2024
Highly expressed lncRNA H19 in endometriosis promotes aerobic glycolysis and histone lactylation
Wen X, Zhang J, Xu Z, Li M, Dong X, Du Y, Xu Z, Yan L. Highly expressed lncRNA H19 in endometriosis promotes aerobic glycolysis and histone lactylation. Reproduction 2024, 168: e240018. PMID: 38744310, PMCID: PMC11301422, DOI: 10.1530/rep-24-0018.Peer-Reviewed Original ResearchConceptsAbnormal glucose metabolismIncreased aerobic glycolysisAerobic glycolysisHistone lactylationGlucose metabolismHistone lactylation levelsEndometriosis tissueH19 expressionEctopic endometriosis tissueHuman endometrial stromal cellsEndometriosis mouse modelCell proliferationPathogenesis of endometriosisProtein levels of enzymesProgression of endometriosisLevels of aerobic glycolysisEndometrial stromal cells
2023
6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio) Hexanol Inhibits Proliferation and Induces Apoptosis of Endometriosis by Regulating Glutathione S-Transferase Mu Class 4
Liu W, Cheng L, Du Y, Liu X, Ma J, Yan L. 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio) Hexanol Inhibits Proliferation and Induces Apoptosis of Endometriosis by Regulating Glutathione S-Transferase Mu Class 4. Reproductive Sciences 2023, 30: 2945-2961. PMID: 36928896, DOI: 10.1007/s43032-023-01207-x.Peer-Reviewed Original ResearchConceptsNormal endometrial stromal cellsEndometrial stromal cellsMatrix metalloproteinase-9Cell Counting Kit-8Endometriosis patientsPrimary endometrial stromal cellsStromal cellsTreatment of endometriosisProgression of endometriosisExpression of Nrf2Kelch-like ECHCounting Kit-8Apoptotic protein BaxCell nuclear antigenOxidative stress-induced apoptosisChronic inflammationClass 4Healthy controlsInhibits cell growthPrognostic markerChronic diseasesMetalloproteinase-9SiRNA-mediated knockdownEndometriosisKeap1 expression