2010
Management of Thrombolysis-Associated Symptomatic Intracerebral Hemorrhage
Goldstein J, Marrero M, Masrur S, Pervez M, Barrocas A, Abdullah A, Oleinik A, Rosand J, Smith E, Dzik W, Schwamm L. Management of Thrombolysis-Associated Symptomatic Intracerebral Hemorrhage. JAMA Neurology 2010, 67: 965-969. PMID: 20697046, PMCID: PMC3690951, DOI: 10.1001/archneurol.2010.175.Peer-Reviewed Original ResearchConceptsSymptomatic intracerebral hemorrhageIntra-arterial thrombolysisHospital mortalityIntracerebral hemorrhageHealth Stroke Scale scoreIntravenous tissue plasminogen activatorGuidelines-Stroke databaseStroke Scale scoreAcute ischemic strokeMultivariable logistic regressionFresh frozen plasmaTissue plasminogen activatorMulticenter registryAcute strokeDevastating complicationIschemic strokeIndependent predictorsThrombolytic therapyFrozen plasmaAppropriate treatmentRetrospective analysisPatientsScale scoreCoagulopathyThrombolysis
2008
Warfarin Reversal in Anticoagulant-Associated Intracerebral Hemorrhage
Goldstein J, Rosand J, Schwamm L. Warfarin Reversal in Anticoagulant-Associated Intracerebral Hemorrhage. Neurocritical Care 2008, 9: 277-283. PMID: 18214714, DOI: 10.1007/s12028-008-9049-z.Peer-Reviewed Original ResearchConceptsFresh frozen plasmaIntravenous vitamin KProthrombin complex concentrateIntracerebral hemorrhageVitamin KWarfarin reversalClinical trialsCoagulation factorsCoagulation factor productsHalf of patientsMajority of survivorsDependent coagulation factorsHospital presentationDefinitive therapyTreatment optionsComplex concentrateAdjunct agentFrozen plasmaPermanent disabilityProcoagulant effectTreatment strategiesExpert guidelinesFactor VIIReal-world settingFactor products