2009
Endoscopy of the esophagus in gastroesophageal reflux disease: are we losing sight of symptoms? Another perspective
Sharma P, Chey W, Hunt R, Laine L, Malfertheiner P, Wani S. Endoscopy of the esophagus in gastroesophageal reflux disease: are we losing sight of symptoms? Another perspective. Diseases Of The Esophagus 2009, 22: 461-466. PMID: 19191851, DOI: 10.1111/j.1442-2050.2008.00934.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGastroesophageal reflux diseaseGERD-like symptomsSuppressive therapyReflux diseaseAcid suppressive therapyErosive reflux diseaseProspective multicenter studyCommon chronic disorderPrimary care physiciansPrimary care settingSymptom-based classificationSymptom-based diagnosisHuge economic burdenInternational Consensus GroupErosive esophagitisGERD patientsTroublesome symptomsEmpiric trialPartial responseComplete responseCare physiciansImpaired qualityMulticenter studyBarrett's esophagusChronic disorders
2008
Intragastric pH With Oral vs Intravenous Bolus Plus Infusion Proton-Pump Inhibitor Therapy in Patients With Bleeding Ulcers
Laine L, Shah A, Bemanian S. Intragastric pH With Oral vs Intravenous Bolus Plus Infusion Proton-Pump Inhibitor Therapy in Patients With Bleeding Ulcers. Gastroenterology 2008, 134: 1836-1841. PMID: 18423628, DOI: 10.1053/j.gastro.2008.03.006.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralDrug Administration ScheduleDuodenal UlcerDuodenoscopyFemaleGastric AcidGastric Acidity DeterminationGastroscopyHumansHydrogen-Ion ConcentrationInfusions, IntravenousMaleMiddle AgedPeptic Ulcer HemorrhageProton Pump InhibitorsStomach UlcerTime FactorsTreatment OutcomeConceptsProton pump inhibitor therapyOral PPIIntravenous PPIInhibitor therapyConfidence intervalsStudy periodFrequent oral dosingHigh-risk stigmataSimilar antisecretory effectIntravenous lansoprazoleOral lansoprazolePPI therapyAntisecretory effectWide confidence intervalsIntragastric pHIntravenous bolusBleeding ulcersOral dosingPatientsBaseline pHUlcersAbstractTextTherapyAIMSBolus
2000
Review article: potential gastrointestinal effects of long‐term acid suppression with proton pump inhibitors
Laine, Ahnen, Mcclain, Solcia, Walsh. Review article: potential gastrointestinal effects of long‐term acid suppression with proton pump inhibitors. Alimentary Pharmacology & Therapeutics 2000, 14: 651-668. PMID: 10848649, DOI: 10.1046/j.1365-2036.2000.00768.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsProton pump inhibitor useProton pump inhibitorsLong-term acid suppressionGastric acid suppressionAcid suppressionPump inhibitorsInhibitor useBacterial overgrowthEnteric infectionsGastric adenocarcinomaHigh-dose proton pump inhibitorsCarcinoid formationLong-term proton pump inhibitor useEnterochromaffin-like cell hyperplasiaAdverse effectsChronic acid suppressionImportant clinical sequelaeLong-term protonGastrointestinal adverse effectsMalabsorption of fatVitamin B12 levelsCommon clinical problemH. pylori infectionVitamin B12 concentrationsGastric bacterial overgrowth