2019
Teleneurology Consultations for Prognostication and Brain Death Diagnosis
Girkar U, Palacios R, Gupta A, Schwamm L, Singla P, May H, Estrada J, Whitney C, Matiello M. Teleneurology Consultations for Prognostication and Brain Death Diagnosis. Telemedicine Journal And E-Health 2019, 26: 482-486. PMID: 31503539, DOI: 10.1089/tmj.2019.0033.Peer-Reviewed Original ResearchConceptsBrain deathNeurology consultationIntensive care unitBrain death diagnosisPresence of apneaGood inter-rater reliabilityNeurologic prognosisTeleneurology consultationsApnea testingBrainstem reflexesCare unitNeurologic examinationBedside teamCardiac arrestBrain injuryComatose stateInter-rater reliabilityDeath diagnosisConsensus criteriaAmerican AcademyRemote neurologistDiagnosisDeathStandardized scalesConsultation
2015
In Acute Stroke, Can CT Perfusion-Derived Cerebral Blood Volume Maps Substitute for Diffusion-Weighted Imaging in Identifying the Ischemic Core?
Copen W, Morais L, Wu O, Schwamm L, Schaefer P, González R, Yoo A. In Acute Stroke, Can CT Perfusion-Derived Cerebral Blood Volume Maps Substitute for Diffusion-Weighted Imaging in Identifying the Ischemic Core? PLOS ONE 2015, 10: e0133566. PMID: 26193486, PMCID: PMC4508041, DOI: 10.1371/journal.pone.0133566.Peer-Reviewed Original ResearchConceptsComputed tomography perfusion imagingDiffusion-weighted magnetic resonance imagingCerebral blood volumeInfarct volumeSensitivity/specificityCBV mapsDWI lesionsIschemic coreCore lesionsDWI-positive patientsRegional cerebral blood volumeAcute ischemic strokeFinal infarct volumeTreatment of patientsTomography perfusion imagingPresence of infarctionMagnetic resonance imagingDiffusion-weighted imagingAcute strokeIschemic strokeSymptom onsetLesion volumeIndividual patientsInter-rater agreementPatients
2014
The TeleStroke Mimic (TM)‐Score: A Prediction Rule for Identifying Stroke Mimics Evaluated in a Telestroke Network
Ali SF, Viswanathan A, Singhal AB, Rost NS, Forducey PG, Davis LW, Schindler J, Likosky W, Schlegel S, Solenski N, Schwamm LH, Network O. The TeleStroke Mimic (TM)‐Score: A Prediction Rule for Identifying Stroke Mimics Evaluated in a Telestroke Network. Journal Of The American Heart Association 2014, 3: e000838. PMID: 24958778, PMCID: PMC4309074, DOI: 10.1161/jaha.114.000838.Peer-Reviewed Original ResearchMeSH KeywordsAgedBrain IschemiaDecision Support TechniquesFemaleHumansMaleModels, StatisticalProspective StudiesReproducibility of ResultsStrokeTelemedicineConceptsStroke mimicsIschemic cerebrovascular diseaseTelestroke networkReceiver-operating characteristic curve analysisCurve analysisHealth Stroke ScaleVascular risk profileVascular risk factorsAcute stroke evaluationExternal validation cohortFinal clinical diagnosisLower mean ageROC curve analysisCharacteristic curve analysisStepwise logistic regressionTelestroke consultationStroke ScaleFacial weaknessConsecutive patientsDerivation cohortPrior seizuresStroke evaluationAlternate diagnosisCerebrovascular diseaseValidation cohort
2013
Risk-Standardizing Survival for In-Hospital Cardiac Arrest to Facilitate Hospital Comparisons
Chan P, Berg R, Spertus J, Schwamm L, Bhatt D, Fonarow G, Heidenreich P, Nallamothu B, Tang F, Merchant R, Investigators A. Risk-Standardizing Survival for In-Hospital Cardiac Arrest to Facilitate Hospital Comparisons. Journal Of The American College Of Cardiology 2013, 62: 601-609. PMID: 23770167, PMCID: PMC3769937, DOI: 10.1016/j.jacc.2013.05.051.Peer-Reviewed Original ResearchA Risk Score for In‐Hospital Death in Patients Admitted With Ischemic or Hemorrhagic Stroke
