2017
Multiparametric Magnetic Resonance Imaging for Prediction of Parenchymal Hemorrhage in Acute Ischemic Stroke After Reperfusion Therapy
Nael K, Knitter J, Jahan R, Gornbein J, Ajani Z, Feng L, Meyer B, Schwamm L, Yoo A, Marshall R, Meyers P, Yavagal D, Wintermark M, Liebeskind D, Guzy J, Starkman S, Saver J, Kidwell C. Multiparametric Magnetic Resonance Imaging for Prediction of Parenchymal Hemorrhage in Acute Ischemic Stroke After Reperfusion Therapy. Stroke 2017, 48: 664-670. PMID: 28138001, PMCID: PMC5325250, DOI: 10.1161/strokeaha.116.014343.Peer-Reviewed Original ResearchConceptsCerebral blood volumeAcute ischemic strokeParenchymal hemorrhageReperfusion therapyIschemic strokeReceiver-operating characteristic curve analysisApparent diffusion coefficientMultiparametric magnetic resonance imagingPretreatment magnetic resonanceMagnetic resonance perfusionValues of CBVCharacteristic curve analysisApparent diffusion coefficient (ADC) valuesMagnetic resonance imagingIndependent predictorsIschemic coreRisk stratificationUnivariate analysisClinical trialsMicrovascular permeabilityBlood volumeInfarction corePatientsResonance imagingDiagnostic accuracy
2015
In Acute Stroke, Can CT Perfusion-Derived Cerebral Blood Volume Maps Substitute for Diffusion-Weighted Imaging in Identifying the Ischemic Core?
Copen W, Morais L, Wu O, Schwamm L, Schaefer P, González R, Yoo A. In Acute Stroke, Can CT Perfusion-Derived Cerebral Blood Volume Maps Substitute for Diffusion-Weighted Imaging in Identifying the Ischemic Core? PLOS ONE 2015, 10: e0133566. PMID: 26193486, PMCID: PMC4508041, DOI: 10.1371/journal.pone.0133566.Peer-Reviewed Original ResearchConceptsComputed tomography perfusion imagingDiffusion-weighted magnetic resonance imagingCerebral blood volumeInfarct volumeSensitivity/specificityCBV mapsDWI lesionsIschemic coreCore lesionsDWI-positive patientsRegional cerebral blood volumeAcute ischemic strokeFinal infarct volumeTreatment of patientsTomography perfusion imagingPresence of infarctionMagnetic resonance imagingDiffusion-weighted imagingAcute strokeIschemic strokeSymptom onsetLesion volumeIndividual patientsInter-rater agreementPatients
2006
First-pass quantitative CT perfusion identifies thresholds for salvageable penumbra in acute stroke patients treated with intra-arterial therapy.
Schaefer P, Roccatagliata L, Ledezma C, Hoh B, Schwamm L, Koroshetz W, Gonzalez R, Lev M. First-pass quantitative CT perfusion identifies thresholds for salvageable penumbra in acute stroke patients treated with intra-arterial therapy. American Journal Of Neuroradiology 2006, 27: 20-5. PMID: 16418350, PMCID: PMC7976067.Peer-Reviewed Original ResearchConceptsCerebral blood volumeAcute stroke patientsCT perfusionStroke patientsCBF ratioGray matterWhite matterAbsolute cerebral blood volumeCBV ratioIntra-arterial therapyIschemic brain tissueQuantitative CT perfusionDynamic CT perfusionIA therapyRecanalization therapyStroke onsetSalvageable penumbraInfarct coreIschemic tissueUninvolved regionsIschemic regionBlood volumeCBF valuesPatientsBrain tissue
2003
Whole-Brain CT Perfusion Measurement of Perfused Cerebral Blood Volume in Acute Ischemic Stroke: Probability Curve for Regional Infarction
Hunter G, Silvennoinen H, Hamberg L, Koroshetz W, Buonanno F, Schwamm L, Rordorf G, Gonzalez R. Whole-Brain CT Perfusion Measurement of Perfused Cerebral Blood Volume in Acute Ischemic Stroke: Probability Curve for Regional Infarction. Radiology 2003, 227: 725-30. PMID: 12728181, DOI: 10.1148/radiol.2273012169.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeCerebral blood volumeIschemic strokeBlood volumeMajor arterial occlusionLikelihood of infarctionLogistic regression analysisPositive predictive valueCT perfusion measurementsAcute strokeCerebral infarctionArterial occlusionIntracranial hemorrhagePerfusion scanCore infarctionPCBVInfarctionPositive followProbability of survivalRegional infarctionPredictive valuePatientsStrokePerfusion measurementsRegression analysis
2002
Predicting cerebral ischemic infarct volume with diffusion and perfusion MR imaging.
