2022
Rationale and design of a stepped wedge cluster randomised trial to improve acute reperfusion treatment quality for stroke: IMPROVE stroke care in China
Li Z, Wang C, Zhang X, Zong L, Zhou H, Gu H, Jiang Y, Pan Y, Meng X, Zhou Q, Zhao H, Yang X, Wang M, Xiong Y, Zhao X, Wang Y, Liu L, Ma X, Morgan L, Xian Y, Schwamm L, Wang Y. Rationale and design of a stepped wedge cluster randomised trial to improve acute reperfusion treatment quality for stroke: IMPROVE stroke care in China. Stroke And Vascular Neurology 2022, 7: 451-456. PMID: 35354662, PMCID: PMC9614172, DOI: 10.1136/svn-2021-001461.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeIntravenous thrombolysisReperfusion therapyEndovascular thrombectomyEligible patientsPrimary outcomeWedge clusterQuality improvement interventionsMixed-effects logistic regressionTreatment qualityIntraclass correlation coefficientReperfusion treatmentHospital delayIschemic strokeStroke centersTreat principleStroke careEfficacy analysisChina trialEffective treatmentNumber of casesImprovement interventionsPatientsComprehensive interventionLogistic regression
2020
Probing the Effective Treatment Thresholds for Alteplase in Acute Ischemic Stroke With Regression Discontinuity Designs
Naidech A, Lawlor P, Xu H, Fonarow G, Xian Y, Smith E, Schwamm L, Matsouaka R, Prabhakaran S, Marinescu I, Kording K. Probing the Effective Treatment Thresholds for Alteplase in Acute Ischemic Stroke With Regression Discontinuity Designs. Frontiers In Neurology 2020, 11: 961. PMID: 32982952, PMCID: PMC7492202, DOI: 10.3389/fneur.2020.00961.Peer-Reviewed Original ResearchTreatment thresholdOutcomes of patientsAcute ischemic strokeCohort of patientsPatient demographic characteristicsIschemic strokeControlled TrialsStroke interventionClinical outcomesClinical careEffective treatmentLarger sample sizeMedical interventionsPatientsDemographic characteristicsGold standardAlteplaseInterventionTreatmentContinuous variablesOutcomesLimited populationSample sizeTreatment timePotential reasons