Smith E, Shobha N, Dai D, Olson D, Reeves M, Saver J, Hernandez A, Peterson E, Fonarow G, Schwamm L. A Risk Score for In‐Hospital Death in Patients Admitted With Ischemic or Hemorrhagic Stroke. Journal Of The American Heart Association 2013, 2: e005207. PMID: 23525444, PMCID: PMC3603253, DOI: 10.1161/jaha.112.005207.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBrain IschemiaCerebral HemorrhageChi-Square DistributionDecision Support TechniquesFemaleHospital MortalityHumansInpatientsLogistic ModelsMaleMiddle AgedMultivariate AnalysisPredictive Value of TestsRegistriesReproducibility of ResultsRisk AssessmentRisk FactorsSeverity of Illness IndexStrokeSubarachnoid HemorrhageUnited StatesConceptsStroke typeIschemic strokeIntracerebral hemorrhageRisk scoreGuidelines-Stroke databaseHealth Stroke ScaleIn-Hospital DeathRisk of deathHospital mortalityHospital deathStroke ScaleStroke admissionsIndependent predictorsHemorrhagic strokeStroke patientsC-statisticSingle risk scoreOverall populationLogistic regressionPatientsValidation sampleMortalityDeathPoint scorePrediction score
2012
Rapid identification of a major diffusion/perfusion mismatch in distal internal carotid artery or middle cerebral artery ischemic stroke
Hakimelahi R, Yoo A, He J, Schwamm L, Lev M, Schaefer P, González R. Rapid identification of a major diffusion/perfusion mismatch in distal internal carotid artery or middle cerebral artery ischemic stroke. BMC Neurology 2012, 12: 132. PMID: 23121836, PMCID: PMC3519648, DOI: 10.1186/1471-2377-12-132.Peer-Reviewed Original ResearchConceptsDiffusion/perfusion mismatchDWI lesion volumeInternal carotid arteryLesion volumePerfusion mismatchConsecutive patientsCarotid arteryMiddle cerebral artery ischemic strokeDiffusion/perfusion MRITerminal internal carotid arteryProximal middle cerebral arteryDistal internal carotid arteryLarger mismatch volumeProximal MCA occlusionMiddle cerebral arteryDiffusion lesion volumeSame inclusion criteriaTerminal ICAArtery occlusionIschemic strokeMCA occlusionStroke onsetCerebral arteryStroke patientsPatient assessmentReliability of cerebral blood volume maps as a substitute for diffusion‐weighted imaging in acute ischemic stroke
deIpolyi A, Wu O, Macklin E, Schaefer P, Schwamm L, Gonzalez R, Copen W. Reliability of cerebral blood volume maps as a substitute for diffusion‐weighted imaging in acute ischemic stroke. Journal Of Magnetic Resonance Imaging 2012, 36: 1083-1087. PMID: 22761110, PMCID: PMC4110961, DOI: 10.1002/jmri.23740.Peer-Reviewed Original ResearchMeSH KeywordsAgedBlood VolumeBlood Volume DeterminationBrain IschemiaDiffusion Magnetic Resonance ImagingFemaleHumansMaleReproducibility of ResultsSensitivity and SpecificityStrokeConceptsDiffusion-weighted MRIAcute ischemic strokeCerebral blood volume mapsBlood volume mapsCBV mapsDWI lesionsIschemic strokeProportion of lesionsScan durationDiffusion-weighted imagingAcute strokeStroke onsetInfarct coreContralateral hemisphereRegional CBVMR perfusionVolume mapsLesion centerLesionsCBVStrokeShort durationPerfusionDurationLinear regressionData quality in the American Heart Association Get With The Guidelines-Stroke (GWTG-Stroke): Results from a National Data Validation Audit
Xian Y, Fonarow G, Reeves M, Webb L, Blevins J, Demyanenko V, Zhao X, Olson D, Hernandez A, Peterson E, Schwamm L, Smith E. Data quality in the American Heart Association Get With The Guidelines-Stroke (GWTG-Stroke): Results from a National Data Validation Audit. American Heart Journal 2012, 163: 392-398.e1. PMID: 22424009, DOI: 10.1016/j.ahj.2011.12.012.Peer-Reviewed Original ResearchConceptsMedical recordsDeep venous thrombosis prophylaxisPrimary stroke center certificationGWTG-Stroke hospitalsHospital academic statusStroke center certificationVenous thrombosis prophylaxisNational Stroke RegistryAmerican Heart AssociationQuality Improvement ProgramIntraclass correlationIschemic stroke volumeGuidelines-StrokeGWTG-StrokeStroke RegistryThrombosis prophylaxisNeedle timeSerum creatinineSymptom onsetHeart AssociationCenter certificationStroke volumeRegistry dataRegistry participationCategorical variables
