2017
Narrow-band imaging versus white light versus mapping biopsy for gastric intestinal metaplasia: a prospective blinded trial
Buxbaum JL, Hormozdi D, Dinis-Ribeiro M, Lane C, Dias-Silva D, Sahakian A, Jayaram P, Pimentel-Nunes P, Shue D, Pepper M, Cho D, Laine L. Narrow-band imaging versus white light versus mapping biopsy for gastric intestinal metaplasia: a prospective blinded trial. Gastrointestinal Endoscopy 2017, 86: 857-865. PMID: 28366441, DOI: 10.1016/j.gie.2017.03.1528.Peer-Reviewed Original ResearchConceptsGastric intestinal metaplasiaDetection of GIMNarrow-band imagingHD-WLMapping biopsyIntestinal metaplasiaHigh-definition white light endoscopyProportion of patientsProspective blinded trialGastric cancer precursorsGastric cancer riskWhite light endoscopyNBI examinationPrimary outcomeUpper endoscopyHigher proportionBlinded trialCancer precursorsBiopsy specimensMedian numberSecond endoscopistGastric cancerCancer riskBiopsyPatients
2014
Low Adherence to Helicobacter pylori Testing in Hospitalized Patients with Bleeding Peptic Ulcer Disease
Kim JJ, Lee JS, Olafsson S, Laine L. Low Adherence to Helicobacter pylori Testing in Hospitalized Patients with Bleeding Peptic Ulcer Disease. Helicobacter 2014, 19: 98-104. PMID: 24617668, DOI: 10.1111/hel.12114.Peer-Reviewed Original ResearchConceptsH. pylori testingProportion of patientsIndex hospitalizationHospitalized patientsConsecutive hospitalized patientsPeptic ulcer diseaseHelicobacter pylori testingInitial endoscopyUlcer diseaseSerologic testingSingle centerEndoscopy databaseSociety guidelinesGastric ulcerLow adherencePatientsUlcersMultivariate analysisHelicobacter pyloriHospitalizationDirect testingBiopsyTestingEndoscopyPylori
2008
Intragastric pH With Oral vs Intravenous Bolus Plus Infusion Proton-Pump Inhibitor Therapy in Patients With Bleeding Ulcers
Laine L, Shah A, Bemanian S. Intragastric pH With Oral vs Intravenous Bolus Plus Infusion Proton-Pump Inhibitor Therapy in Patients With Bleeding Ulcers. Gastroenterology 2008, 134: 1836-1841. PMID: 18423628, DOI: 10.1053/j.gastro.2008.03.006.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralDrug Administration ScheduleDuodenal UlcerDuodenoscopyFemaleGastric AcidGastric Acidity DeterminationGastroscopyHumansHydrogen-Ion ConcentrationInfusions, IntravenousMaleMiddle AgedPeptic Ulcer HemorrhageProton Pump InhibitorsStomach UlcerTime FactorsTreatment OutcomeConceptsProton pump inhibitor therapyOral PPIIntravenous PPIInhibitor therapyConfidence intervalsStudy periodFrequent oral dosingHigh-risk stigmataSimilar antisecretory effectIntravenous lansoprazoleOral lansoprazolePPI therapyAntisecretory effectWide confidence intervalsIntragastric pHIntravenous bolusBleeding ulcersOral dosingPatientsBaseline pHUlcersAbstractTextTherapyAIMSBolus
1999
A randomized trial comparing the effect of rofecoxib, a cyclooxygenase 2–specific inhibitor, with that of ibuprofen on the gastroduodenal mucosa of patients with osteoarthritis
Laine L, Harper S, Simon T, Bath R, Johanson J, Schwartz H, Stern S, Quan H, Bolognese J, Group F. A randomized trial comparing the effect of rofecoxib, a cyclooxygenase 2–specific inhibitor, with that of ibuprofen on the gastroduodenal mucosa of patients with osteoarthritis. Gastroenterology 1999, 117: 776-783. PMID: 10500058, DOI: 10.1016/s0016-5085(99)70334-3.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCyclooxygenase 2Cyclooxygenase 2 InhibitorsCyclooxygenase InhibitorsDouble-Blind MethodDuodenal UlcerFemaleGastric MucosaGastroscopyHumansIbuprofenIntestinal MucosaIsoenzymesLactonesMaleMembrane ProteinsMiddle AgedOsteoarthritisProstaglandin-Endoperoxide SynthasesStomach UlcerSulfonesConceptsUlcer ratesGastroduodenal ulcersCOX-2 specific inhibitionSymptoms of osteoarthritisNonspecific COX inhibitorNormal gastrointestinal tractTreatment of patientsBaseline endoscopyGastroduodenal ulcerationPlacebo groupCumulative incidenceOsteoarthritis patientsGastroduodenal mucosaWeek 12COX inhibitorsMucosal integrityCOX-2Gastrointestinal tractInflammatory sitesProstaglandin productionDoses 2AbstractTextEffective doseUlcersPatients