Schaefer P, Hunter G, He J, Hamberg L, Sorensen A, Schwamm L, Koroshetz W, Gonzalez R. Predicting cerebral ischemic infarct volume with diffusion and perfusion MR imaging. American Journal Of Neuroradiology 2002, 23: 1785-94. PMID: 12427640, PMCID: PMC8185825.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBlood Flow VelocityBrain IschemiaCerebral InfarctionCerebrovascular CirculationDiffusion Magnetic Resonance ImagingFalse Positive ReactionsFemaleFollow-Up StudiesHumansIschemic Attack, TransientMagnetic Resonance AngiographyMaleMiddle AgedObserver VariationPredictive Value of TestsSensitivity and SpecificityTime FactorsConceptsCerebral blood flowCerebral blood volumeFinal infarct volumeInfarct volumeDW imagingLesion growthAcute ischemic stroke symptomsHemodynamic imagesAcute ischemic infarctionIschemic infarct volumeInitial clinical assessmentFinal discharge diagnosisFinal infarct sizeHours of onsetIschemic stroke symptomsPerfusion MR imagingPerfusion-weighted imagesAcute strokeIschemic infarctionStroke symptomsAcute infarctionAcute lesionsDischarge diagnosisInfarct sizeAltered perfusion
2001
Heterogeneous spatial-temporal evolution of DWI/PWI in human cerebral ischemia
Wu O, Schwamm L, Koroshetz W, Gonzalez R, Pan V, Benner T, Copen W, Ostergaard L, Sorensen A. Heterogeneous spatial-temporal evolution of DWI/PWI in human cerebral ischemia. Stroke 2001, 32: 348-348. DOI: 10.1161/str.32.suppl_1.348-d.Peer-Reviewed Original ResearchCerebral blood flowHuman cerebral ischemiaDWI/PWICerebral blood volumeMean transit timeApparent diffusion coefficientFractional anisotropyCerebral ischemiaRim tissueHuman ischemic strokeElevated fractional anisotropyTwo-sample t-testDWI abnormalitiesInitial DWIIschemic strokeMCA territoryAcute stageIschemic coreSalvageable tissueIntralesional heterogeneityIschemic tissueBlood flowBlood volumeRisk tissuePatients
1999
Diffusion- and Perfusion-Weighted Imaging in Vasospasm After Subarachnoid Hemorrhage
Rordorf G, Koroshetz W, Copen W, Gonzalez G, Yamada K, Schaefer P, Schwamm L, Ogilvy C, Sorensen A. Diffusion- and Perfusion-Weighted Imaging in Vasospasm After Subarachnoid Hemorrhage. Stroke 1999, 30: 599-605. PMID: 10066858, DOI: 10.1161/01.str.30.3.599.Peer-Reviewed Original ResearchConceptsRelative cerebral blood flowRelative cerebral blood volumeAngiographic vasospasmIschemic injurySymptomatic vasospasmNeurological deficitsClinical signsSevere angiographic vasospasmCerebral tissue perfusionEarly ischemic injurySubarachnoid hemorrhage patientsCerebral blood flowIntravenous contrast bolusPerfusion-Weighted ImagingCerebral blood volumeDWI abnormalitiesAsymptomatic patientsHemodynamic abnormalitiesNormal angiogramsAngiographic spasmImaging abnormalitiesIschemic lesionsHemorrhage patientsSubarachnoid hemorrhageClinical managementHyperacute Stroke: Simultaneous Measurement of Relative Cerebral Blood Volume, Relative Cerebral Blood Flow, and Mean Tissue Transit Time
