Evaluation of Recombinant Platelet Factor 4 and Protamine Sulfate for Heparin Neutralization: Clotting and Clearance Studies in Rat
Korutla L, Stewart G, Lasz E, Maione T, Niewiarowski S. Evaluation of Recombinant Platelet Factor 4 and Protamine Sulfate for Heparin Neutralization: Clotting and Clearance Studies in Rat. Thrombosis And Haemostasis 1994, 71: 609-614. PMID: 8091389, DOI: 10.1055/s-0038-1642491.Peer-Reviewed Original ResearchConceptsRecombinant platelet factor 4Platelet factor 4Protamine sulfatePartial thromboplastin timeFactor 4Heparin clearanceHeparin neutralizationThromboplastin timeVitro additionClearance studiesDifferent physiological effectsAdverse effectsRatsOrgan depositionHeparinAnticoagulant activityPhysiological effectsGreater percentageLoss of radioactivityHalf lifeHeparin-agarose chromatographyInjectionMinLarge percentageRadioactivity