascular accessVascular wall thickeningM1-type macrophagesM2-type macrophagesPotential therapeutic targetMuscle cell proliferationType 1 cellsInhibition of T-Cells by Cyclosporine A Reduces Macrophage Accumulation to Regulate Venous Adaptive Remodeling and Increase Arteriovenous Fistula Maturation
Matsubara Y, Kiwan G, Liu J, Gonzalez L, Langford J, Gao M, Gao X, Taniguchi R, Yatsula B, Furuyama T, Matsumoto T, Komori K, Dardik A. Inhibition of T-Cells by Cyclosporine A Reduces Macrophage Accumulation to Regulate Venous Adaptive Remodeling and Increase Arteriovenous Fistula Maturation. Arteriosclerosis Thrombosis And Vascular Biology 2021, 41: e160-e174. PMID: 33472405, PMCID: PMC7904667, DOI: 10.1161/atvbaha.120.315875.Peer-Reviewed Original ResearchConceptsVascular wall thickeningT helper type 1 (Th1) cellsSuccessful AVF maturationAVF maturationRegulatory T cellsMacrophage accumulationT cellsType 1 cellsArteriovenous fistulaVenous remodelingWall thickeningMouse aortocaval fistula modelT helper type 2T helper type 2 cellsAdaptive remodelingM2 macrophage accumulationPrimary success rateAortocaval fistula modelArteriovenous fistula maturationPreferred vascular accessAnti-inflammatory macrophagesT cell functionWild-type miceEffect of CsAType 2 cells
2020
Activation of EphrinB2 Signaling Promotes Adaptive Venous Remodeling in Murine Arteriovenous Fistulae
Wang T, Liu J, Liu H, Lee SR, Gonzalez L, Gorecka J, Shu C, Dardik A. Activation of EphrinB2 Signaling Promotes Adaptive Venous Remodeling in Murine Arteriovenous Fistulae. Journal Of Surgical Research 2020, 262: 224-239. PMID: 33039109, PMCID: PMC8024410, DOI: 10.1016/j.jss.2020.08.071.Peer-Reviewed Original ResearchConceptsEndothelial nitric oxide synthasePhosphorylation of EphrinB2AVF maturationNitric oxide synthaseArteriovenous fistulaVenous remodelingEphB4-FcOxide synthaseEndothelial cell functionEndothelial cell tube formationExtracellular signal-regulated kinases 1/2Murine arteriovenous fistulaSignal-regulated kinases 1/2Cell tube formationAortocaval fistulaHuman endothelial cellsVascular accessExpression of ephrinB2Endothelial cell culture mediumDay 7FistulaEndothelial cellsArterial identityCell functionTube formationAltered hemodynamics during arteriovenous fistula remodeling leads to reduced fistula patency in female mice
Kudze T, Ono S, Fereydooni A, Gonzalez L, Isaji T, Hu H, Yatsula B, Taniguchi R, Koizumi J, Nishibe T, Dardik A. Altered hemodynamics during arteriovenous fistula remodeling leads to reduced fistula patency in female mice. JVS Vascular Science 2020, 1: 42-56. PMID: 32754721, PMCID: PMC7402599, DOI: 10.1016/j.jvssci.2020.03.001.Peer-Reviewed Original ResearchInfrarenal inferior vena cavaArteriovenous fistulaFemale miceMale miceHuman AVF maturationAVF maturationAVF patencyVascular cell adhesion molecule-1Superior long-term outcomesEndothelial nitric oxide synthaseCell adhesion molecule-1Male C57BL/6 miceLong-term outcomesInferior vena cavaNitric oxide synthaseAdhesion molecule-1Krüppel-like factor 2Significant differencesSex-specific differential expressionMessenger RNAAVF remodelingAVF utilizationFistula utilizationAortocaval fistulaFistula patency
2019
Molecular Targets for Improving Arteriovenous Fistula Maturation and Patency.
Gorecka J, Fereydooni A, Gonzalez L, Lee SR, Liu S, Ono S, Xu J, Liu J, Taniguchi R, Matsubara Y, Gao X, Gao M, Langford J, Yatsula B, Dardik A. Molecular Targets for Improving Arteriovenous Fistula Maturation and Patency. Vascular Investigation And Therapy 2019, 2: 33-41. PMID: 31608322, PMCID: PMC6788624, DOI: 10.4103/vit.vit_9_19.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAVF maturationAVF failureArteriovenous fistulaOutward remodelingNeointimal hyperplasiaVenous wallErythropoietin-producing hepatocellular carcinoma (Eph) receptorsWall thickeningEnd-stage renal diseaseAdhesion molecule upregulationReliable vascular accessArteriovenous fistula maturationPotential treatment strategyPotential therapeutic targetPrevalence of chronicGrowth factor secretionFistula environmentFistula successExtracellular matrix remodelingRenal diseaseFistula maturationFunctional fistulaHemodialysis accessVascular accessFistula creation