2016
Ventilation-Based Decellularization System of the Lung
Tsuchiya T, Mendez J, Calle EA, Hatachi G, Doi R, Zhao L, Suematsu T, Nagayasu T, Niklason LE. Ventilation-Based Decellularization System of the Lung. BioResearch Open Access 2016, 5: 118-126. PMID: 27186445, PMCID: PMC4860652, DOI: 10.1089/biores.2016.0012.Peer-Reviewed Original ResearchAirway groupPulmonary arteryDecellularized groupVessel groupPositive end-expiratory pressureEnd-expiratory pressureMHC class IWestern blot analysisRed blood cellsOrgan recipientsImmunohistochemical findingsNative lungPortal veinAdministration routeAlveolar wallsRat lungLungBlood leakageOrgan donationBlood cellsClass IDonated organsExtracellular matrixAirwayArtery
2010
Tissue-Engineered Lungs for in Vivo Implantation
Petersen TH, Calle EA, Zhao L, Lee EJ, Gui L, Raredon MB, Gavrilov K, Yi T, Zhuang ZW, Breuer C, Herzog E, Niklason LE. Tissue-Engineered Lungs for in Vivo Implantation. Science 2010, 329: 538-541. PMID: 20576850, PMCID: PMC3640463, DOI: 10.1126/science.1189345.Peer-Reviewed Original ResearchConceptsLung tissueLung matrixAcellular lung matrixNative lung tissueTissue-engineered lungsLung transplantationPrimary therapyAdult lung tissueAdult ratsPulmonary epitheliumVascular endotheliumFunctional lungLung regenerationVascular compartmentLungSeeded endothelial cellsMechanical characteristicsEndothelial cellsVivo implantationRatsEpitheliumTissueCellular componentsExtracellular matrixGas exchange