2006
Systematic Review and Meta-analysis of Adverse Events of Low-dose Aspirin and Clopidogrel in Randomized Controlled Trials
McQuaid KR, Laine L. Systematic Review and Meta-analysis of Adverse Events of Low-dose Aspirin and Clopidogrel in Randomized Controlled Trials. The American Journal Of Medicine 2006, 119: 624-638. PMID: 16887404, DOI: 10.1016/j.amjmed.2005.10.039.Peer-Reviewed Original ResearchConceptsLow-dose aspirinAspirin/clopidogrelMajor GI bleedingMajor bleedingGI bleedingAdverse eventsIntracranial bleedingRelative riskSystematic reviewMajor bleeding episodesMajor gastrointestinal bleedingRelevant adverse eventsRisk of GIAbsolute risk increaseRandomized Controlled TrialsDay aspirinMajor GIBleeding episodesCardiovascular prophylaxisGastrointestinal bleedingAntiplatelet agentsControlled TrialsWeighted incidenceAbsolute riskClopidogrel
2002
Randomized trial of normal saline solution injection versus bipolar electrocoagulation for treatment of patients with high-risk bleeding ulcers: Is local tamponade enough?
Laine L, Estrada R. Randomized trial of normal saline solution injection versus bipolar electrocoagulation for treatment of patients with high-risk bleeding ulcers: Is local tamponade enough? Gastrointestinal Endoscopy 2002, 55: 6-10. PMID: 11756906, DOI: 10.1067/mge.2002.120390.Peer-Reviewed Original ResearchConceptsSaline solution injectionSaline solution groupNormal saline solutionBipolar electrocoagulationLocal tamponadeNonbleeding visible vesselIndependent risk factorSolution injectionSolution groupTreatment of patientsSaline solutionMajor bleedingActive bleedingEndoscopic injectionHospital daysStandard therapyUlcer sizeLack of injuryClinical evidenceVisible vesselRisk factorsEffective treatmentPatientsBleedingUlcers
1996
Nonsteroidal Anti-Inflammatory Drug Gastropathy
Laine L. Nonsteroidal Anti-Inflammatory Drug Gastropathy. Gastrointestinal Endoscopy Clinics Of North America 1996, 6: 489-504. PMID: 8803564, DOI: 10.1016/s1052-5157(18)30351-9.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGastrointestinal complicationsSubepithelial hemorrhageNonsteroidal anti-inflammatory drug gastropathyDevelopment of NSAIDUpper abdominal symptomsGastric outlet obstructionHalf of patientsPost-treatment biopsiesH. pylori infectionReactive gastritisAbdominal symptomsMajor bleedingMinor bleedingNSAID useUlcer complicationsGastrointestinal bleedingNSAID ingestionNSAID gastropathyOutlet obstructionDuodenal ulcerGastric erosionsHistologic gastritisGastric lesionsGastric ulcerPeptic ulcerRandomized comparison of ligation versus ligation plus sclerotherapy in patients with bleeding esophageal varices
Laine L, Stein C, Sharma V. Randomized comparison of ligation versus ligation plus sclerotherapy in patients with bleeding esophageal varices. Gastroenterology 1996, 110: 529-533. PMID: 8566601, DOI: 10.1053/gast.1996.v110.pm8566601.Peer-Reviewed Original ResearchConceptsEsophageal varicesVariceal eradicationCombined therapyTreatment sessionsMajor bleedingMean followEndoscopic sclerotherapyHospital daysRepeat endoscopyRandomized comparisonSclerotherapyVaricesPatientsAbstractTextTherapyMore sessionsLigationEradicationComplicationsSignificant differencesAIMSTreatmentSessionsGreater timeBleeding