2023
Clinical utility of colonic low‐amplitude propagating contractions in children with functional constipation
Colliard K, Patel D, Nurko S, Rodriguez L. Clinical utility of colonic low‐amplitude propagating contractions in children with functional constipation. Neurogastroenterology & Motility 2023, 35: e14543. PMID: 37096634, DOI: 10.1111/nmo.14543.Peer-Reviewed Original ResearchConceptsFunctional constipationLogistic regressionClinical utilityPediatric functional constipationConstipation groupRetrospective reviewColonic enemaClinical significanceLAPCConstipationNeuromuscular integrityLarger studyPatientsOutcomesChildrenAssociationContractionHigher proportionHAPCsGroupRegressionIleostomyEnema
2022
Diverting Ileostomy in Children With Functional Constipation
Rodriguez L, Colliard K, Nurko S, Flores A, Buchmiller TL. Diverting Ileostomy in Children With Functional Constipation. Journal Of Pediatric Gastroenterology And Nutrition 2022, 75: 578-583. PMID: 35897140, DOI: 10.1097/mpg.0000000000003579.Peer-Reviewed Original ResearchConceptsFunctional constipationOstomy closurePediatric functional constipationInstitutional review board approvalReview board approvalEnema failureColon motilityFurther surgeryInvasive evaluationRetrospective studySurgical interventionOstomyBoard approvalUseful interventionLarger studyConstipationSuccessful responsePatientsSurgeryChildrenRole of CMDemographicsAssociationInterventionIndications
2021
Lower Gastrointestinal Functional and Motility Disorders in Children
Arbizu R, Freiberg B, Rodriguez L. Lower Gastrointestinal Functional and Motility Disorders in Children. Pediatric Clinics Of North America 2021, 68: 1255-1271. PMID: 34736588, DOI: 10.1016/j.pcl.2021.07.010.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnorectal MalformationsBiopsyChildChild, PreschoolColonic DiseasesConstipationErythromycinFemaleGastrointestinal DiseasesGastrointestinal MotilityHirschsprung DiseaseHumansInfantIntestinal Pseudo-ObstructionIntestine, SmallLower Gastrointestinal TractMaleManometryNutritional StatusQuality of LifeConceptsMotility disordersSignificant morbidityTherapeutic interventionsColorectal disordersPediatric gastroenterologistsClinical presentationSmall bowelGastrointestinal disordersCommon complaintDiagnostic evaluationSmall intestineDisordersMorbidityComplicationsSuch interventionsInterventionSocial stigmaPoor qualityBowelAnorectumGastroenterologistsColonMortalityComplaintsIntestineCan Propofol Be Used to Assess the Presence of the Rectoanal Inhibitory Reflex During Anorectal Manometry Studies?
Arbizu RA, Amicangelo M, Rodriguez L, Nurko S. Can Propofol Be Used to Assess the Presence of the Rectoanal Inhibitory Reflex During Anorectal Manometry Studies? Journal Of Pediatric Gastroenterology And Nutrition 2021, 74: 33-37. PMID: 34478251, DOI: 10.1097/mpg.0000000000003283.Peer-Reviewed Original ResearchMeSH KeywordsAnal CanalChildConstipationFemaleHumansMaleManometryPropofolProspective StudiesRectumReflexConceptsIntra-anal pressuresRectoanal inhibitory reflexAnorectal manometryInhibitory reflexAbsent rectoanal inhibitory reflexInternal anal sphincter relaxationNormal rectoanal inhibitory reflexAnal sphincter relaxationAnorectal manometry studyBalloon distentionIAS relaxationSpinal neuropathyIntractable constipationObstructive symptomsSphincter relaxationProspective studyAnesthesia inductionManometry studiesPatientsPropofolDisease repairLatency timeConstipationAnesthesiaReflexMelanosis Coli Is Not Associated with Colonic Dysmotility Nor Severity of Pediatric Functional Constipation
Chen JJ, Kitzia Colliard RN, Nurko S, Rodriguez L. Melanosis Coli Is Not Associated with Colonic Dysmotility Nor Severity of Pediatric Functional Constipation. Digestive Diseases And Sciences 2021, 67: 3922-3928. PMID: 34379221, DOI: 10.1007/s10620-021-07191-z.Peer-Reviewed Original ResearchConceptsPediatric functional constipationMelanosis coliFunctional constipationColonic manometryColonic motilityMarker of severityTreatment of constipationRate of surgeryColonic dysmotilityColonic biopsiesMedian agePediatric patientsManometry resultsMedication historyMethodsProspective studyPatient groupResultsA totalSurgical historyPathologic resultsConstipationPatientsCatheter positionDemographic dataSubsequent needSignificant differences
2020
Evaluation of Fecal Incontinence in Pediatric Functional Constipation
