2018
PRS-on-Spark (PRSoS): a novel, efficient and flexible approach for generating polygenic risk scores
Chen LM, Yao N, Garg E, Zhu Y, Nguyen TTT, Pokhvisneva I, Hari Dass SA, Unternaehrer E, Gaudreau H, Forest M, McEwen LM, MacIsaac JL, Kobor MS, Greenwood CMT, Silveira PP, Meaney MJ, O’Donnell K. PRS-on-Spark (PRSoS): a novel, efficient and flexible approach for generating polygenic risk scores. BMC Bioinformatics 2018, 19: 295. PMID: 30089455, PMCID: PMC6083617, DOI: 10.1186/s12859-018-2289-9.Peer-Reviewed Original Research
2015
funtooNorm: an R package for normalization of DNA methylation data when there are multiple cell or tissue types
Oros Klein K, Grinek S, Bernatsky S, Bouchard L, Ciampi A, Colmegna I, Fortin JP, Gao L, Hivert MF, Hudson M, Kobor MS, Labbe A, MacIsaac JL, Meaney MJ, Morin AM, O'Donnell KJ, Pastinen T, Van Ijzendoorn MH, Voisin G, Greenwood CM. funtooNorm: an R package for normalization of DNA methylation data when there are multiple cell or tissue types. Bioinformatics 2015, 32: 593-595. PMID: 26500152, PMCID: PMC4743629, DOI: 10.1093/bioinformatics/btv615.Peer-Reviewed Original ResearchConceptsMethylation patternsIllumina Infinium Human Methylation450 BeadChipDNA methylation patternsBenefits of cellsDNA methylation dataTissue typesR packageInter-tissue variabilityMethylation dataChromosome XCell typesNew R packageNormalization of dataMore cellsCellsMultiple cellsCross-validated errorBeadChipBioconductor