2005
Early Heartburn Relief With Proton Pump Inhibitors: A Systematic Review and Meta-analysis of Clinical Trials
McQuaid KR, Laine L. Early Heartburn Relief With Proton Pump Inhibitors: A Systematic Review and Meta-analysis of Clinical Trials. Clinical Gastroenterology And Hepatology 2005, 3: 553-563. PMID: 15952097, DOI: 10.1016/s1542-3565(05)00023-6.Peer-Reviewed Original ResearchConceptsHeartburn reliefPPI therapyDay 1Clinical trialsSystematic reviewDouble-dose therapyEfficacy of PPIDays of therapyProton pump inhibitorsShort-term treatmentFirst placeboPPI doseMost patientsPooled proportionSustained reliefSymptom reliefRandomized comparisonPump inhibitorsInclusion criteriaPatientsMeta-AnalysisTherapyAbstractTextFirst dayHeartburn
1999
Once-daily therapy for H. pylori infection: a randomized comparison of four regimens
Laine L, Estrada R, Trujillo M, Cheybani K, Yeramian P, Smith S, Neil G. Once-daily therapy for H. pylori infection: a randomized comparison of four regimens. The American Journal Of Gastroenterology 1999, 94: 962. PMID: 10201465, DOI: 10.1111/j.1572-0241.1999.995_r.x.Peer-Reviewed Original ResearchConceptsH. pylori infectionEradication ratePylori infectionExtended-release formulationDaily therapyBreath testDaily triple therapyHigh-dose omeprazoleTreat eradication ratesCompletion of therapyHelicobacter pylori infectionRepeat breath testStudy medicationTriple therapyEndoscopic biopsyRandomized comparisonLack of complianceTherapyPilot studyInfectionFurther studiesClarithromycinOmamDaysSubjects
1997
Randomized comparison of saline injection vs. Bipolar electrocoagulation (BPEC) for treatment of patients with high-risk bleeding ulcers
Laine L, Stein C, Estrada R. Randomized comparison of saline injection vs. Bipolar electrocoagulation (BPEC) for treatment of patients with high-risk bleeding ulcers. Gastrointestinal Endoscopy 1997, 45: ab94. DOI: 10.1016/s0016-5107(97)80281-7.Peer-Reviewed Original Research
1996
Randomized comparison of ligation versus ligation plus sclerotherapy in patients with bleeding esophageal varices
Laine L, Stein C, Sharma V. Randomized comparison of ligation versus ligation plus sclerotherapy in patients with bleeding esophageal varices. Gastroenterology 1996, 110: 529-533. PMID: 8566601, DOI: 10.1053/gast.1996.v110.pm8566601.Peer-Reviewed Original ResearchConceptsEsophageal varicesVariceal eradicationCombined therapyTreatment sessionsMajor bleedingMean followEndoscopic sclerotherapyHospital daysRepeat endoscopyRandomized comparisonSclerotherapyVaricesPatientsAbstractTextTherapyMore sessionsLigationEradicationComplicationsSignificant differencesAIMSTreatmentSessionsGreater timeBleeding
1995
Randomized comparison of normal saline injection vs. bipolar electrocoagulation in high-risk patients with bleeding ulcers
Stein C, Laine L. Randomized comparison of normal saline injection vs. bipolar electrocoagulation in high-risk patients with bleeding ulcers. Gastrointestinal Endoscopy 1995, 41: 371. DOI: 10.1016/s0016-5107(05)80340-2.Peer-Reviewed Original Research
1994
Prospective, randomized comparison of disposable and reusable biopsy forceps in gastrointestinal endoscopy
Yang R, Naritoku W, Laine L. Prospective, randomized comparison of disposable and reusable biopsy forceps in gastrointestinal endoscopy. Gastrointestinal Endoscopy 1994, 40: 671-674. PMID: 7859962, DOI: 10.1016/s0016-5107(94)70107-5.Peer-Reviewed Original Research