2022
Vonoprazan Versus Lansoprazole for Healing and Maintenance of Healing of Erosive Esophagitis: A Randomized Trial
Laine L, DeVault K, Katz P, Mitev S, Lowe J, Hunt B, Spechler S. Vonoprazan Versus Lansoprazole for Healing and Maintenance of Healing of Erosive Esophagitis: A Randomized Trial. Gastroenterology 2022, 164: 61-71. PMID: 36228734, DOI: 10.1053/j.gastro.2022.09.041.Peer-Reviewed Original ResearchConceptsMaintenance of healingProton pump inhibitorsErosive esophagitisSecondary analysisD esophagitisPrimary analysisEnd pointPotassium-competitive acid blocker vonoprazanHeartburn-free daysSevere erosive esophagitisMainstay of treatmentPrimary end pointSecondary end pointsPotent acid inhibitionPPI lansoprazolePump inhibitorsEsophagitisNoninferiority comparisonVonoprazanWeek 2Healing phaseAbstractTextPatientsLansoprazoleSuperiority analysis
2021
Ozanimod as Induction and Maintenance Therapy for Ulcerative Colitis
Sandborn WJ, Feagan BG, D'Haens G, Wolf DC, Jovanovic I, Hanauer SB, Ghosh S, Petersen A, Hua SY, Lee JH, Charles L, Chitkara D, Usiskin K, Colombel JF, Laine L, Danese S. Ozanimod as Induction and Maintenance Therapy for Ulcerative Colitis. New England Journal Of Medicine 2021, 385: 1280-1291. PMID: 34587385, DOI: 10.1056/nejmoa2033617.Peer-Reviewed Original ResearchConceptsActive ulcerative colitisMaintenance therapyUlcerative colitisClinical remissionEnd pointClinical responseCohort 2Cohort 1Selective sphingosine-1-phosphate receptor modulatorSphingosine-1-phosphate receptor modulatorsElevated liver aminotransferase levelsKey secondary end pointLiver aminotransferase levelsPlacebo-controlled trialPrimary end pointSecondary end pointsPercentage of patientsDouble-blind mannerInflammatory bowel diseaseSame daily doseIncidence of infectionHistologic end pointsMayo scoreUnderwent randomizationAminotransferase levels
2020
Use of Fecal Occult Blood Testing as a Diagnostic Tool for Clinical Indications: A Systematic Review and Meta-Analysis.
Lee MW, Pourmorady JS, Laine L. Use of Fecal Occult Blood Testing as a Diagnostic Tool for Clinical Indications: A Systematic Review and Meta-Analysis. The American Journal Of Gastroenterology 2020, 115: 662-670. PMID: 31972617, DOI: 10.14309/ajg.0000000000000495.Peer-Reviewed Original ResearchConceptsFecal occult blood testIron deficiency anemiaSensitivity of FOBTAcute diarrheaClinical indicationsSystematic reviewFecal occult blood testingDiagnostic testsSpecific gastrointestinal symptomsOccult blood testingPrimary end pointOccult blood testColorectal cancer screeningPositive stool cultureRisk of biasQUADAS-2 toolGastrointestinal symptomsAdult patientsEndoscopic evaluationUlcerative colitisEndoscopic activityBlood testsIdentifiable causeStool culturesBlood testing
2013
Aggressive Hydration With Lactated Ringer's Solution Reduces Pancreatitis After Endoscopic Retrograde Cholangiopancreatography
Buxbaum J, Yan A, Yeh K, Lane C, Nguyen N, Laine L. Aggressive Hydration With Lactated Ringer's Solution Reduces Pancreatitis After Endoscopic Retrograde Cholangiopancreatography. Clinical Gastroenterology And Hepatology 2013, 12: 303-307.e1. PMID: 23920031, PMCID: PMC3879172, DOI: 10.1016/j.cgh.2013.07.026.Peer-Reviewed Original ResearchConceptsEndoscopic retrograde cholangiopancreatographyPost-ERCP pancreatitisAggressive hydrationStandard hydrationVolume overloadEpigastric painRetrograde cholangiopancreatographyRinger's solutionFirst-time endoscopic retrograde cholangiopancreatographyVisual analogue pain scoreEnd pointPilot studyAggressive intravenous hydrationAnalog pain scoresIncidence of pancreatitisPrimary end pointSecondary end pointsCommon serious complicationLactated Ringer's solutionPeriprocedural hydrationIntravenous hydrationPain scoresSerious complicationsSerum levelsPancreatitis
2010
Randomized Trial of Urgent vs. Elective Colonoscopy in Patients Hospitalized With Lower GI Bleeding
Laine L, Shah A. Randomized Trial of Urgent vs. Elective Colonoscopy in Patients Hospitalized With Lower GI Bleeding. The American Journal Of Gastroenterology 2010, 105: 2636. PMID: 20648004, DOI: 10.1038/ajg.2010.277.Peer-Reviewed Original ResearchConceptsLower GI bleedingElective colonoscopyUpper endoscopyUrgent colonoscopyGI bleedingBlood pressureHeart rateUpper gastrointestinal sourceUpper GI sourceUrgent upper endoscopyPrimary end pointDuration of hospitalizationSystolic blood pressureUnits of bloodEligible patientsUrgent groupElective groupHospital daysOrthostatic changesBlood transfusionClinical outcomesRandomized trialsHospital chargesVs. 5Gastrointestinal source
