Featured Publications
Effectiveness of Nirmatrelvir-Ritonavir Against the Development of Post-COVID-19 Conditions Among U.S. Veterans : A Target Trial Emulation.
Ioannou G, Berry K, Rajeevan N, Li Y, Mutalik P, Yan L, Bui D, Cunningham F, Hynes D, Rowneki M, Bohnert A, Boyko E, Iwashyna T, Maciejewski M, Osborne T, Viglianti E, Aslan M, Huang G, Bajema K. Effectiveness of Nirmatrelvir-Ritonavir Against the Development of Post-COVID-19 Conditions Among U.S. Veterans : A Target Trial Emulation. Annals Of Internal Medicine 2023, 176: 1486-1497. PMID: 37903369, PMCID: PMC10620954, DOI: 10.7326/m23-1394.Peer-Reviewed Original ResearchConceptsAcute COVID-19Veterans Health AdministrationUntreated comparatorsThromboembolic eventsCOVID-19Severe COVID-19Target trial emulationSARS-CoV-2Post COVID-19 conditionIndex dateVenous thromboembolismBaseline characteristicsCumulative incidencePulmonary embolismAcute infectionMedian ageOral antiviralsTrial emulationVHA careOutpatient treatmentInternational ClassificationHealth AdministrationU.S. veteransVeterans AffairsOrgan systemsAnti–SARS-CoV-2 Pharmacotherapies Among Nonhospitalized US Veterans, January 2022 to January 2023
Yan L, Streja E, Li Y, Rajeevan N, Rowneki M, Berry K, Hynes D, Cunningham F, Huang G, Aslan M, Ioannou G, Bajema K. Anti–SARS-CoV-2 Pharmacotherapies Among Nonhospitalized US Veterans, January 2022 to January 2023. JAMA Network Open 2023, 6: e2331249. PMID: 37651140, PMCID: PMC10472184, DOI: 10.1001/jamanetworkopen.2023.31249.Peer-Reviewed Original ResearchConceptsCOVID-19 pharmacotherapyVeterans Health AdministrationVeterans Integrated Service NetworkSARS-CoV-2Higher Charlson Comorbidity Index scoresCharlson Comorbidity Index scoreNon-Hispanic veteransComorbidity Index scoreProportion of patientsSymptomatic COVID-19Multivariable logistic regressionCOVID-19 vaccinationCohort studyMedicare databaseVHA careUS veteransMAIN OUTCOMEMedical conditionsHispanic veteransPharmacotherapyHealth AdministrationIndex scoreCommunity careNonhospitalized personsWhite veteransEffectiveness of COVID-19 Treatment With Nirmatrelvir–Ritonavir or Molnupiravir Among U.S. Veterans: Target Trial Emulation Studies With One-Month and Six-Month Outcomes
Bajema K, Berry K, Streja E, Rajeevan N, Li Y, Mutalik P, Yan L, Cunningham F, Hynes D, Rowneki M, Bohnert A, Boyko E, Iwashyna T, Maciejewski M, Osborne T, Viglianti E, Aslan M, Huang G, Ioannou G. Effectiveness of COVID-19 Treatment With Nirmatrelvir–Ritonavir or Molnupiravir Among U.S. Veterans: Target Trial Emulation Studies With One-Month and Six-Month Outcomes. Annals Of Internal Medicine 2023, 176: m22-3565. PMID: 37276589, PMCID: PMC10243488, DOI: 10.7326/m22-3565.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationCOVID-19 symptom onsetCOVID-19-related outcomesSevere COVID-19Six-month outcomesCOVID-19 vaccinationCOVID-19 treatmentCOVID-19SARS-CoV-2Percent of participantsUntreated control participantsCause mortalitySymptom onsetMedian ageOral antiviralsVHA careOutpatient treatmentHospitalizationHealth AdministrationDay 31U.S. veteransVariant transmissionMost veteransVeterans AffairsOne monthEarly Adoption of Anti–SARS-CoV-2 Pharmacotherapies Among US Veterans With Mild to Moderate COVID-19, January and February 2022
