Xueting (Leona) Wang
she/her/hers, they/them/theirs
PhD Student, Computational Biology & BioinformaticsAbout
Research
Publications
2024
Mesenchymal Stromal Cell Therapy Alleviates Ovalbumin-Induced Chronic Airway Remodeling by Suppressing M2 Macrophage Polarization
Yu H, Zhu G, Qin Q, Wang X, Guo X, Gu W. Mesenchymal Stromal Cell Therapy Alleviates Ovalbumin-Induced Chronic Airway Remodeling by Suppressing M2 Macrophage Polarization. Inflammation 2024, 1-15. PMID: 38316671, DOI: 10.1007/s10753-024-01977-9.Peer-Reviewed Original ResearchSuppressed macrophage M2 polarizationEffect of mesenchymal stromal/stem cellsMesenchymal stromal/stem cellsChronic airway remodelingAirway remodelingChronic asthmaTherapeutic effects of mesenchymal stromal/stem cellsMacrophage M2 polarizationMouse modelModel of chronic asthmaMouse model of chronic asthmaTh2 cytokine levelsTransforming growth factor-bM2 polarizationMechanisms of airway remodelingInflammatory cell infiltrationInhibition of ER stressSuppressing M2 macrophage polarizationER stressGrowth factor BOxidative stressPhenotype of macrophagesAnti-inflammatory effectsM2 macrophage polarizationAirway hyperresponsiveness
2023
Subsets of IFN Signaling Predict Response to Immune Checkpoint Blockade in Patients with Melanoma.
Horowitch B, Lee D, Ding M, Martinez-Morilla S, Aung T, Ouerghi F, Wang X, Wei W, Damsky W, Sznol M, Kluger H, Rimm D, Ishizuka J. Subsets of IFN Signaling Predict Response to Immune Checkpoint Blockade in Patients with Melanoma. Clinical Cancer Research 2023, 29: 2908-2918. PMID: 37233452, PMCID: PMC10524955, DOI: 10.1158/1078-0432.ccr-23-0215.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsHuman melanoma cell linesMelanoma cell linesPD-L1Validation cohortYale-New Haven HospitalCombination of ipilimumabPD-L1 markersImmune checkpoint blockadePD-L1 biomarkerNew Haven HospitalSTAT1 levelsCell linesWestern blot analysisCheckpoint inhibitorsCheckpoint blockadeClinical responseOverall survivalImproved survivalResistance of cancersMetastatic melanomaMelanoma responsePredict responseTreatment responseDistinct patterns
2020
p62-dependent autophagy in airway smooth muscle cells regulates metabolic reprogramming and promotes airway remodeling
Yu H, Cheng Y, Zhang G, Wang X, Gu W, Guo X. p62-dependent autophagy in airway smooth muscle cells regulates metabolic reprogramming and promotes airway remodeling. Life Sciences 2020, 266: 118884. PMID: 33310038, DOI: 10.1016/j.lfs.2020.118884.Peer-Reviewed Original ResearchConceptsKnockdown of p62Mechanism of p62Bronchial smooth muscle cellsP62-dependent autophagyIncreased p62 expressionP62 expressionAirway remodelingGlucose consumptionAutophagy fluxAutophagic fluxCCK8 assayP62 overexpressionTranswell methodP62Glycolytic genesGlycolytic proteinsLactate productionMetabolic reprogrammingMigration in vitroHuman bronchial smooth muscle cellsBSMC proliferationCell migrationSmooth muscle cellsAirway remodeling processPromote airway remodelingResearch progress of metabolomics in bronchial asthma
Wang X, Gu W. Research progress of metabolomics in bronchial asthma. International Journal Of Respiration 2020, 40: 847-852. DOI: 10.3760/cma.j.cn131368-20190318-00378.Peer-Reviewed Original ResearchProgress of metabolomicsMethods of metabolomicsVariable expiratory airflow limitationHistory of respiratory symptomsLow molecular weight metabolitesExpiratory airflow limitationHeterogeneity of asthmaAspects of diagnosisChronic respiratory diseasesAirflow limitationMetabolomicsRespiratory symptomsBronchial asthmaPathology in vivoMetabolite fluctuationsAsthmaResearch progressRespiratory diseaseDiseasePhenotypeMetabolitesDiagnosisSymptomsDrugPathology
2019
Detection of pulmonary ground-glass opacity based on deep learning computer artificial intelligence
Ye W, Gu W, Guo X, Yi P, Meng Y, Han F, Yu L, Chen Y, Zhang G, Wang X. Detection of pulmonary ground-glass opacity based on deep learning computer artificial intelligence. BioMedical Engineering OnLine 2019, 18: 6. PMID: 30670024, PMCID: PMC6343356, DOI: 10.1186/s12938-019-0627-4.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsDatabases, FactualDeep LearningDiagnosis, Computer-AssistedFalse Positive ReactionsHumansImage Processing, Computer-AssistedLungLung NeoplasmsRadiographic Image Interpretation, Computer-AssistedRadiologyReproducibility of ResultsSensitivity and SpecificitySolitary Pulmonary NoduleTomography, X-Ray ComputedConceptsDeep learningF-scoreLung Image Database Consortium and Image Database Resource Initiative (LIDC-IDRI) databaseMethod of deep learningArtificial intelligence systemsInput imageNetwork trainingDetect pulmonary nodulesIdentification of lung nodulesIntelligent systemsNodule classificationGround-glass opacity imagesPreprocessing methodsDetect ground-glass opacitiesEvaluation resultsLearningAccuracyAlexNetResNet50PreprocessingImagesThree-dimensional featuresGround-glass opacitiesNetworkFeatures