Platelet rich plasma alleviates endometritis induced by lipopolysaccharide in mice via inhibiting TLR4/NF‐κB signaling pathway
Liu X, Wang Y, Wen X, Hao C, Ma J, Yan L. Platelet rich plasma alleviates endometritis induced by lipopolysaccharide in mice via inhibiting TLR4/NF‐κB signaling pathway. American Journal Of Reproductive Immunology 2024, 91: e13833. PMID: 38467595, DOI: 10.1111/aji.13833.Peer-Reviewed Original ResearchConceptsPlatelet-rich plasmaPlatelet-rich plasma treatmentTLR4/NF-kB pathwayUterine tissuePlatelet-rich-plasma intrauterine infusionMouse model of endometritisRich plasmaEffect of platelet-rich plasmaInfiltration of inflammatory cellsProduction of proinflammatory cytokinesNitric oxideExpression of TNF-aHematoxylin-eosin stainingProtective effect of platelet-rich plasmaSignaling pathwayAnti-inflammatory effectsIntrauterine perfusionSuppressed LPS-induced activationTLR4/NF-kB signaling pathwayProinflammatory chemokinesReal-time PCRConcentrations of nitric oxideInflammatory cellsProinflammatory cytokinesOccurrence of infertility