Differential MAPK Pathways Utilized for HGF- and EGF-dependent Renal Epithelial Morphogenesis*
Karihaloo A, O'Rourke D, Nickel C, Spokes K, Cantley L. Differential MAPK Pathways Utilized for HGF- and EGF-dependent Renal Epithelial Morphogenesis*. Journal Of Biological Chemistry 2000, 276: 9166-9173. PMID: 11118451, DOI: 10.1074/jbc.m009963200.Peer-Reviewed Original ResearchConceptsHepatocyte growth factorP42/44 mitogen-activated protein kinase (MAPK) pathwayEGF-induced cell motilityProtein kinase kinase inhibitor PD98059Mitogen-activated protein kinase kinase inhibitor PD98059Mitogen-activated protein kinase pathwayEGF-dependent migrationProcess formationEGF-stimulated cellsRenal epithelial morphogenesisIndependent signaling pathwaysKinase inhibitor PD98059ERK1/ERK2Protein kinase pathwayEpidermal growth factor receptor ligandsCultured renal epithelial cellsLigand hepatocyte growth factorGrowth factor receptor ligandsCell morphogenesisEpithelial morphogenesisRenal epithelial cellsMKK1 inhibitorCell motilityKinase pathwayInhibitor PD98059