1998
Evaluation of the FlexSure HP whole blood antibody test for diagnosis of Helicobacter pylori infection
Sadowski D, Cohen H, Laine L, Greenberg P, Goldstein J, Mihalov M, Cutler A. Evaluation of the FlexSure HP whole blood antibody test for diagnosis of Helicobacter pylori infection. The American Journal Of Gastroenterology 1998, 93: ajg1998490. PMID: 9820383, DOI: 10.1111/j.1572-0241.1998.00604.x.Peer-Reviewed Original ResearchConceptsHelicobacter pylori infectionRapid urease testPylori infectionWhole blood testH. pyloriWhole bloodBlood testsUrease testPositive rapid urease testBlood antibody testH. pylori infectionProton pump inhibitorsH. pylori diagnosisDetection of antibodiesUpper endoscopyStudy enrollmentPump inhibitorsGastric biopsiesIgG antibodiesSerum testAntibody testOffice testsAntral tissueBacterial infectionsPatients
1997
Prospective comparison of H&E, Giemsa, and Genta stains for the diagnosis of Helicobacter pylori
Laine L, Lewin D, Naritoku W, Cohen H. Prospective comparison of H&E, Giemsa, and Genta stains for the diagnosis of Helicobacter pylori. Gastrointestinal Endoscopy 1997, 45: 463-467. PMID: 9199901, DOI: 10.1016/s0016-5107(97)70174-3.Peer-Reviewed Original Research
1996
The influence of warming on rapid urease test results: a prospective evaluation
Laine L, Estrada R, Lewin D, Cohen H. The influence of warming on rapid urease test results: a prospective evaluation. Gastrointestinal Endoscopy 1996, 44: 429-432. PMID: 8905363, DOI: 10.1016/s0016-5107(96)70094-9.Peer-Reviewed Original ResearchA prospective outcome study of patients with clot in an ulcer and the effect of irrigation
Laine L, Stein C, Sharma V. A prospective outcome study of patients with clot in an ulcer and the effect of irrigation. Gastrointestinal Endoscopy 1996, 43: 107-110. PMID: 8635701, DOI: 10.1016/s0016-5107(06)80109-4.Peer-Reviewed Original ResearchConceptsUpper gastrointestinal bleedingEndoscopic therapyVisible vesselActive bleedingFurther bleedingGastrointestinal bleedingHemostatic therapyAdherent clotHigh-risk stigmataLow-risk findingsProspective outcome studyObservation of patientsInitial endoscopyEndoscopic findingsProspective studyExcellent outcomesUlcer baseBleedingClean baseOutcome studiesVigorous irrigationPatientsAppropriate managementVariable prevalenceTherapy
1994
Lack of uniformity in evaluation of endoscopic prognostic features of bleeding ulcers
Laine L, Freeman M, Cohen H. Lack of uniformity in evaluation of endoscopic prognostic features of bleeding ulcers. Gastrointestinal Endoscopy 1994, 40: 411-417. PMID: 7926529, DOI: 10.1016/s0016-5107(94)70202-0.Peer-Reviewed Original ResearchConceptsLevel of agreementUpper gastrointestinal endoscopyType of procedureBrief teaching sessionUlcer stigmataEndoscopic featuresPrognostic featuresRecent hemorrhageUlcer appearanceGastrointestinal endoscopyAmerican CollegeEndoscopic experienceAdditional slidesUlcersTeaching sessionsEndoscopistsYears of experienceShort teaching sessionEndoscopyCorrect answersMonthsLack of uniformitySessionsStigmaTotal number
1992