Morera C, Nurko S, Rodriguez L. Evaluation of Fecal Incontinence in Pediatric Functional Constipation. Journal Of Pediatric Gastroenterology And Nutrition 2020, 72: 361-365. PMID: 33560756, DOI: 10.1097/mpg.0000000000002978.Peer-Reviewed Original ResearchConceptsPediatric functional constipationFecal incontinenceFunctional constipationColonic manometryMedian anal resting pressureAnal resting pressureMore patientsResting pressureAbnormal studiesConventional therapyMale genderTreatment outcomesClinical dataConstipationNormal studiesTherapy responseMeal responseIncontinencePatientsMultivariate analysisMotility studiesTherapyNormal armLow responseManometryLong‐term Use of Bisacodyl in Pediatric Functional Constipation Refractory to Conventional Therapy
Bonilla S, Nurko S, Rodriguez L. Long‐term Use of Bisacodyl in Pediatric Functional Constipation Refractory to Conventional Therapy. Journal Of Pediatric Gastroenterology And Nutrition 2020, 71: 288-291. PMID: 32459741, DOI: 10.1097/mpg.0000000000002795.Peer-Reviewed Original ResearchMeSH KeywordsAdultBisacodylChildConstipationFemaleGastrointestinal AgentsHumansLaxativesMaleRetrospective StudiesConceptsConventional therapyLong-term usePediatric constipationFunctional constipationSide effectsTertiary care children's hospitalFrequency of BMPediatric functional constipationBowel movement frequencyLong-term followLong-term treatmentMedian doseRescue therapyMedian durationStandard therapyOsmotic laxativesRetrospective reviewPediatric populationChildren's HospitalStimulant laxativesMedian numberConstipationPatientsTreatment durationFavorable responseUtility of Colon Manometry in Guiding Therapy and Predicting Need for Surgery in Children With Defecation Disorders
Rodriguez L, Heinz N, Nurko S. Utility of Colon Manometry in Guiding Therapy and Predicting Need for Surgery in Children With Defecation Disorders. Journal Of Pediatric Gastroenterology And Nutrition 2020, 70: 232-237. PMID: 31978023, DOI: 10.1097/mpg.0000000000002504.Peer-Reviewed Original ResearchMeSH KeywordsChildColonConstipationDefecationFemaleGastrointestinal MotilityHumansMaleManometryRetrospective StudiesConceptsColon manometryChange of therapyGastrocolonic responseHigh response rateDefecation disordersResponse rateMedical interventionsLogistic regression analysisPresence/numberPediatric constipationFecal incontinenceSuccessful medical interventionDefecation problemsRetrospective reviewPredicting NeedPostsurgical evaluationSurgical interventionStimulant laxativesStudy indicationSurgeryTherapyFirst interventionInterventionConstipationManometry
2018
Primary placement of a skin-level Cecostomy Tube for Antegrade Colonic Enema Administration Using a Modification of the Laparoscopic-Assisted Percutaneous Endoscopic Cecostomy (LAPEC)
Graham CD, Rodriguez L, Flores A, Nurko S, Buchmiller TL. Primary placement of a skin-level Cecostomy Tube for Antegrade Colonic Enema Administration Using a Modification of the Laparoscopic-Assisted Percutaneous Endoscopic Cecostomy (LAPEC). Journal Of Pediatric Surgery 2018, 54: 486-490. PMID: 30409477, DOI: 10.1016/j.jpedsurg.2018.09.013.Peer-Reviewed Original ResearchConceptsSkin-level deviceTube placementPrimary placementCecostomy tubeHigher BMIEnema administrationExact testSingle-institution retrospective reviewSuspension suturesAntegrade enema administrationCecostomy tube placementPercutaneous endoscopic cecostomyPEG tube placementMajority of patientsCase series studyAntegrade colonic enemaPercutaneous needle punctureSuccessful tube placementFisher's exact testBowel managementFecal incontinenceSevere constipationPatient characteristicsPEG placementSite infection
2017
Prospective evaluation of same day versus next day colon manometry results in children with medical refractory constipation
Arbizu RA, Nurko S, Heinz N, Amicangelo M, Rodriguez L. Prospective evaluation of same day versus next day colon manometry results in children with medical refractory constipation. Neurogastroenterology & Motility 2017, 29 PMID: 28317231, PMCID: PMC5466533, DOI: 10.1111/nmo.13050.Peer-Reviewed Original ResearchConceptsDay 1Day 2Normal studiesAbnormal studiesProportion of patientsSame dayStudy interpretationColon manometryGastrocolonic responseRefractory constipationProspective evaluationManometry parametersMotility indexPatientsChallenge phaseAbstractTextAnesthesiaCatheterStudy parametersColonoscopyDaysConstipationHAPCsManometryStudy
2013
Longitudinal and Radial Characteristics of Intra-Anal Pressures in Children Using 3D High-Definition Anorectal Manometry: New Observations
Ambartsumyan L, Rodriguez L, Morera C, Nurko S. Longitudinal and Radial Characteristics of Intra-Anal Pressures in Children Using 3D High-Definition Anorectal Manometry: New Observations. The American Journal Of Gastroenterology 2013, 108: 1918. PMID: 24169274, DOI: 10.1038/ajg.2013.361.Peer-Reviewed Original ResearchRelationship between postprandial metabolomics and colon motility in children with constipation
