1996
Mechanism of interferon action: in vivo activation of 91 kDa transcription factor.
Korutla L, Kumar R. Mechanism of interferon action: in vivo activation of 91 kDa transcription factor. Anticancer Research 1996, 16: 2789-95. PMID: 8917387.Peer-Reviewed Original ResearchConceptsLive human cellsHuman cellsSpecific cellular genesProtein tyrosine kinasesRegulation of expressionTreatment of cellsProtein phosphotyrosineCellular genesEarly biochemical eventsDistinct biological effectsTranscription factorsTyrosine phosphorylationTyrosine kinaseSodium orthovanadateBiochemical eventsCell growthInterferon actionBiological effectsPossible involvementCellsActivationVivo activationKinaseGenesPhosphorylation
1995
Inhibition of ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation by curcumin
Korutla L, Cheung J, Medelsohn J, Kumar R. Inhibition of ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation by curcumin. Carcinogenesis 1995, 16: 1741-1745. PMID: 7634398, DOI: 10.1093/carcin/16.8.1741.Peer-Reviewed Original ResearchConceptsGrowth stimulatory pathwaysTumor cell growthTime-dependent mannerAnti-proliferative strategyTyrosine phosphorylationEpidermal growth factorEpidermal growth factor receptor tyrosine phosphorylationCurcumin treatmentActivation of EGFCalcium releaseStimulatory pathwayReceptor tyrosine phosphorylationTreatment of cellsEGF receptor phosphorylationKinase inhibitorsGrowth factorSurface expressionReceptor phosphorylationHuman EGFCurcuminEGFInhibition of EGFPotent inhibitorActivationCell growth
1994
Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells
Korutla L, Kumar R. Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells. Biochimica Et Biophysica Acta 1994, 1224: 597-600. PMID: 7803521, DOI: 10.1016/0167-4889(94)90299-2.Peer-Reviewed Original ResearchConceptsReceptor's intrinsic kinase activityShort-term treatmentObserved early effectsTime-dependent mannerA431 cellsReceptor kinase activityKinase activityInhibitory effectEarly effectsAntigrowth actionEGF-induced tyrosine phosphorylationEpidermoid carcinoma A431 cellsHuman epidermoid carcinoma A431 cellsIntrinsic kinase activityEpidermal growth factor receptor kinase activityEGF receptorCurcuminCell growthCellsTyrosine phosphorylationDoseCell cycle-dependent modulation of alpha-interferon-inducible gene expression and activation of signaling components in Daudi cells.
Kumar R, Korutla L, Zhang K. Cell cycle-dependent modulation of alpha-interferon-inducible gene expression and activation of signaling components in Daudi cells. Journal Of Biological Chemistry 1994, 269: 25437-25441. PMID: 7929242, DOI: 10.1016/s0021-9258(18)47269-9.Peer-Reviewed Original ResearchMeSH Keywords2',5'-Oligoadenylate SynthetaseBase SequenceBurkitt LymphomaCell CycleDNA-Binding ProteinsEnzyme ActivationG1 PhaseGene Expression RegulationHumansInterferon-alphaJanus Kinase 1Molecular Sequence DataProtein-Tyrosine KinasesProteinsS PhaseSignal TransductionSTAT1 Transcription FactorTrans-ActivatorsTumor Cells, CulturedTYK2 KinaseConceptsTyk-2 kinaseJAK-1Synthetase proteinTyrosine phosphorylationGene expressionCell cycle-dependent modulationCell cycleCell cycle-dependent expressionCell cycle-dependent changesInducible gene expressionGene factor 3Unique expression patternCycle-dependent expressionG1/S phaseCell cycle progressionG1/SIFN-inducible gene expressionG2/M.Human Burkitt lymphoma Daudi cellsInduction of expressionG1/S blockG2/MDaudi cellsIFN-alpha-inducible genesCycle-dependent changes