2023
Impact of motion correction on [18F]-MK6240 tau PET imaging
Tiss A, Marin T, Chemli Y, Spangler-Bickell M, Gong K, Lois C, Petibon Y, Landes V, Grogg K, Normandin M, Becker A, Thibault E, Johnson K, Fakhri G, Ouyang J. Impact of motion correction on [18F]-MK6240 tau PET imaging. Physics In Medicine And Biology 2023, 68: 105015. PMID: 37116511, PMCID: PMC10278956, DOI: 10.1088/1361-6560/acd161.Peer-Reviewed Original ResearchConceptsMotion correctionPET quantitationImpact of motion correctionList-mode reconstructionMotion correction methodList-mode dataMotion-corrected imagesEffect of motion correctionVoxel displacementsPhantom experimentsOptical tracking dataLong acquisitionBrain PET scansSlow motionImage qualityPET imagingPositron emission tomographyCorrectionMotionCorrection methodRates of tau accumulationHead motionMotion metricsPhantomPositron
2018
Deterioration of Regional Lung Strain and Inflammation during Early Lung Injury
Motta-Ribeiro G, Hashimoto S, Winkler T, Baron R, Grogg K, Paula L, Santos A, Zeng C, Hibbert K, Harris R, Bajwa E, Vidal Melo M. Deterioration of Regional Lung Strain and Inflammation during Early Lung Injury. American Journal Of Respiratory And Critical Care Medicine 2018, 198: 891-902. PMID: 29787304, PMCID: PMC6173064, DOI: 10.1164/rccm.201710-2038oc.Peer-Reviewed Original ResearchMeSH KeywordsAcute Lung InjuryAnalysis of VarianceAnimalsBiopsy, NeedleBlood Gas AnalysisDisease Models, AnimalEndotoxemiaEndotoxinsFemaleFluorodeoxyglucose F18HumansImmunohistochemistryInfusions, IntravenousLinear ModelsMultivariate AnalysisPositron-Emission TomographyPulmonary AtelectasisRandom AllocationRespiration, ArtificialRespiratory Distress SyndromeRespiratory Function TestsRisk FactorsSheepTidal VolumeTime FactorsTomography, X-Ray ComputedConceptsLung injurySupine lungConsistent with clinical practiceBlood volumeF-FDG phosphorylation rateLocal neutrophilic inflammationAssociated with increased inflammationF-FDG uptakeEarly mechanical ventilationClinical practiceEarly lung injuryPositive end-expiratory pressureLung strainEnd-expiratory pressurePositron emission tomographyF-FDGUninjured lungsImaging findingsRegional inflammationNeutrophilic inflammationSystemic endotoxemiaProne positionComputed tomographyVentilated patientsIntravenous endotoxin
2017
Feasibility study of using fall‐off gradients of early and late PET scans for proton range verification
Cho J, Grogg K, Min C, Zhu X, Paganetti H, Lee H, Fakhri G. Feasibility study of using fall‐off gradients of early and late PET scans for proton range verification. Medical Physics 2017, 44: 1734-1746. PMID: 28273345, PMCID: PMC5462437, DOI: 10.1002/mp.12191.Peer-Reviewed Original ResearchConceptsProton range verificationProton rangeMonte Carlo simulationsRange verificationFall-offIn-room positron emission tomographyCarlo simulationsResidual proton rangeDose fall-offPostirradiation delayPositron emission tomography imagingSOBP beamProton beamPositron emission tomographyPositron emission tomography scanPhantom studyIn-roomFunction of depthPhantomProtonOff-setMonteAcquisition timeBeamPositron emission tomography signal
2015
Mapping 15O Production Rate for Proton Therapy Verification
Grogg K, Alpert N, Zhu X, Min C, Testa M, Winey B, Normandin M, Shih H, Paganetti H, Bortfeld T, Fakhri G. Mapping 15O Production Rate for Proton Therapy Verification. International Journal Of Radiation Oncology • Biology • Physics 2015, 92: 453-459. PMID: 25817530, PMCID: PMC4431894, DOI: 10.1016/j.ijrobp.2015.01.023.Peer-Reviewed Original ResearchConceptsDecay constantProton treatment planningMonte Carlo predictionsProton therapyPhantom materialTreatment deliveryPhantomThigh activityPositron emission tomographyProduction rateDynamic PET measurementsTreatment planningRabbit thigh muscleClearance rateProtonIsotopesChanges due to therapyRadionuclide speciesOxygen-15ConstantDecayImaging targetsMontePositronEffects of perfusion
