2019
Folate-Decorated Polyamidoamine Dendrimer Nanoparticles for Head and Neck Cancer Gene Therapy
Xu L, Yang H. Folate-Decorated Polyamidoamine Dendrimer Nanoparticles for Head and Neck Cancer Gene Therapy. Methods In Molecular Biology 2019, 1974: 393-408. PMID: 31099016, DOI: 10.1007/978-1-4939-9220-1_26.BooksConceptsGene therapyGene delivery systemsNeck cancer gene therapyCancer gene therapyDelivery systemNanoparticle carriersGene deliveryDendrimer nanoparticlesHigh biocompatibilityGene transfectionKnockdown efficiencyTumor targetingSuitable platformFolic acidIRDye 800CWSustained retentionGeneration 4DendrimersNanoparticlesBioimagingCarriersBiocompatibilityHereinPlatformPlasmid
2017
Folic acid-decorated polyamidoamine dendrimer exhibits high tumor uptake and sustained highly localized retention in solid tumors: Its utility for local siRNA delivery
Xu L, Yeudall WA, Yang H. Folic acid-decorated polyamidoamine dendrimer exhibits high tumor uptake and sustained highly localized retention in solid tumors: Its utility for local siRNA delivery. Acta Biomaterialia 2017, 57: 251-261. PMID: 28438704, PMCID: PMC5555737, DOI: 10.1016/j.actbio.2017.04.023.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarcinoma, Squamous CellCell Line, TumorDendrimersFemaleFolic AcidGene Transfer TechniquesHead and Neck NeoplasmsHumansMiceMice, NudeNeoplasm ProteinsNeovascularization, PathologicPolyaminesRNA, Small InterferingVascular Endothelial Growth Factor AXenograft Model Antitumor AssaysConceptsHigh tumor uptakeNeck squamous cell carcinomaSquamous cell carcinomaTumor uptakeCell carcinomaLocal deliveryRegimen studiesNeck squamous cancer cellsPronounced tumor suppressionTumor size reductionVascular endothelial growth factorSquamous cancer cellsTumor mouse modelEndothelial growth factorXenograft tumor modelEnhanced tumor uptakeTumor suppressionTumor inhibition effectCommon cancerMicrovessel countImaging assessmentTherapeutic modalitiesMouse modelCD31 stainingTreatment groups
2016
Folic acid-decorated polyamidoamine dendrimer mediates selective uptake and high expression of genes in head and neck cancer cells
Xu L, Kittrell S, Yeudall WA, Yang H. Folic acid-decorated polyamidoamine dendrimer mediates selective uptake and high expression of genes in head and neck cancer cells. Nanomedicine 2016, 11: 2959-2973. PMID: 27781559, PMCID: PMC5144492, DOI: 10.2217/nnm-2016-0244.Peer-Reviewed Original ResearchConceptsNeck cancer cellsCancer cellsFR-dependent mannerEnhanced gene expressionGene expressionSame binding siteCellular uptakeGenesDelivery of genesBinding sitesHigh expressionFree FASuitable vectorPlasmidDNA plasmidsCellsTransfection resultsExpressionTransfection efficiencySelective uptakeUptakeFolate receptorHigh levelsVectorFA
2014
Cholesterol Sulfate and Cholesterol Sulfotransferase Inhibit Gluconeogenesis by Targeting Hepatocyte Nuclear Factor 4α
Shi X, Cheng Q, Xu L, Yan J, Jiang M, He J, Xu M, Stefanovic-Racic M, Sipula I, O'Doherty RM, Ren S, Xie W. Cholesterol Sulfate and Cholesterol Sulfotransferase Inhibit Gluconeogenesis by Targeting Hepatocyte Nuclear Factor 4α. Molecular And Cellular Biology 2014, 34: 485-497. PMID: 24277929, PMCID: PMC3911511, DOI: 10.1128/mcb.01094-13.Peer-Reviewed Original ResearchMeSH KeywordsAcetylationAnimalsBlotting, WesternCarcinoma, HepatocellularCell Line, TumorCell NucleusCells, CulturedCholesterol EstersCoenzyme A LigasesColforsinDiet, High-FatGene ExpressionGluconeogenesisGlucoseHepatocyte Nuclear Factor 4HumansInsulin ResistanceMiceMice, Inbred C57BLMice, ObeseMice, TransgenicObesityReverse Transcriptase Polymerase Chain ReactionSulfotransferasesConceptsDiet-induced obesityHepatocyte nuclear factor 4αNuclear factor 4αCholesterol sulfateLeptin-deficient miceTreatment of micePotential therapeutic targetPotential therapeutic agentExpression of SULT2B1bMetabolic abnormalitiesObese miceMetabolic disordersImportant metabolic regulatorGlucose metabolismTherapeutic targetTransgenic miceFed stateHepatic gluconeogenesisTherapeutic agentsMiceTransgenic overexpressionSULT2B1bMetabolic regulatorFunctional homeostasisInhibits gluconeogenesis