2009
A score to predict early risk of recurrence after ischemic strokeSYMBOLSYMBOL
Ay H, Gungor L, Arsava E, Rosand J, Vangel M, Benner T, Schwamm L, Furie K, Koroshetz W, Sorensen A. A score to predict early risk of recurrence after ischemic strokeSYMBOLSYMBOL. Neurology 2009, 74: 128-135. PMID: 20018608, PMCID: PMC2809031, DOI: 10.1212/wnl.0b013e3181ca9cff.Peer-Reviewed Original ResearchConceptsRecurrent strokeEarly riskPrognostic scoreConsecutive ischemic stroke patientsComprehensive prognostic scoreTIA/strokeAcute stroke careIschemic stroke patientsPredictors of recurrenceRisk of recurrenceCox regression modelEtiologic stroke subtypesPatient management algorithmsBrain infarctsAcute settingIschemic strokeStroke subtypesIndependent predictorsStroke careStroke patientsImaging featuresPrior historySeparate cohortClinical practiceStrokeExistence of the Diffusion-Perfusion Mismatch within 24 Hours after Onset of Acute Stroke: Dependence on Proximal Arterial Occlusion
Copen W, Rezai Gharai L, Barak E, Schwamm L, Wu O, Kamalian S, Gonzalez R, Schaefer P. Existence of the Diffusion-Perfusion Mismatch within 24 Hours after Onset of Acute Stroke: Dependence on Proximal Arterial Occlusion. Radiology 2009, 250: 878-86. PMID: 19164120, DOI: 10.1148/radiol.2503080811.Peer-Reviewed Original ResearchConceptsProximal arterial occlusionAcute ischemic stroke trialsIschemic stroke trialsAcute strokeArterial occlusionStroke trialsLesion volumePerfusion-weighted magnetic resonance imagesDiffusion-perfusion mismatchMean transit time mapsTransit time mapsHIPAA-compliant studyPAO patientsAngiographic evidenceStroke onsetDose escalationTomographic angiographyEligibility criteriaPatientsInstitutional reviewMagnetic resonance imagesMR angiographyDesmoteplaseSignificant differencesAngiography
2008
Clinical- and Imaging-Based Prediction of Stroke Risk After Transient Ischemic Attack
Ay H, Arsava E, Johnston S, Vangel M, Schwamm L, Furie K, Koroshetz W, Sorensen A. Clinical- and Imaging-Based Prediction of Stroke Risk After Transient Ischemic Attack. Stroke 2008, 40: 181-186. PMID: 18948609, DOI: 10.1161/strokeaha.108.521476.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBrainComorbidityComputer SimulationDiffusion Magnetic Resonance ImagingDisease ProgressionEarly DiagnosisEmergency Medical ServicesFemaleHumansIncidenceIschemic Attack, TransientLogistic ModelsMaleMiddle AgedNeurologic ExaminationPredictive Value of TestsPrognosisReproducibility of ResultsRisk FactorsStrokeConceptsTransient ischemic attackIschemic attackStroke riskClinical featuresDiffusion-weighted imagingAcute infarctsClinical transient ischemic attackDiffusion-weighted imaging findingsEarly stroke riskRelevant clinical settingsCharacteristic curveLogistic regression modelsConsecutive patientsSymptom onsetIndependent predictorsRisk stratificationImaging findingsTherapeutic measuresHospital resourcesEarly riskClinical settingResponse criteriaPredictive instrumentStrokeSubsequent strokeRole of Recanalization in Acute Stroke Outcome: Rationale for a CT Angiogram-Based “Benefit of Recanalization” Model