2014
A Recommendation on How to Analyze In-Room PET for In Vivo Proton Range Verification Using a Distal PET Surface Method
Min C, Zhu X, Grogg K, Fakhri G, Winey B, Paganetti H. A Recommendation on How to Analyze In-Room PET for In Vivo Proton Range Verification Using a Distal PET Surface Method. Technology In Cancer Research & Treatment 2014, 14: 320-325. PMID: 25246517, PMCID: PMC4898041, DOI: 10.1177/1533034614547457.Peer-Reviewed Original ResearchConceptsIn vivo range verificationIn-room positron emission tomographyRange verificationBeam passageIn vivo proton range verificationIn-roomIn-room PET scannerPositron emission tomography activityProton beam rangeProton range verificationSingle-field treatmentsProton beam deliveryAverage range differencesBeam rangeBeam deliveryPET scannerRoot-mean-square deviationPositron emission tomographyBeamRange differencesLevel surfaceActive lineActivity levelsLocal variationsTreatment course
2013
Feasibility of Using Distal Endpoints for In-Room PET Range Verification of Proton Therapy
Grogg K, Zhu X, Min C, Winey B, Bortfeld T, Paganetti H, Shih H, Fakhri G. Feasibility of Using Distal Endpoints for In-Room PET Range Verification of Proton Therapy. IEEE Transactions On Nuclear Science 2013, 60: 3290-3297. DOI: 10.1109/tns.2013.2278140.Peer-Reviewed Original ResearchPET distributionsNuclear reactionsProton therapyMC-PETSimulated positron emission tomographyIn-roomMonte CarloPET resolutionPositron emission tomographyRange verificationBiological washoutDose depthThreshold energyDose deliveryCross sectionPlanned doseMC simulationsIndividual beamsSimPETOne-dimensional profilesRadiological decayBeamDistal endpointsProtonNative nucleiFeasibility of using distal endpoints for In-room PET Range Verification of Proton Therapy
Grogg K, Zhu X, Min C, Winey B, Bortfeld T, Paganetti H, Shih H, El Fakhri G. Feasibility of using distal endpoints for In-room PET Range Verification of Proton Therapy. IEEE Transactions On Nuclear Science 2013, 60: 3890-3894. PMID: 24464031, PMCID: PMC3900284, DOI: 10.1109/nssmic.2012.6551892.Peer-Reviewed Original ResearchPET distributionsNuclear reactionsProton therapyMC-PETSimulated positron emission tomographyMonte CarloPET resolutionPositron emission tomographyRange verificationBiological washoutDose depthThreshold energyDose deliveryCross sectionPlanned doseMC simulationsIndividual beamsSimPETOne-dimensional profilesIn-roomRadiological decayBeamDistal endpointsProtonNative nucleiClinical Application of In-Room Positron Emission Tomography for In Vivo Treatment Monitoring in Proton Radiation Therapy
Min C, Zhu X, Winey B, Grogg K, Testa M, Fakhri G, Bortfeld T, Paganetti H, Shih H. Clinical Application of In-Room Positron Emission Tomography for In Vivo Treatment Monitoring in Proton Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2013, 86: 183-189. PMID: 23391817, PMCID: PMC3640852, DOI: 10.1016/j.ijrobp.2012.12.010.Peer-Reviewed Original ResearchConceptsIn-room positron emission tomographyProton therapyIn-roomPositron emission tomography scanIn-room PET scannerPassive scattering proton therapyShapes of target volumesPositron emission tomographyMC predictionBeam range uncertaintiesMeasured PET imagesMonte CarloProton radiation therapyLocal elemental compositionBiological washoutScan timeTreatment headTreatment verificationRange uncertaintiesTarget volumePET scan timePET scannerPET systemComputed tomographyMC results