Bajema K, Wang X, Hynes D, Rowneki M, Hickok A, Cunningham F, Bohnert A, Boyko E, Iwashyna T, Maciejewski M, Viglianti E, Streja E, Yan L, Aslan M, Huang G, Ioannou G. Early Adoption of Anti–SARS-CoV-2 Pharmacotherapies Among US Veterans With Mild to Moderate COVID-19, January and February 2022. JAMA Network Open 2022, 5: e2241434. PMID: 36367727, PMCID: PMC9652752, DOI: 10.1001/jamanetworkopen.2022.41434.Peer-Reviewed Original ResearchConceptsCOVID-19 pharmacotherapySevere COVID-19SARS-CoV-2Health care systemCohort studyRisk factorsCare systemMedical conditionsCOVID-19Positive SARS-CoV-2 testVeterans Affairs Health Care SystemCOVID-19-related hospitalizationCOVID-19-related symptomsLarge integrated health care systemSARS-CoV-2 testVA health care systemIntegrated health care systemNon-Hispanic veteransModerate COVID-19Odds of receiptMultivariable logistic regressionCOVID-19 vaccinationMedical comorbiditiesMedian ageAnti-SARS
2024
Embryo Cryopreservation Strategy May Improve Live Birth for Women Underwent In Vitro Maturation After Early Oocyte Retrieval: A Retrospective Cohort Study
Luo C, Zhang J, Wang X, Dai Y, Yan L, Du Y. Embryo Cryopreservation Strategy May Improve Live Birth for Women Underwent In Vitro Maturation After Early Oocyte Retrieval: A Retrospective Cohort Study. Reproductive Sciences 2024, 1-10. PMID: 39630368, DOI: 10.1007/s43032-024-01756-9.Peer-Reviewed Original ResearchIn vitro maturationIn vitro maturation cyclesLive birth rateOocyte retrievalRetrospective cohort studyLive birthsFresh cyclesCohort studyFrozen-thawed embryo transfer cyclesEarly pregnancy loss rateEmbryo transfer cyclesOocyte retrieval cycleFrozen-thawed embryosPregnancy loss rateReproductive Medical CenterEarly pregnancy lossOptimal transplantation strategyMaturation of oocytesEmbryo transfer strategyBirth rateSperm injectionPregnancy outcomesPregnancy lossRetrieval cycleTransfer cyclesCorrigendum: Pretreatment level of serum sialic acid predicts both qualitative and quantitative bone metastases of prostate cancer
Sun J, Tian T, Wang N, Jing X, Qiu L, Cui H, Liu Z, Liu J, Yan L, Li D. Corrigendum: Pretreatment level of serum sialic acid predicts both qualitative and quantitative bone metastases of prostate cancer. Frontiers In Endocrinology 2024, 15: 1466189. PMID: 39253582, PMCID: PMC11381961, DOI: 10.3389/fendo.2024.1466189.Peer-Reviewed Original ResearchHighly expressed lncRNA H19 in endometriosis promotes aerobic glycolysis and histone lactylation
Wen X, Zhang J, Xu Z, Li M, Dong X, Du Y, Xu Z, Yan L. Highly expressed lncRNA H19 in endometriosis promotes aerobic glycolysis and histone lactylation. Reproduction 2024, 168: e240018. PMID: 38744310, PMCID: PMC11301422, DOI: 10.1530/rep-24-0018.Peer-Reviewed Original ResearchConceptsAbnormal glucose metabolismIncreased aerobic glycolysisAerobic glycolysisHistone lactylationGlucose metabolismHistone lactylation levelsEndometriosis tissueH19 expressionEctopic endometriosis tissueHuman endometrial stromal cellsEndometriosis mouse modelCell proliferationPathogenesis of endometriosisProtein levels of enzymesProgression of endometriosisLevels of aerobic glycolysisEndometrial stromal cellsAssociation of lower urinary tract symptoms and geriatric nutritional risk index in men: a cross-sectional study based on NHANES