Sorensen A, Copen W, Ostergaard L, Buonanno F, Gonzalez R, Rordorf G, Rosen B, Schwamm L, Weisskoff R, Koroshetz W. Hyperacute Stroke: Simultaneous Measurement of Relative Cerebral Blood Volume, Relative Cerebral Blood Flow, and Mean Tissue Transit Time. Radiology 1999, 210: 519-27. PMID: 10207439, DOI: 10.1148/radiology.210.2.r99fe06519.Peer-Reviewed Original ResearchConceptsRelative cerebral blood flowCerebral blood flowRelative cerebral blood volumeCerebral blood volumeBlood flowBlood volumeTissue transit timeLesion volumeMR imagingDiffusion findingsAcute lesion volumesCompensatory hemodynamic responseHemodynamic MR imagingCerebral ischemic strokeOnset of symptomsInitial blood flowAltered blood flowBlood volume mapsFunctional magnetic resonance imagingMagnetic resonance imagingTransit time mapsBlood flow mapsInitial blood volumeInfarct volumeHemodynamic abnormalities
1998
Regional Ischemia and Ischemic Injury in Patients With Acute Middle Cerebral Artery Stroke as Defined by Early Diffusion-Weighted and Perfusion-Weighted MRI
Rordorf G, Koroshetz W, Copen W, Cramer S, Schaefer P, Budzik R, Schwamm L, Buonanno F, Sorensen A, Gonzalez G. Regional Ischemia and Ischemic Injury in Patients With Acute Middle Cerebral Artery Stroke as Defined by Early Diffusion-Weighted and Perfusion-Weighted MRI. Stroke 1998, 29: 939-943. PMID: 9596239, DOI: 10.1161/01.str.29.5.939.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultAgedAged, 80 and overArterial Occlusive DiseasesBrain IschemiaCerebral ArteriesCerebral InfarctionCerebrovascular CirculationCerebrovascular DisordersDiffusionFemaleHumansMagnetic Resonance AngiographyMagnetic Resonance ImagingMaleMiddle AgedPerfusionReperfusion InjuryConceptsPerfusion-weighted imagingMiddle cerebral artery strokeDiffusion-weighted imagingCerebral blood volumeMCA strokeArtery strokeMR angiographyCBV abnormalityRegional ischemiaAcute middle cerebral artery strokeInitial diffusion-weighted imagingAcute stroke syndromeDistal branch occlusionDWI lesion volumeInitial DWI lesionMCA stem occlusionGroup 2 patientsMRI techniquesFinal infarct sizeFinal infarct volumeHours of onsetIntravenous contrast bolusAbnormal tissue perfusionProgression of infarctionPerfusion-Weighted MRIAssessment of cerebral perfusion and arterial anatomy in hyperacute stroke with three-dimensional functional CT: early clinical results.
Hunter G, Hamberg L, Ponzo J, Huang-Hellinger F, Morris P, Rabinov J, Farkas J, Lev M, Schaefer P, Ogilvy C, Schwamm L, Buonanno F, Koroshetz W, Wolf G, González R. Assessment of cerebral perfusion and arterial anatomy in hyperacute stroke with three-dimensional functional CT: early clinical results. American Journal Of Neuroradiology 1998, 19: 29-37. PMID: 9432154, PMCID: PMC8337333.Peer-Reviewed Original ResearchConceptsHyperacute strokeFunctional CTIschemic changesEarly clinical resultsCerebral blood volumeContrast-enhanced scansHelical CT techniqueOcclusion of vesselsHyperacute groupCerebral perfusionPBV mapsArterial anatomyPatient populationBrain stemClinical resultsCT angiogramContrast administrationRegional perfusionCT angiographyBlood volumePatientsPBV valuesWhite matterGray matterClinical feasibility