2011
Recommendations from an International Consensus Conference on the Current Status and Future of Neoadjuvant Systemic Therapy in Primary Breast Cancer
Kaufmann M, von Minckwitz G, Mamounas EP, Cameron D, Carey LA, Cristofanilli M, Denkert C, Eiermann W, Gnant M, Harris JR, Karn T, Liedtke C, Mauri D, Rouzier R, Ruckhaeberle E, Semiglazov V, Symmans WF, Tutt A, Pusztai L. Recommendations from an International Consensus Conference on the Current Status and Future of Neoadjuvant Systemic Therapy in Primary Breast Cancer. Annals Of Surgical Oncology 2011, 19: 1508-1516. PMID: 22193884, DOI: 10.1245/s10434-011-2108-2.Peer-Reviewed Original ResearchConceptsNeoadjuvant systemic therapyPrimary breast cancerBreast cancerSystemic therapyBreast-conserving surgery rateLarge adjuvant trialsPathologic complete responseInflammatory breast cancerNew therapeutic regimensIntermediate end pointsInternational Consensus ConferenceClinical research groupAdjuvant trialsNew regimensPathologic responseComplete responseSurgery ratesTherapeutic regimensConsensus conferenceEnd pointTherapyCancerTrialsRegimensPanel of representatives
2007
Gene-expression microarrays provide new prognostic and predictive tests for breast cancer
Gong Y, Symmans WF, Pusztai L. Gene-expression microarrays provide new prognostic and predictive tests for breast cancer. Pharmacogenomics 2007, 8: 1359-1368. PMID: 17979510, DOI: 10.2217/14622416.8.10.1359.Peer-Reviewed Original ResearchConceptsBreast cancerSystemic therapySpecific systemic therapySystemic therapy agentsGene expression microarraysBreast cancer researchProbability of responseTherapeutic regimensClinicopathologic variablesNecessary therapyDisease outcomeIndividual patientsAccurate markerClinical decisionIndividual tumorsCancerPredictive indicatorTherapyPredictive testIndividual basisPatientsCancer researchTherapy agentsMolecular differencesRecent progression