2020
A predictive CD8+ T cell phenotype for T1DM progression
Wong FS, Wen L. A predictive CD8+ T cell phenotype for T1DM progression. Nature Reviews Endocrinology 2020, 16: 198-199. PMID: 32051538, PMCID: PMC8258660, DOI: 10.1038/s41574-020-0330-3.Peer-Reviewed Original Research
2013
Immunotherapy for T1DM—targeting innate immunity
Wong F, Wen L. Immunotherapy for T1DM—targeting innate immunity. Nature Reviews Endocrinology 2013, 9: 384-385. PMID: 23732280, PMCID: PMC4048745, DOI: 10.1038/nrendo.2013.103.Peer-Reviewed Original Research
2005
B cells in autoimmune diabetes.
Wong FS, Wen L. B cells in autoimmune diabetes. The Review Of Diabetic Studies 2005, 2: 121-35. PMID: 17491687, PMCID: PMC1783559, DOI: 10.1900/rds.2005.2.121.Peer-Reviewed Original ResearchAutoimmune diabetesB cellsNon-obese diabetic (NOD) mouse modelAutoantigen-specific B cellsType 1 diabetes mellitusAntigen-presenting functionDiabetic mouse modelAutoreactive B cellsB cell toleranceSpecific B cellsHuman T1DMDiabetes mellitusMouse modelCell toleranceAutoantibodiesGood markerDiabetesPathogenesisDiseaseCellsAspects of deficienciesCritical roleMellitusT1DM
2004
What can the HLA transgenic mouse tell us about autoimmune diabetes?
Wong F, Wen L. What can the HLA transgenic mouse tell us about autoimmune diabetes? Diabetologia 2004, 47: 1476-1487. PMID: 15349728, DOI: 10.1007/s00125-004-1505-5.Peer-Reviewed Original ResearchConceptsHLA transgenic miceType 1 diabetes mellitusTransgenic miceDiabetes mellitusHLA class II allelesCD4 T lymphocytesAntigen-presenting moleculesClass II allelesPeptide-MHC complexesStudies of micePutative autoantigenParticular HLAT lymphocytesHLA moleculesPeptide antigensMHC complexesMiceDiseasePolygenic diseaseMellitusVivo roleInsultIntracellular processingImmunotherapyDiabetes