2014
Low Adherence to Helicobacter pylori Testing in Hospitalized Patients with Bleeding Peptic Ulcer Disease
Kim JJ, Lee JS, Olafsson S, Laine L. Low Adherence to Helicobacter pylori Testing in Hospitalized Patients with Bleeding Peptic Ulcer Disease. Helicobacter 2014, 19: 98-104. PMID: 24617668, DOI: 10.1111/hel.12114.Peer-Reviewed Original ResearchConceptsH. pylori testingProportion of patientsIndex hospitalizationHospitalized patientsConsecutive hospitalized patientsPeptic ulcer diseaseHelicobacter pylori testingInitial endoscopyUlcer diseaseSerologic testingSingle centerEndoscopy databaseSociety guidelinesGastric ulcerLow adherencePatientsUlcersMultivariate analysisHelicobacter pyloriHospitalizationDirect testingBiopsyTestingEndoscopyPylori
2011
Double-Blind Randomized Trials of Single-Tablet Ibuprofen/High-Dose Famotidine vs. Ibuprofen Alone for Reduction of Gastric and Duodenal Ulcers
Laine L, Kivitz AJ, Bello AE, Grahn AY, Schiff MH, Taha AS. Double-Blind Randomized Trials of Single-Tablet Ibuprofen/High-Dose Famotidine vs. Ibuprofen Alone for Reduction of Gastric and Duodenal Ulcers. The American Journal Of Gastroenterology 2011, 107: ajg2011443. PMID: 22186979, PMCID: PMC3321505, DOI: 10.1038/ajg.2011.443.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAdultAgedAged, 80 and overAnti-Inflammatory Agents, Non-SteroidalAnti-Ulcer AgentsChi-Square DistributionDouble-Blind MethodDrug CombinationsDuodenal UlcerEndoscopy, GastrointestinalFamotidineFemaleHumansIbuprofenMaleMiddle AgedProportional Hazards ModelsRisk FactorsStomach UlcerTreatment OutcomeConceptsPrimary end point analysisNon-steroidal anti-inflammatory drugsUpper GI ulcersDuodenal ulcerGI ulcersGastric ulcerEnd-point analysisDaily non-steroidal anti-inflammatory drugsH. pylori stool testDouble-blind randomized trialsMultiple potential risk factorsReduction of gastricSingle-tablet combinationUpper gastrointestinal ulcersDouble-blind trialProportional hazards analysisPotential risk factorsAnti-inflammatory drugsBaseline endoscopyREDUCE studyStudy endoscopyTablets thriceUlcer complicationsStool testRandomized trials
1996
Nonsteroidal Anti-Inflammatory Drug Gastropathy
Laine L. Nonsteroidal Anti-Inflammatory Drug Gastropathy. Gastrointestinal Endoscopy Clinics Of North America 1996, 6: 489-504. PMID: 8803564, DOI: 10.1016/s1052-5157(18)30351-9.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGastrointestinal complicationsSubepithelial hemorrhageNonsteroidal anti-inflammatory drug gastropathyDevelopment of NSAIDUpper abdominal symptomsGastric outlet obstructionHalf of patientsPost-treatment biopsiesH. pylori infectionReactive gastritisAbdominal symptomsMajor bleedingMinor bleedingNSAID useUlcer complicationsGastrointestinal bleedingNSAID ingestionNSAID gastropathyOutlet obstructionDuodenal ulcerGastric erosionsHistologic gastritisGastric lesionsGastric ulcerPeptic ulcer
1995
A randomized, double-blind comparison of placebo, etodolac, and naproxen on gastrointestinal injury and prostaglandin production
Laine L, Sloane R, Ferretti M, Cominelli F. A randomized, double-blind comparison of placebo, etodolac, and naproxen on gastrointestinal injury and prostaglandin production. Gastrointestinal Endoscopy 1995, 42: 428-433. PMID: 8566633, DOI: 10.1016/s0016-5107(95)70045-5.Peer-Reviewed Original ResearchConceptsProstaglandin productionWeek 1Gastrointestinal injuryGastric injuryHealthy volunteersDimension of ulcersMucosal prostaglandin productionDouble-blind trialDouble-blind comparisonWeeks of treatmentMean numberProstaglandin E2 productionAnti-ulcer drugsGastroduodenal injuryGastrointestinal symptomsUlcer complicationsPrior endoscopyStandard NSAIDsGastric erosionsGastric ulcerMucosal defectsUlcer scoreWeek 4E2 productionPlacebo
1993
HELICOBACTER PYLORI, GASTRIC ULCER, AND AGENTS NOXIOUS TO THE GASTRIC MUCOSA
Laine L. HELICOBACTER PYLORI, GASTRIC ULCER, AND AGENTS NOXIOUS TO THE GASTRIC MUCOSA. Gastroenterology Clinics Of North America 1993, 22: 117-125. PMID: 8449561, DOI: 10.1016/s0889-8553(21)00267-3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsH. pylori prevalenceGastric ulcerHistologic gastritisH. pyloriGastric injuryPylori prevalenceDuodenal ulcerGastric mucosaNoxious agentsInflammatory cell infiltrateH. pylori infectionNSAID usersCell infiltratePylori infectionDuodenal contentsNSAIDsUlcersGross injuryGastritisPatientsHelicobacter pyloriPyloriInjuryMucosaPrevalence