Zheng T, Sun H, Tang Y, Zeng Y, Yan L. Association of lower urinary tract symptoms and geriatric nutritional risk index in men: a cross-sectional study based on NHANES. Frontiers In Medicine 2024, 11: 1356921. PMID: 38975054, PMCID: PMC11224433, DOI: 10.3389/fmed.2024.1356921.Peer-Reviewed Original ResearchGeriatric Nutritional Risk IndexAssociated with GNRINutritional risk indexNutritional statusLow Geriatric Nutritional Risk IndexImpact of nutritional statusDevelopment of LUTSUrinary tract symptomsTreatment of LUTSMultivariate logistic analysisUnadjusted regression modelsCross-sectional studyImproving LUTSCross-sectional analysisNocturiaLogistic analysisEligible participantsOlder menMiddle-agedRelevant questionnairesRegression modelsRisk indexNHANESSymptomsMenAssociation Between Pregnancy Outcomes and the Time of Progesterone Exposure of D6 Single-Blastocyst Transfer in Frozen-Thawed Cycles: A Retrospective Cohort Study
Qi D, Zhang X, Li F, Zhao S, Wang Q, Liu W, Yan L, Du Y. Association Between Pregnancy Outcomes and the Time of Progesterone Exposure of D6 Single-Blastocyst Transfer in Frozen-Thawed Cycles: A Retrospective Cohort Study. International Journal Of Women's Health 2024, 16: 1067-1077. PMID: 38884053, PMCID: PMC11177859, DOI: 10.2147/ijwh.s456706.Peer-Reviewed Original ResearchFrozen-thawed embryo transfer cyclesEmbryo transfer cyclesPreterm birth rateLive birth rateDays of progesterone exposureRetrospective cohort studyD6 blastocystsTransfer cyclesProgesterone exposureCohort studyGroup BGroup ANatural cycle frozen-thawed embryo transferFrozen-thawed embryo transferBirth rateSingle-blastocyst transferFrozen-thawed cyclesNatural cycle protocolPreterm riskPregnancy outcomesEmbryo transferBlastocystSubgroup analysisReproductive outcomesDay 7Congenital interruption between the ampulla and fimbria of the fallopian tube: case report
Dong X, Zhao S, Liu P, Yu Q, Yan L. Congenital interruption between the ampulla and fimbria of the fallopian tube: case report. AJOG Global Reports 2024, 4: 100353. PMID: 38818346, PMCID: PMC11137536, DOI: 10.1016/j.xagr.2024.100353.Peer-Reviewed Original ResearchFallopian tubeLeft fallopian tubeImprove pregnancy outcomesSurgical management optionsPostoperative deliveryUrological malformationsPregnancy outcomesTubal ligationCongenital interruptionRenal tractCase reportSecondary infertilityRight sideShandong UniversityFimbriaeMalformationsAmpullaManagement optionsSalpingectomyHysteroscopySalpingostomyHydrosalpinxLaparoscopyPregnancySurgeryPlatelet rich plasma alleviates endometritis induced by lipopolysaccharide in mice via inhibiting TLR4/NF‐κB signaling pathway
Liu X, Wang Y, Wen X, Hao C, Ma J, Yan L. Platelet rich plasma alleviates endometritis induced by lipopolysaccharide in mice via inhibiting TLR4/NF‐κB signaling pathway. American Journal Of Reproductive Immunology 2024, 91: e13833. PMID: 38467595, DOI: 10.1111/aji.13833.Peer-Reviewed Original ResearchConceptsPlatelet-rich plasmaPlatelet-rich plasma treatmentTLR4/NF-kB pathwayUterine tissuePlatelet-rich-plasma intrauterine infusionMouse model of endometritisRich plasmaEffect of platelet-rich plasmaInfiltration of inflammatory cellsProduction of proinflammatory cytokinesNitric oxideExpression of TNF-aHematoxylin-eosin stainingProtective effect of platelet-rich plasmaSignaling pathwayAnti-inflammatory effectsIntrauterine perfusionSuppressed LPS-induced activationTLR4/NF-kB signaling pathwayProinflammatory chemokinesReal-time PCRConcentrations of nitric oxideInflammatory cellsProinflammatory cytokinesOccurrence of infertilityPretreatment level of serum sialic acid predicts both qualitative and quantitative bone metastases of prostate cancer
