FXR agonists INT‐787 and OCA increase RECK and inhibit liver steatosis and inflammation in diet‐induced ob/ob mouse model of NASH
Di Pasqua L, Cagna M, Palladini G, Croce A, Cadamuro M, Fabris L, Perlini S, Adorini L, Ferrigno A, Vairetti M. FXR agonists INT‐787 and OCA increase RECK and inhibit liver steatosis and inflammation in diet‐induced ob/ob mouse model of NASH. Liver International 2023, 44: 214-227. PMID: 37904642, DOI: 10.1111/liv.15767.Peer-Reviewed Original ResearchConceptsNon-alcoholic steatohepatitisHigh-fat dietOb/ob mouse modelObeticholic acidAgonist obeticholic acidSerum alanine transaminaseAlanine transaminaseMMP-2MMP-9Mouse modelCollagen depositionHepatic ischaemia/reperfusion injuryFarnesoid X receptor agonist obeticholic acidControl dietFXR agonist obeticholic acidIschaemia/reperfusion injuryHepatic stellate cell activationMMP-9 activityStellate cell activationMMP-2 expressionΑ-SMA levelsOCA administrationHFD groupReperfusion injuryLiver steatosis