2005
Randomized, double-blind comparison of immediate-release omeprazole oral suspension versus intravenous cimetidine for the prevention of upper gastrointestinal bleeding in critically ill patients
Conrad SA, Gabrielli A, Margolis B, Quartin A, Hata JS, Frank WO, Bagin RG, Rock JA, Hepburn B, Laine L. Randomized, double-blind comparison of immediate-release omeprazole oral suspension versus intravenous cimetidine for the prevention of upper gastrointestinal bleeding in critically ill patients. Critical Care Medicine 2005, 33: 760-765. PMID: 15818102, DOI: 10.1097/01.ccm.0000157751.92249.32.Peer-Reviewed Original ResearchConceptsUpper gastrointestinal bleedingSignificant upper gastrointestinal bleedingGastrointestinal bleedingIll patientsIntravenous cimetidineOmeprazole suspensionMedian gastricChronic Health Evaluation (APACHE II) scoreTrial daysOral suspensionCimetidine treatment groupsDouble-blind trialPrimary end pointDouble-blind comparisonIntensive care unitAdditional risk factorsAcute PhysiologyProtocol populationCimetidine treatmentMedication dosesOrogastric tubeSignificant bleedingCare unitMechanical ventilationGastric aspirates
1991
The Causes of Esophageal Symptoms in Human Immunodeficiency Virus Infection: A Prospective Study of 110 Patients
Bonacini M, Young T, Laine L. The Causes of Esophageal Symptoms in Human Immunodeficiency Virus Infection: A Prospective Study of 110 Patients. JAMA Internal Medicine 1991, 151: 1567-1572. DOI: 10.1001/archinte.1991.00400080067012.Peer-Reviewed Original ResearchHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionBlind brushingHerpes simplex virusViral cultureHistologic examinationVirus infectionCandida esophagitisEsophageal symptomsSimplex virusViral infectionPositive predictive valueDiagnosis of esophagitisEsophageal infectionsInfectious esophagitisViral esophagitisConsecutive patientsOral thrushOrogastric tubeEsophageal biopsiesProspective studyVirologic testingBiopsy specimensEsophageal brushingsEsophagitisThe causes of esophageal symptoms in human immunodeficiency virus infection. A prospective study of 110 patients.
Bonacini M, Young T, Laine L. The causes of esophageal symptoms in human immunodeficiency virus infection. A prospective study of 110 patients. JAMA Internal Medicine 1991, 151: 1567-72. PMID: 1651690, DOI: 10.1001/archinte.151.8.1567.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionBlind brushingHerpes simplex virusViral cultureHistologic examinationVirus infectionCandida esophagitisEsophageal symptomsSimplex virusViral infectionProspective clinical case studyUrban county hospitalPositive predictive valueDiagnosis of esophagitisEsophageal infectionsInfectious esophagitisViral esophagitisConsecutive patientsOral thrushOrogastric tubeEsophageal biopsiesProspective studyVirologic testingBiopsy specimens