Rosenthal E, Schwamm L, Roccatagliata L, Coutts S, Demchuk A, Schaefer P, Gonzalez R, Hill M, Halpern E, Lev M. Role of Recanalization in Acute Stroke Outcome: Rationale for a CT Angiogram-Based “Benefit of Recanalization” Model. American Journal Of Neuroradiology 2008, 29: 1471-1475. PMID: 18599577, PMCID: PMC8119059, DOI: 10.3174/ajnr.a1153.Peer-Reviewed Original ResearchConceptsOnly independent predictorLesion volumeComplete recanalizationRecanalization statusClinical outcomesNIHSS scoreIndependent predictorsIncomplete recanalizationCTA-SI Alberta Stroke Program Early CT ScoreAcute middle cerebral artery strokeAlberta Stroke Program Early CT ScoreHealth Stroke Scale scoreMedian admission NIHSS scoreMiddle cerebral artery strokeCT angiographic source imagesAcute stroke outcomeAdmission National InstitutesBenefit of recanalizationEarly successful recanalizationMCA M1 occlusionRole of recanalizationStroke Scale scoreAdmission NIHSS scoreMRS score 0CT/CTAAn Acute Ischemic Stroke Classification Instrument That Includes CT or MR Angiography: The Boston Acute Stroke Imaging Scale
Torres-Mozqueda F, He J, Yeh I, Schwamm L, Lev M, Schaefer P, González R. An Acute Ischemic Stroke Classification Instrument That Includes CT or MR Angiography: The Boston Acute Stroke Imaging Scale. American Journal Of Neuroradiology 2008, 29: 1111-1117. PMID: 18467521, PMCID: PMC8118840, DOI: 10.3174/ajnr.a1000.Peer-Reviewed Original ResearchConceptsAlberta Stroke Program Early CT ScoreAcute ischemic strokeMinor stroke groupIschemic strokeMajor strokeMinor strokeStroke groupNoncontrast CTBoston Acute Stroke Imaging ScaleProximal cerebral artery occlusionMR angiographyCerebral artery occlusionLength of hospitalizationClassification instrumentCTA patientsArtery occlusionDischarge dispositionConsecutive patientsParenchymal ischemiaCT scorePatient outcomesStroke survivorsRehabilitation facilityPatientsStroke
2004
Diffusion tensor imaging as potential biomarker of white matter injury in diffuse axonal injury.
Huisman T, Schwamm L, Schaefer P, Koroshetz W, Shetty-Alva N, Ozsunar Y, Wu O, Sorensen A. Diffusion tensor imaging as potential biomarker of white matter injury in diffuse axonal injury. American Journal Of Neuroradiology 2004, 25: 370-6. PMID: 15037457, PMCID: PMC8158566.Peer-Reviewed Original ResearchConceptsGlasgow Coma ScaleDiffusion tensor imagingTraumatic brain injuryRankin scoreInternal capsuleApparent diffusion coefficientADC valuesFA valuesWhite matter injuryHealthy control subjectsDiffuse axonal injuryCorresponding ADC valuesFractional anisotropy valuesNew MR imaging techniquesTBI correlatesComa ScaleClinical scoresAxonal injuryControl subjectsBrain injuryClinical markersMR imaging techniquesTissue injuryBrain ultrastructureWhite matter
2002
CT Angiography With Whole Brain Perfused Blood Volume Imaging
Ezzeddine M, Lev M, McDonald C, Rordorf G, Oliveira-Filho J, Aksoy F, Farkas J, Segal A, Schwamm L, Gonzalez R, Koroshetz W. CT Angiography With Whole Brain Perfused Blood Volume Imaging. Stroke 2002, 33: 959-966. PMID: 11935044, DOI: 10.1161/hs0402.105388.Peer-Reviewed Original ResearchConceptsOxfordshire Community Stroke Project classificationCTA/CTPNoncontrast CTCTP imagingInfarct localizationRapid CT scanningAcute stroke treatmentAcute stroke patientsInitial clinical assessmentMajor intracranial vesselsCTA source imagesVascular phase imagesSteady-state administrationProject classificationParenchymal phase imagesOrg 10172Oxfordshire classificationTOAST classificationAcute strokeStroke neurologistsStroke treatmentStroke patientsBlood volume imagingClinical examinationInfarct location
1999
Role for Telemedicine in Acute Stroke
Shafqat S, Kvedar J, Guanci M, Chang Y, Schwamm L. Role for Telemedicine in Acute Stroke. Stroke 1999, 30: 2141-2145. PMID: 10512919, DOI: 10.1161/01.str.30.10.2141.Peer-Reviewed Original ResearchConceptsNIH Stroke ScaleNIHSS scoreStroke neurologistsStroke ScaleAcute strokePatient's bedsideAcute stroke assessmentTotal NIHSS scoreAcute stroke treatmentEvaluation of patientsReliable clinical instrumentIschemic strokeStroke treatmentClinical outcomesStroke specialistsStroke expertiseBedside examinationStroke assessmentBedside assessmentKappa coefficientTelemedicine linkPatientsBedsideClinical instrumentsStroke