Mesenchymal Stromal Cell Therapy Alleviates Ovalbumin-Induced Chronic Airway Remodeling by Suppressing M2 Macrophage Polarization
Yu H, Zhu G, Qin Q, Wang X, Guo X, Gu W. Mesenchymal Stromal Cell Therapy Alleviates Ovalbumin-Induced Chronic Airway Remodeling by Suppressing M2 Macrophage Polarization. Inflammation 2024, 47: 1298-1312. PMID: 38316671, DOI: 10.1007/s10753-024-01977-9.Peer-Reviewed Original ResearchSuppressed macrophage M2 polarizationEffect of mesenchymal stromal/stem cellsMesenchymal stromal/stem cellsChronic airway remodelingAirway remodelingChronic asthmaTherapeutic effects of mesenchymal stromal/stem cellsMacrophage M2 polarizationMouse modelModel of chronic asthmaMouse model of chronic asthmaTh2 cytokine levelsTransforming growth factor-bM2 polarizationMechanisms of airway remodelingInflammatory cell infiltrationInhibition of ER stressSuppressing M2 macrophage polarizationER stressGrowth factor BOxidative stressPhenotype of macrophagesAnti-inflammatory effectsM2 macrophage polarizationAirway hyperresponsiveness