2023
Trends in Upper Gastrointestinal Bleeding in Patients on Primary Prevention Aspirin: A Nationwide Emergency Department Sample Analysis, 2016-2020
Li D, Laine L, Shung D. Trends in Upper Gastrointestinal Bleeding in Patients on Primary Prevention Aspirin: A Nationwide Emergency Department Sample Analysis, 2016-2020. The American Journal Of Medicine 2023, 136: 1179-1186.e1. PMID: 37696350, PMCID: PMC10841721, DOI: 10.1016/j.amjmed.2023.08.010.Peer-Reviewed Original ResearchConceptsUpper gastrointestinal bleedingGastrointestinal bleedingRed blood cell transfusionNationwide Emergency Department SamplePrimary cardiovascular preventionRecent guideline recommendationsBlood cell transfusionProportion of hospitalizationsEmergency Department SampleMedicare reimbursementInternational Statistical ClassificationRelated Health ProblemsCardiovascular preventionCell transfusionOlder patientsHospital admissionCommon etiologyGuideline recommendationsMajor complicationsUlcer diseaseEndoscopic interventionRevision codesAppropriate indicationsRecent guidelinesCardiovascular disease
2009
Proton Pump Inhibitors and Bone Fractures?
Laine L. Proton Pump Inhibitors and Bone Fractures? The American Journal Of Gastroenterology 2009, 104: ajg200948. PMID: 19262543, DOI: 10.1038/ajg.2009.48.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsProton pump inhibitorsAverage daily dosePPI useHip fractureDaily dosePump inhibitorsReceptor antagonistContinuous proton-pump inhibitorsCase-control studyPotential confounding factorsDose-response relationshipLack of associationManitoba patientsAppropriate indicationsUK patientsCalcium absorptionFracture riskMEDLINE searchBone fracturesHigh dosesConfounding factorsCausal associationDuration responseRelevant articlesLonger duration