2019
Pharmacologic treatment options for type 1 diabetes: what’s new?
Nally LM, Sherr JL, Van Name MA, Patel AD, Tamborlane WV. Pharmacologic treatment options for type 1 diabetes: what’s new? Expert Review Of Clinical Pharmacology 2019, 12: 471-479. PMID: 30892094, PMCID: PMC6488361, DOI: 10.1080/17512433.2019.1597705.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAdjunctive therapyType 1 diabetesInsulin analoguesMimic physiologic insulin secretionGLP-1 receptor agonistsPhysiologic insulin secretionPharmacologic treatment optionsDPP-4 inhibitorsType 2 diabetesVariety of insulinBiosynthetic human insulinPotential adverse effectsSGLT1/2 inhibitorsBasal insulinPharmacologic treatmentTreatment optionsReceptor agonistInsulin secretionSGLT-2Abnormal physiologyProlonged durationTherapyDiabetesInsulinNovel drugs
2015
Gene therapy with neurogenin3, betacellulin and SOCS1 reverses diabetes in NOD mice
Li R, Buras E, Lee J, Liu R, Liu V, Espiritu C, Ozer K, Thompson B, Nally L, Yuan G, Oka K, Chang B, Samson S, Yechoor V, Chan L. Gene therapy with neurogenin3, betacellulin and SOCS1 reverses diabetes in NOD mice. Gene Therapy 2015, 22: 876-882. PMID: 26172077, PMCID: PMC4636470, DOI: 10.1038/gt.2015.62.Peer-Reviewed Original ResearchMeSH KeywordsAdenoviridaeAnimalsBasic Helix-Loop-Helix Transcription FactorsBetacellulinDiabetes Mellitus, ExperimentalFemaleGenetic TherapyImmunosuppression TherapyInsulinIslets of LangerhansIslets of Langerhans TransplantationLiverMiceMice, Inbred NODNerve Tissue ProteinsSuppressor of Cytokine Signaling 1 ProteinSuppressor of Cytokine Signaling ProteinsConceptsSuppressor of cytokine signaling 1NOD miceGene therapyModel of autoimmune diabetesDiabetic miceLineage-defining transcription factorsGlucose-stimulated insulin secretionHelper-dependent adenovirusActivated T cellsLong-term reversal of diabetesRat insulin promoterReversal of diabetesShortage of donor isletsIslet neogenesisOverexpression suppressorIslet growth factorsNeo-isletsType 1 diabetesCytokine signaling 1Transcription factorsTransfer diabetesNon-obeseTreated mice liverAutoimmune diabetesT cells