2020
Long-term Outcomes Following Multiply Recurrent Clostridioides difficile Infection and Fecal Microbiota Transplantation
Dawwas GK, Brensinger CM, Vajravelu RK, Wu Q, Kelly CR, Laine L, Wu GD, Lewis JD. Long-term Outcomes Following Multiply Recurrent Clostridioides difficile Infection and Fecal Microbiota Transplantation. Clinical Gastroenterology And Hepatology 2020, 20: 806-816.e6. PMID: 33307184, PMCID: PMC8184854, DOI: 10.1016/j.cgh.2020.12.004.Peer-Reviewed Original ResearchConceptsFecal microbiota transplantationIrritable bowel syndromeImmune-mediated diseasesBowel syndromeMyocardial infarctionMicrobiota transplantationRecurrent Clostridioides difficile infectionRecurrent Clostridioides difficileRetrospective cohort studyImmune-mediated conditionsInflammatory bowel diseaseInflammatory bowel syndromeCommercial claims databaseLong-term outcomesClostridioides difficile infectionCohort studyBowel diseaseMicrobiota disturbanceRheumatoid arthritisClaims databaseDifficile infectionHigh riskHigh incidenceGut microbiotaSignificant associationFecal Microbiota Transplantation Is Highly Effective in Real-World Practice: Initial Results From the FMT National Registry
Kelly CR, Yen EF, Grinspan AM, Kahn SA, Atreja A, Lewis JD, Moore TA, Rubin DT, Kim AM, Serra S, Nersesova Y, Fredell L, Hunsicker D, McDonald D, Knight R, Allegretti JR, Pekow J, Absah I, Hsu R, Vincent J, Khanna S, Tangen L, Crawford CV, Mattar MC, Chen LA, Fischer M, Arsenescu RI, Feuerstadt P, Goldstein J, Kerman D, Ehrlich AC, Wu GD, Laine L. Fecal Microbiota Transplantation Is Highly Effective in Real-World Practice: Initial Results From the FMT National Registry. Gastroenterology 2020, 160: 183-192.e3. PMID: 33011173, PMCID: PMC8034505, DOI: 10.1053/j.gastro.2020.09.038.Peer-Reviewed Original ResearchConceptsClostridioides difficile infectionMicrobiota transplantationSafety profileNational registryProspective real-world studyFull safety profileProspective safety dataBaseline patient characteristicsInflammatory bowel diseaseIrritable bowel syndromeFecal microbiota transplantationLong-term safety outcomesGood safety profileReal-world studyAbdominal painBowel syndromePatient characteristicsReal-world practiceBowel diseaseCDI recurrenceDifficile infectionSafety dataSafety outcomesEffectiveness outcomesSevere symptoms
2017
Optimizing the quality of endoscopy in inflammatory bowel disease: focus on surveillance and management of colorectal dysplasia using interactive image- and video-based teaching
Kaltenbach TR, Soetikno RM, DeVivo R, Laine LA, Barkun A, McQuaid KR, Group O, Cheifetz A, Chiorean M, East J, Farraye F, Leighton J, Levesque B, Lichtenstein G, Marion J, Matsumoto T, Mönkemüller K, Picco M, Odze R, Raju G, Rutter M, Rex D, Shen B, Shergill A, Subramanian V. Optimizing the quality of endoscopy in inflammatory bowel disease: focus on surveillance and management of colorectal dysplasia using interactive image- and video-based teaching. Gastrointestinal Endoscopy 2017, 86: 1107-1117.e1. PMID: 28818507, DOI: 10.1016/j.gie.2017.07.045.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseManagement of dysplasiaUse of chromoendoscopyVisible dysplastic lesionsIBD surveillanceQuiescent diseaseBowel diseaseDysplastic lesionsDysplasia detectionColonic inflammatory bowel diseaseColorectal Endoscopic Neoplasia DetectionInflammatory bowel disease patientsBowel disease patientsUptake of strategiesQuality of endoscopyInternational consensus recommendationsEvidence-based advancesAcademic medical centerDetection of dysplasiaImage-enhanced endoscopyUse of EMRDysplasia managementIBD courseColorectal dysplasiaDisease activity
2016
Paradigm Shift in the Surveillance and Management of Dysplasia in Inflammatory Bowel Disease (West)
