1998
Has the impact of helicobacter pylori therapy on ulcer recurrence in the united states been overstated?
Laine L, Hopkins R, Girardi L. Has the impact of helicobacter pylori therapy on ulcer recurrence in the united states been overstated? The American Journal Of Gastroenterology 1998, 93: 1409. PMID: 9732917, DOI: 10.1111/j.1572-0241.1998.452_a.x.Peer-Reviewed Original ResearchConceptsH. pylori eradicationH. pylori therapyUlcer recurrencePylori eradicationPylori therapyH. pylori cureNon-NSAID ulcersCompletion of therapyHelicobacter pylori therapyUse of NSAIDsDuodenal ulcer patientsNorth American trialsUlcer recurrence rateHigh methodological qualityEndoscopic biopsy testsReview of abstractsEndoscopic followUlcer patientsDuodenal ulcerRelevant trialsRecurrence rateStudy inclusionOdds ratioCommon odds ratioMethodological quality
1991
Nosocomial Pneumonia and the Role of Gastric pH A Meta-Analysis
Cook D, Laine L, Guyatt G, Raffin T. Nosocomial Pneumonia and the Role of Gastric pH A Meta-Analysis. CHEST Journal 1991, 100: 7-13. PMID: 1676361, DOI: 10.1378/chest.100.1.7.Peer-Reviewed Original ResearchConceptsStress ulcer prophylaxisUse of sucralfateIncidence of pneumoniaUlcer prophylaxisNosocomial pneumoniaIll patientsGastric pHHistamine-2 receptor antagonistsLarger prospective randomized trialsPercent risk reductionTrial of prophylaxisProspective randomized trialsComputerized bibliographic searchDuplicate independent reviewEffect of antacidIndependent reviewProphylactic therapyRandomized trialsDecreased incidenceControl therapyOdds ratioCommon odds ratioLower incidenceMethodologic deficienciesPneumonia