2000
Hepatocyte growth factor induces MAPK-dependent formin IV translocation in renal epithelial cells.
O'Rourke DA, Liu ZX, Sellin L, Spokes K, Zeller R, Cantley L. Hepatocyte growth factor induces MAPK-dependent formin IV translocation in renal epithelial cells. Journal Of The American Society Of Nephrology 2000, 11: 2212-2221. PMID: 11095644, DOI: 10.1681/asn.v11122212.Peer-Reviewed Original ResearchConceptsFormin isoformsHepatocyte growth factorRenal epithelial cellsEpithelial tubule formationProtein kinase-dependent mannerUreteric bud outgrowthExtracellular signal-regulated kinaseQuiescent epithelial cellsEpithelial cellsFamily of proteinsProtein kinase inhibitor U0126Mitogen-activated protein kinase-dependent mannerKinase-dependent mannerMitogen-activated protein kinase inhibitor U0126Kinase inhibitor U0126Cell-matrix interactionsCell-cell interactionsGrowth factorSignal-regulated kinaseTubule formationSoluble cell lysateRapid relocalizationPhosphorylation substratesActin cytoskeletonCellular relocalization
1996
An 11-Amino Acid Sequence from c-met Initiates Epithelial Chemotaxis via Phosphatidylinositol 3-Kinase and Phospholipase C (∗)
Derman M, Chen J, Spokes K, Songyang Z, Cantley L. An 11-Amino Acid Sequence from c-met Initiates Epithelial Chemotaxis via Phosphatidylinositol 3-Kinase and Phospholipase C (∗). Journal Of Biological Chemistry 1996, 271: 4251-4255. PMID: 8626770, DOI: 10.1074/jbc.271.8.4251.Peer-Reviewed Original Research3T3 CellsAmino Acid SequenceAnimalsCell LineChemotaxisCloning, MolecularEpitheliumHepatocyte Growth FactorKidney TubulesMiceMolecular Sequence DataPeptide FragmentsPhosphatidylinositol 3-KinasesPhosphotransferases (Alcohol Group Acceptor)Platelet-Derived Growth FactorPoint MutationProto-Oncogene ProteinsProto-Oncogene Proteins c-metReceptor Protein-Tyrosine KinasesReceptors, Platelet-Derived Growth FactorRecombinant ProteinsTransfectionType C Phospholipases