Rodriguez L, Roberts LD, LaRosa J, Heinz N, Gerszten R, Nurko S, Goldstein AM. Relationship between postprandial metabolomics and colon motility in children with constipation. Neurogastroenterology & Motility 2013, 25: 420-e299. PMID: 23421516, PMCID: PMC3877617, DOI: 10.1111/nmo.12086.Peer-Reviewed Original ResearchConceptsTreatment of constipationColonic motilityMotility indexMotility patternsNormal postprandial increasePostprandial motility patternCohort of childrenPostprandial metabolic changesSignificant metabolite changesColon manometryColon motilityConstipated childrenProspective studyStandardized mealKynurenic acidMeal challengePostprandial increasePostprandial changesMultiple time pointsConstipationLipid metabolitesPotential metabolic targetsAbstractTextSpecific metabolitesMetabolic changes
2012
Factors associated with successful decrease and discontinuation of antegrade continence enemas (ACE) in children with defecation disorders: a study evaluating the effect of ACE on colon motility
Rodriguez L, Nurko S, Flores A. Factors associated with successful decrease and discontinuation of antegrade continence enemas (ACE) in children with defecation disorders: a study evaluating the effect of ACE on colon motility. Neurogastroenterology & Motility 2012, 25: 140-e81. PMID: 23035840, PMCID: PMC3546133, DOI: 10.1111/nmo.12018.Peer-Reviewed Original ResearchMeSH KeywordsChildConstipationEnemaFemaleGastrointestinal MotilityHumansMaleManometryRetrospective StudiesConceptsAntegrade continence enemaColon manometryACE decreaseContinence enemaColon motilityDefecation disordersOlder ageReview of childrenGastrocolonic responseMotility indexOnly predictorMultivariate analysisDiscontinuationAbstractTextEnemaOutcomesPatientsSignificant increaseChildrenSuccessful decreaseDisordersAgeHAPCsMotilityCM changesInternal anal sphincter relaxation associated with bisacodyl‐induced colonic high amplitude propagating contractions in children with constipation: a colo‐anal reflex?
Rodriguez L, Siddiqui A, Nurko S. Internal anal sphincter relaxation associated with bisacodyl‐induced colonic high amplitude propagating contractions in children with constipation: a colo‐anal reflex? Neurogastroenterology & Motility 2012, 24: 1023-e545. PMID: 22757618, PMCID: PMC3465462, DOI: 10.1111/j.1365-2982.2012.01965.x.Peer-Reviewed Original ResearchConceptsHigh-amplitude peristaltic contractionsInternal anal sphincter relaxationAnal sphincter relaxationIAS relaxationSphincter relaxationAnal residual pressureManometry tracingsDefecation disordersConstipated childrenAnal relaxationHepatic flexureResting pressureDistal colonPeristaltic contractionsColonAbstractTextConstipationContraction propagationReflexChildrenImportant proportionContractionMost casesPatientsBisacodyl
2010
Antegrade colonic enemas and intestinal diversion are highly effective in the management of children with intractable constipation
Christison-Lagay ER, Rodriguez L, Kurtz M, St. Pierre K, Doody DP, Goldstein AM. Antegrade colonic enemas and intestinal diversion are highly effective in the management of children with intractable constipation. Journal Of Pediatric Surgery 2010, 45: 213-219. PMID: 20105606, DOI: 10.1016/j.jpedsurg.2009.10.034.Peer-Reviewed Original ResearchConceptsAntegrade continence enemaIntractable constipationSatisfactory outcomeContinence enemaIntestinal continuityRetrospective reviewSurgical approachPredictors of successColonic manometry studiesPassage of stoolPrimary colonic resectionManagement of childrenOptimal surgical approachAntegrade colonic enemaInitial therapyAbdominal distensionIdiopathic constipationPrimary resectionColonic resectionAdditional surgeryColonic manometryMedical therapyPediatric patientsACE procedureColonic enema
2008
Botulinum toxin for the treatment of chronic constipation in children with internal anal sphincter dysfunction
Irani K, Rodriguez L, Doody DP, Goldstein AM. Botulinum toxin for the treatment of chronic constipation in children with internal anal sphincter dysfunction. Pediatric Surgery International 2008, 24: 779-783. PMID: 18443801, DOI: 10.1007/s00383-008-2171-3.Peer-Reviewed Original ResearchConceptsInternal anal sphincter dysfunctionAnal sphincter dysfunctionIntrasphincteric injectionSphincter dysfunctionIntractable constipationPediatric patientsBotulinum toxinIAS dysfunctionAbnormal anorectal manometryRectoanal inhibitory reflexTreatment of constipationDuration of effectChronic constipationPostoperative incontinenceRefractory constipationInhibitory reflexAnorectal manometryResting pressureRetrospective reviewBotox injectionHirschsprung's diseaseConstipationEffective treatmentPatientsDysfunction