Soetikno R, Kaltenbach T, McQuaid KR, Subramanian V, Kumar R, Barkun AN, Laine L. Paradigm Shift in the Surveillance and Management of Dysplasia in Inflammatory Bowel Disease (West). Digestive Endoscopy 2016, 28: 266-273. PMID: 26866420, DOI: 10.1111/den.12634.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsManagement of dysplasiaColorectal cancerUlcerative colitisInflammatory bowel disease colitisCrohn's disease (CD) colitisInflammatory bowel diseaseEarly colorectal cancerDysplasia associated lesionHigh-definition colonoscopyInstitute of MedicineNew surveillance paradigmMost dysplasiaColorectal dysplasiaResectable lesionsSurveillance colonoscopyBowel diseaseGRADE methodologyAssociated lesionsTargeted biopsiesConsensus statementHigh riskGeneral populationEndoscopic recognitionGuideline developmentDysplasia
2015
Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook
Kelly CR, Kahn S, Kashyap P, Laine L, Rubin D, Atreja A, Moore T, Wu G. Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook. Gastroenterology 2015, 149: 223-237. PMID: 25982290, PMCID: PMC4755303, DOI: 10.1053/j.gastro.2015.05.008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsFecal microbiota transplantationClostridium difficile infectionGut microbiotaRecurrent Clostridium difficile infectionInflammatory bowel diseaseIrritable bowel syndromeTreatment of patientsRobust safety dataLong-term safetyBowel diseaseBowel syndromeMetabolic syndromeMicrobiota transplantationDifficile infectionSafety dataTherapeutic efficacyOrgan systemsDisease statesHuman gutSyndromePossible roleDiseaseEfficacyMicrobiotaTreatmentSCENIC International Consensus Statement on Surveillance and Management of Dysplasia in Inflammatory Bowel Disease
Laine L, Kaltenbach T, Barkun A, McQuaid KR, Subramanian V, Soetikno R, Panel S, East J, Farraye F, Feagan B, Ioannidis J, Kiesslich R, Krier M, Matsumoto T, McCabe R, Mönkemüller K, Odze R, Picco M, Rubin D, Rubin M, Rubio C, Rutter M, Sanchez-Yague A, Sanduleanu S, Shergill A, Ullman T, Velayos F, Yakich D, Yang Y. SCENIC International Consensus Statement on Surveillance and Management of Dysplasia in Inflammatory Bowel Disease. Gastroenterology 2015, 148: 639-651.e28. PMID: 25702852, DOI: 10.1053/j.gastro.2015.01.031.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSCENIC international consensus statement on surveillance and management of dysplasia in inflammatory bowel disease
Laine L, Kaltenbach T, Barkun A, McQuaid KR, Subramanian V, Soetikno R, Panel S, East J, Farraye F, Feagan B, Ioannidis J, Kiesslich R, Krier M, Matsumoto T, McCabe R, Mönkemüller K, Odze R, Picco M, Rubin D, Rubin M, Rubio C, Rutter M, Sanchez-Yague A, Sanduleanu S, Shergill A, Ullman T, Velayos F, Yakich D, Yang Y. SCENIC international consensus statement on surveillance and management of dysplasia in inflammatory bowel disease. Gastrointestinal Endoscopy 2015, 81: 489-501.e26. PMID: 25708752, DOI: 10.1016/j.gie.2014.12.009.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2010
Cytomegalovirus Infection in Patients with Active Inflammatory Bowel Disease
Kim JJ, Simpson N, Klipfel N, DeBose R, Barr N, Laine L. Cytomegalovirus Infection in Patients with Active Inflammatory Bowel Disease. Digestive Diseases And Sciences 2010, 55: 1059-1065. PMID: 20112061, DOI: 10.1007/s10620-010-1126-4.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseActive inflammatory bowel diseaseActive ulcerative colitisUC patientsIndex flareCMV infectionUlcerative colitisCrohn's diseaseCytomegalovirus infectionBowel diseasePrevalence of CMVCourse of diseaseAcute exacerbationIBD colitisUC flareCMV antigensConclusionsThe prevalenceIndex endoscopyMethodsConsecutive patientsClinical courseSevere morbidityClinical featuresImmunohistochemistry stainingGeneral populationPatients