Endoscopic therapy for acute nonvariceal upper gastrointestinal hemorrhage: A meta-analysis
Cook D, Guyatt G, Salena B, Laine L. Endoscopic therapy for acute nonvariceal upper gastrointestinal hemorrhage: A meta-analysis. Gastroenterology 1992, 102: 139-148. PMID: 1530782, DOI: 10.1016/0016-5085(92)91793-4.Peer-Reviewed Original ResearchConceptsAcute nonvariceal upper gastrointestinal hemorrhageNonvariceal upper gastrointestinal hemorrhageUpper gastrointestinal hemorrhageEndoscopic hemostatic therapyEndoscopic therapyGastrointestinal hemorrhageHemostatic therapyEndoscopic treatmentFlat pigmented spotUpper gastrointestinal bleedingDuplicate independent reviewForm of therapyEnglish-language literatureActive bleedingFurther bleedingGastrointestinal bleedingEndoscopic featuresInjection therapyAdherent clotRelevant trialsSurgery ratesVisible vesselLaser therapyBleedingTherapy
1989
Campylobacter pylori in alcoholic hemorrhagic “gastritis”
Laine L, Marin-Sorensen M, Weinstein W. Campylobacter pylori in alcoholic hemorrhagic “gastritis”. Digestive Diseases And Sciences 1989, 34: 677-680. PMID: 2785447, DOI: 10.1007/bf01540337.Peer-Reviewed Original ResearchConceptsSubepithelial hemorrhageCampylobacter pyloriInflammatory cell scoresInflammatory cell densityMucosal hemorrhageEdema scoreAlcoholic patientsHistologic abnormalitiesMononuclear cellsBiopsy specimensEpithelial abnormalitiesHemorrhagic lesionsNeutrophil scoreHemorrhage scoreHistologic scoringHemorrhageMucosaBiopsyBiopsy slidesMean scoreScoresPresence of CPPyloriAbnormalitiesCell density
1988
Histology of alcoholic hemorrhagic “gastritis”: A prospective evaluation
Laine L, Weinstein W. Histology of alcoholic hemorrhagic “gastritis”: A prospective evaluation. Gastroenterology 1988, 94: 1254-1262. PMID: 3258836, DOI: 10.1016/0016-5085(88)90661-0.Peer-Reviewed Original ResearchConceptsSubepithelial hemorrhageAlcoholic patientsHemorrhagic gastritisBiopsy specimensProminent inflammatory cell infiltrationFoveolar regionInflammatory cell infiltrateInflammatory cell infiltrationGastrointestinal bleedingUpper endoscopyCell infiltrateMucosal edemaProspective evaluationAdjacent mucosaBarrett's esophagusCell infiltrationGastric biopsiesHemorrhagic lesionsTarget lesionsHistologic natureHemorrhage scoreHistologic scoringBiopsy siteHemorrhagePatientsPrevalence ofCampylobacter pylori and association with antral mucosal histology in subjects with and without upper gastrointestinal symptoms
Pettross C, Appleman M, Cohen H, Valenzuela J, Chandrasoma P, Laine L. Prevalence ofCampylobacter pylori and association with antral mucosal histology in subjects with and without upper gastrointestinal symptoms. Digestive Diseases And Sciences 1988, 33: 649-653. PMID: 3371136, DOI: 10.1007/bf01540425.Peer-Reviewed Original ResearchConceptsUpper gastrointestinal symptomsGastrointestinal symptomsAsymptomatic volunteersNormal endoscopic findingsRoutine endoscopic evaluationPeptic ulcer diseaseYoung asymptomatic adultsAntral inflammationAntral gastritisEndoscopic findingsEndoscopic evaluationMucosal histologyUlcer diseaseAsymptomatic adultsChronic gastritisEndoscopic examinationHistological examinationPatientsVolunteersGastritisMucosaSymptomsExaminationAssociationBiopsySubepithelial hemorrhages and erosions of human stomach
Laine L, Weinstein W. Subepithelial hemorrhages and erosions of human stomach. Digestive Diseases And Sciences 1988, 33: 490-503. PMID: 3280275, DOI: 10.1007/bf01536037.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsGastric MucosaGastritisGastrointestinal HemorrhageGastroscopyHumansStomach DiseasesTerminology as Topic