2019
Identification and Validation of a Novel Biologics Target in Triple Negative Breast Cancer
Wali VB, Patwardhan GA, Pelekanou V, Karn T, Cao J, Ocana A, Yan Q, Nelson B, Hatzis C, Pusztai L. Identification and Validation of a Novel Biologics Target in Triple Negative Breast Cancer. Scientific Reports 2019, 9: 14934. PMID: 31624295, PMCID: PMC6797726, DOI: 10.1038/s41598-019-51453-w.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsBreastCell Line, TumorCell MembraneCell ProliferationDatasets as TopicDrug DevelopmentFemaleGABA-A Receptor AntagonistsGene Expression ProfilingGene Knockdown TechniquesHumansImmunoconjugatesImmunoglobulin Fab FragmentsMaytansineMiceMolecular Targeted TherapyReceptors, GABA-ATriple Negative Breast NeoplasmsXenograft Model Antitumor AssaysConceptsTriple-negative breast cancerNegative breast cancerTNBC cell growthBreast cancerMDA-MB-468 xenograftsPotential novel therapeutic targetNovel biologic targetsNovel therapeutic targetBreast cancer tissuesReceptors/cellAntibody-drug conjugate (ADC) developmentMost normal tissuesTreatment optionsCell growthTherapeutic targetBiologic targetsNude miceCancer tissuesVivo functional assaysLow expressionNormal tissuesNovel targetCancerSignificant anticancer activityADC development
2005
A single-gene biomarker identifies breast cancers associated with immature cell type and short duration of prior breastfeeding
Symmans W, Fiterman D, Anderson S, Ayers M, Rouzier R, Dunmire V, Stec J, Valero V, Sneige N, Albarracin C, Wu Y, Ross J, Wagner P, Theriault R, Arun B, Kuerer H, Hess K, Zhang W, Hortobagyi G, Pusztai L. A single-gene biomarker identifies breast cancers associated with immature cell type and short duration of prior breastfeeding. Endocrine Related Cancer 2005, 12: 1059-1069. PMID: 16322343, DOI: 10.1677/erc.1.01051.Peer-Reviewed Original ResearchConceptsReal-time reverse transcription-polymerase chain reactionInvasive breast cancerImmature cell typesBreast cancerPrimary invasive breast cancerHigh-grade breast cancerMultivariate linear regression analysisReverse transcription-polymerase chain reactionCell typesTranscription-polymerase chain reactionShorter lifetime durationGene expressionParous womenClinicopathologic characteristicsEstrogen receptorHispanic ethnicitySeparate cohortHispanic womenElevated gene expressionLinear regression analysisLifetime historyYounger ageNeu receptorCancerBreastfeeding