2011
Regulation of human osteoclast development by dendritic cell‐specific transmembrane protein (DC‐STAMP)
Chiu Y, Mensah KA, Schwarz EM, Ju Y, Takahata M, Feng C, McMahon LA, Hicks DG, Panepento B, Keng PC, Ritchlin CT. Regulation of human osteoclast development by dendritic cell‐specific transmembrane protein (DC‐STAMP). Journal Of Bone And Mineral Research 2011, 27: 79-92. PMID: 21987375, PMCID: PMC3304467, DOI: 10.1002/jbmr.531.Peer-Reviewed Original ResearchConceptsDendritic cell-specific transmembrane proteinImmunoreceptor tyrosine-based inhibitory motifOC precursorsInflammatory arthritisTransmembrane proteinSH2 domain-containing tyrosine phosphataseTransmembrane receptor-like proteinErosive inflammatory arthritisCell fusionTumor giant cellsMetabolic bone diseaseReceptor-like proteinDC-STAMP expressionTyrosine-based inhibitory motifCell surface receptorsBone diseaseHuman PBMCsTyrosine phosphataseOsteoclast developmentCytoplasmic tailGiant cellsCellular transformationOC formationOsteoclastogenesisSHP-1
2010
Mediation of nonerosive arthritis in a mouse model of lupus by interferon‐α–stimulated monocyte differentiation that is nonpermissive of osteoclastogenesis
Mensah KA, Mathian A, Ma L, Xing L, Ritchlin CT, Schwarz EM. Mediation of nonerosive arthritis in a mouse model of lupus by interferon‐α–stimulated monocyte differentiation that is nonpermissive of osteoclastogenesis. Arthritis & Rheumatism 2010, 62: 1127-1137. PMID: 20131244, PMCID: PMC2854832, DOI: 10.1002/art.27312.Peer-Reviewed Original ResearchConceptsMyeloid dendritic cellsSystemic lupus erythematosusSerum-induced arthritisNZB xBone erosionDendritic cellsOsteoclast precursorsAntibody titersMouse modelAnti-dsDNA antibody titersDNA antibody titersMicrofocal computed tomographyCytokine interferon-alphaEffects of IFNalphaJaccoud's arthritisNonerosive arthritisSLE diseaseJoint inflammationLupus erythematosusAutoimmune diseasesNZW miceSerum administrationInterferon alphaFocal erosionsSLE monocytes
2009
The emerging field of osteoimmunology
Mensah KA, Li J, Schwarz EM. The emerging field of osteoimmunology. Immunologic Research 2009, 45: 100-113. PMID: 19184540, PMCID: PMC2934875, DOI: 10.1007/s12026-009-8093-x.Peer-Reviewed Original ResearchConceptsRheumatoid arthritisAdaptive immune effector cellsImmune effector cellsTreatment of autoimmuneField of osteoimmunologyMetabolic bone diseaseSkeletal systemImmune cell ontogenySubsequent effector functionsBasic science findingsEffector cellsAutoimmune diseasesInflammatory diseasesBone diseaseEffector functionsBone microenvironmentBiologic drugsDiseaseCell ontogenyBone biologyClinical applicationEffector moleculesOsteoimmunologyRecent findingsRecent studies
2008
Altered bone remodeling in psoriatic arthritis
Mensah KA, Schwarz EM, Ritchlin CT. Altered bone remodeling in psoriatic arthritis. Current Rheumatology Reports 2008, 10: 311-317. PMID: 18662512, PMCID: PMC2656567, DOI: 10.1007/s11926-008-0050-5.Peer-Reviewed Original ResearchConceptsPsoriatic arthritisTumor necrosis factor inhibitionInflammatory joint diseaseNecrosis factor inhibitionBasic science findingsInflammatory arthritisNew bone formationBone resorptionFactor inhibitionJoint diseaseBone homeostasisArthritisBone formationAltered boneSkeletal systemBone biologyDynamic organClinical applicationPivotal roleRecent studiesBoneOsteoimmunologyScience findings