Sun J, Tian T, Wang N, Jing X, Qiu L, Cui H, Liu Z, Liu J, Yan L, Li D. Pretreatment level of serum sialic acid predicts both qualitative and quantitative bone metastases of prostate cancer. Frontiers In Endocrinology 2024, 15: 1338420. PMID: 38384968, PMCID: PMC10880016, DOI: 10.3389/fendo.2024.1338420.Peer-Reviewed Original ResearchConceptsHigh-volume diseasePresence of bone metastasesSerum sialic acidBone metastasesProstate-specific antigenProstate cancer patientsProstate cancerArea under the curveCut-off valueReceiver operating characteristicAssociated with high volume diseasePredictors of bone metastasisLevels of serum sialic acidClinical parameters of patientsDiagnosis of prostate cancerMetastasis of prostate cancerReceiver operating characteristic curve analysisBone metastasis of prostate cancerDiagnosed PCa patientsMultivariate logistic regression analysisSerum SA levelsMann-Whitney U testParameters of patientsLogistic regression analysisLevels of alkaline phosphatase
2023
Pregnancy outcomes of 4 endometrial preparation protocols in adenomyosis patients with thin endometrium during frozen embryo transfer: a retrospective cohort study
Yu Y, Zhang X, Xu X, Yan L, Zhang Y. Pregnancy outcomes of 4 endometrial preparation protocols in adenomyosis patients with thin endometrium during frozen embryo transfer: a retrospective cohort study. Global Reproductive Health 2023, 9: e0079. DOI: 10.1097/grh.0000000000000079.Peer-Reviewed Original ResearchEndometrial preparation protocolsFrozen embryo transferHormone replacement therapy groupReplacement therapy groupThin endometriumPregnancy outcomesInfant complicationsMiscarriage ratePregnancy rateEmbryo transferTherapy groupDifferent endometrial preparation protocolsGonadotropin-releasing hormone agonistFull-term pregnancy rateEarly miscarriage rateLate miscarriage rateNatural cycle treatmentClinical pregnancy rateRetrospective cohort studyReproductive Hospital AffiliatedEmbryologic characteristicsAdenomyosis patientsCohort studyHormone agonistLivebirth rateReproductive outcomes of single frozen-thawed embryo transfer in patients with endometriosis after preimplantation genetic testing
Qu H, Lv H, Kang Y, Yan L, Du Y. Reproductive outcomes of single frozen-thawed embryo transfer in patients with endometriosis after preimplantation genetic testing. Journal Of Assisted Reproduction And Genetics 2023, 41: 429-435. PMID: 38079077, PMCID: PMC10894775, DOI: 10.1007/s10815-023-02996-5.Peer-Reviewed Original ResearchPreimplantation genetic testingControl groupClinical pregnancyBiochemical pregnancyClinical abortionsEndometriosis groupLive birthsReproductive outcomesEmbryo transferSingle frozen-thawed embryo transferBlastocyst frozen embryo transfersMethodsThis retrospective cohort studyFrozen-thawed embryo transferGenetic testingRetrospective cohort studyPremature birth rateData of patientsFrozen embryo transferQuality of oocytesReproductive hospitalCohort studyPregnancy outcomesEndometrial receptivityPremature birthResultsA totalComparing histology between prostate cognitive fusion targeted biopsy and radical prostatectomy: exploring risk factors of Gleason score upgrading in Chinese patients
