2016
New Functional Tools for Antithrombogenic Activity Assessment of Live Surface Glycocalyx
Dimitrievska S, Gui L, Weyers A, Lin T, Cai C, Wu W, Tuggle CT, Sundaram S, Balestrini JL, Slattery D, Tchouta L, Kyriakides TR, Tarbell JM, Linhardt RJ, Niklason LE. New Functional Tools for Antithrombogenic Activity Assessment of Live Surface Glycocalyx. Arteriosclerosis Thrombosis And Vascular Biology 2016, 36: 1847-1853. PMID: 27386939, PMCID: PMC5283952, DOI: 10.1161/atvbaha.116.308023.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntithrombinsAorta, ThoracicBiological AssayBlood CoagulationCells, CulturedChromatography, LiquidFactor XaGlycocalyxHeparinHeparitin SulfateHuman Umbilical Vein Endothelial CellsMaleMass SpectrometryMicroscopy, Electron, TransmissionRats, Sprague-DawleyReproducibility of ResultsThrombinTime FactorsConceptsHuman umbilical vein endothelial cellsUmbilical vein endothelial cellsVein endothelial cellsNative aortaEndothelial cellsHuman umbilical vein endothelial cell monolayersCultured human umbilical vein endothelial cellsFactor XaVascular healthEndothelial cell monolayersVascular diseaseRat aortaDamaged vasculatureAnticoagulant capacityVascular communityAortaTherapeutic developmentActivity assessmentCell monolayersVascular graftsLiquid chromatography-mass spectrometry analysisNovel assayGlycocalyxAssaysNative rat aorta
2011
Decellularized tissue-engineered blood vessel as an arterial conduit
Quint C, Kondo Y, Manson RJ, Lawson JH, Dardik A, Niklason LE. Decellularized tissue-engineered blood vessel as an arterial conduit. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 9214-9219. PMID: 21571635, PMCID: PMC3107282, DOI: 10.1073/pnas.1019506108.Peer-Reviewed Original ResearchConceptsTissue-engineered vesselsBiomimetic perfusion systemArterial tissue engineeringTissue-engineered blood vesselsTissue engineering techniquesEndothelial progenitor cellsTissue engineeringRobust extracellular matrixVein graftsBiological vascular graftPorcine carotid arteriesVascular graftsTissue regenerationIntimal hyperplasiaAutologous endothelial progenitor cellsGraft wallProgenitor cellsControl vein graftsSmooth muscle cellsGraft lumenGraft occlusionArterial conduitsImproved patencyCarotid arteryPorcine smooth muscle cells