2009
Methodology for Randomized Trials of Patients With Nonvariceal Upper Gastrointestinal Bleeding: Recommendations From an International Consensus Conference
Laine L, Spiegel B, Rostom A, Moayyedi P, Kuipers EJ, Bardou M, Sung J, Barkun AN. Methodology for Randomized Trials of Patients With Nonvariceal Upper Gastrointestinal Bleeding: Recommendations From an International Consensus Conference. The American Journal Of Gastroenterology 2009, 105: ajg2009702. PMID: 20029415, DOI: 10.1038/ajg.2009.702.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsNonvariceal upper gastrointestinal bleedingUpper gastrointestinal bleedingPrimary end pointInternational Consensus ConferenceGastrointestinal bleedingRandomized trialsConsensus conferenceEnd pointPrimary assessmentManagement of patientsType of lesionPlacebo/Protocol populationRepeat endoscopyLarge trialsRandomization scheduleInclusion criteriaPatientsSmall studyCurrent standard practiceSubsequent interventionsBleedingLiterature searchSample size calculationConservative approach
2008
Endoscopic Therapy for Bleeding Ulcers: An Evidence-Based Approach Based on Meta-Analyses of Randomized Controlled Trials
Laine L, McQuaid KR. Endoscopic Therapy for Bleeding Ulcers: An Evidence-Based Approach Based on Meta-Analyses of Randomized Controlled Trials. Clinical Gastroenterology And Hepatology 2008, 7: 33-47. PMID: 18986845, DOI: 10.1016/j.cgh.2008.08.016.Peer-Reviewed Original ResearchConceptsEndoscopic therapyProton pump inhibitorsActive bleedingVisible vesselPump inhibitorsIntravenous proton pump inhibitorsAppropriate endoscopic treatmentNonbleeding visible vesselPrimary end pointSecond-look endoscopyEndoscopic hemostatic therapyRandomized Controlled TrialsEvidence-based approachPlacebo/Further bleedingHemostatic therapyInjection therapyControlled TrialsEndoscopic treatmentRandomized trialsBleeding ulcersSclerosant therapyReceptor antagonistBibliographic database searchBleeding
2005
Randomized, double-blind comparison of immediate-release omeprazole oral suspension versus intravenous cimetidine for the prevention of upper gastrointestinal bleeding in critically ill patients
Conrad SA, Gabrielli A, Margolis B, Quartin A, Hata JS, Frank WO, Bagin RG, Rock JA, Hepburn B, Laine L. Randomized, double-blind comparison of immediate-release omeprazole oral suspension versus intravenous cimetidine for the prevention of upper gastrointestinal bleeding in critically ill patients. Critical Care Medicine 2005, 33: 760-765. PMID: 15818102, DOI: 10.1097/01.ccm.0000157751.92249.32.Peer-Reviewed Original ResearchConceptsUpper gastrointestinal bleedingSignificant upper gastrointestinal bleedingGastrointestinal bleedingIll patientsIntravenous cimetidineOmeprazole suspensionMedian gastricChronic Health Evaluation (APACHE II) scoreTrial daysOral suspensionCimetidine treatment groupsDouble-blind trialPrimary end pointDouble-blind comparisonIntensive care unitAdditional risk factorsAcute PhysiologyProtocol populationCimetidine treatmentMedication dosesOrogastric tubeSignificant bleedingCare unitMechanical ventilationGastric aspirates
2000
Comparison of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis
Bombardier C, Laine L, Reicin A, Shapiro D, Burgos-Vargas R, Davis B, Day R, Ferraz M, Hawkey C, Hochberg M, Kvien T, Schnitzer T. Comparison of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis. New England Journal Of Medicine 2000, 343: 1520-1528. PMID: 11087881, DOI: 10.1056/nejm200011233432103.Peer-Reviewed Original ResearchMeSH KeywordsAdultArthritis, RheumatoidCardiovascular DiseasesCyclooxygenase 2Cyclooxygenase 2 InhibitorsCyclooxygenase InhibitorsDuodenal ObstructionFemaleGastric Outlet ObstructionGastrointestinal DiseasesGastrointestinal HemorrhageHumansIsoenzymesLactonesMaleMembrane ProteinsMiddle AgedNaproxenPeptic UlcerProportional Hazards ModelsProstaglandin-Endoperoxide SynthasesSulfonesConceptsUpper gastrointestinal eventsNonselective nonsteroidal antiinflammatory drugsGastrointestinal eventsRheumatoid arthritisCyclooxygenase-2Upper gastrointestinal toxicityPercent of patientsPrimary end pointOverall mortality rateNonsteroidal antiinflammatory drugsRate of deathYears of ageNonselective NSAID naproxenSelective inhibitorCardiovascular causesRofecoxib groupGastrointestinal toxicityNaproxen groupMyocardial infarctionSimilar efficacyAntiinflammatory drugsLower incidenceArthritisMortality ratePatients