Zheng T, Sun H, Tang Y, Bi K, Zeng Y, Wang J, Yan L. Comparing histology between prostate cognitive fusion targeted biopsy and radical prostatectomy: exploring risk factors of Gleason score upgrading in Chinese patients. Journal Of Cancer Research And Clinical Oncology 2023, 149: 18029-18037. PMID: 37979056, DOI: 10.1007/s00432-023-05506-3.Peer-Reviewed Original ResearchDecision curve analysisMultivariable logistic regression analysisBiopsy Gleason scoreGleason scoreLogistic regression analysisChinese patientsRadical prostatectomyCOG-TBProstate volumeTumor locationRisk factorsTumor percentageBiopsy tissuePostoperative Gleason scorePatient treatment decisionsRegression analysisEffective treatment planPathological predictorsExcellent discriminatory powerTreatment decisionsCognitive fusionPatientsTreatment planSignificant associationDiscriminatory powerCognitive fusion-targeted biopsy versus transrectal ultrasonography-guided systematic biopsy: comparison and analysis of the risk of Gleason score upgrading
Zheng T, Bi K, Tang Y, Zeng Y, Wang J, Yan L. Cognitive fusion-targeted biopsy versus transrectal ultrasonography-guided systematic biopsy: comparison and analysis of the risk of Gleason score upgrading. International Urology And Nephrology 2023, 56: 981-988. PMID: 37875704, DOI: 10.1007/s11255-023-03848-y.Peer-Reviewed Original ResearchBody mass indexFusion-targeted biopsyGleason scoreProstate volumePredictive factorsSystematic biopsyBiopsy modalityMultivariable logistic regressionSignificant predictive factorsChi-square testFinal histopathologyMultivariable analysisMass indexChinese patientsBiopsyPatientsFinal enrollmentLogistic regressionScoresConcordanceNotable disparitiesAgeModalitiesFactorsHistopathology6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio) Hexanol Inhibits Proliferation and Induces Apoptosis of Endometriosis by Regulating Glutathione S-Transferase Mu Class 4
Liu W, Cheng L, Du Y, Liu X, Ma J, Yan L. 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio) Hexanol Inhibits Proliferation and Induces Apoptosis of Endometriosis by Regulating Glutathione S-Transferase Mu Class 4. Reproductive Sciences 2023, 30: 2945-2961. PMID: 36928896, DOI: 10.1007/s43032-023-01207-x.Peer-Reviewed Original ResearchConceptsNormal endometrial stromal cellsEndometrial stromal cellsMatrix metalloproteinase-9Cell Counting Kit-8Endometriosis patientsPrimary endometrial stromal cellsStromal cellsTreatment of endometriosisProgression of endometriosisExpression of Nrf2Kelch-like ECHCounting Kit-8Apoptotic protein BaxCell nuclear antigenOxidative stress-induced apoptosisChronic inflammationClass 4Healthy controlsInhibits cell growthPrognostic markerChronic diseasesMetalloproteinase-9SiRNA-mediated knockdownEndometriosisKeap1 expressionThe order flow cost of index rolling in commodity futures markets
Irwin, Scott H., Sanders, Dwight R., and Yan, Lei. 2023. “ The Order Flow Cost of Index Rolling in Commodity Futures Markets.” Applied Economic Perspectives and Policy 45(2): 1025–1050.Peer-Reviewed Original ResearchNonlinear responses of crude oil prices to the US dollar exchange rates: the role of inventories
Hu, Z., Yan, L. Nonlinear responses of crude oil prices to the US dollar exchange rates: the role of inventories. Empir Econ (2023).Peer-Reviewed Original Research
2022
Sunshine vs. predatory trading effects in commodity futures markets: New evidence from index rebalancing
Lei Yan, Scott H. Irwin, Dwight R. Sanders, Sunshine vs. predatory trading effects in commodity futures markets: New evidence from index rebalancing, Journal of Commodity Markets, Volume 26, 2022, 100195.Peer-Reviewed Original Research