Featured Publications
Accumbal Histamine Signaling Engages Discrete Interneuron Microcircuits.
Manz KM, Brady LJ, Calipari ES, Grueter BA. Accumbal Histamine Signaling Engages Discrete Interneuron Microcircuits. Biological Psychiatry 2021 PMID: 34953589, PMCID: PMC9012818, DOI: 10.1016/j.biopsych.2021.10.004.Peer-Reviewed Original ResearchHistamine H3 Receptor Function Biases Excitatory Gain in the Nucleus Accumbens.
Manz KM, Becker JC, Grueter CA, Grueter BA. Histamine H3 Receptor Function Biases Excitatory Gain in the Nucleus Accumbens. Biological Psychiatry 2021, 89: 588-599. PMID: 33012522, PMCID: PMC7865000, DOI: 10.1016/j.biopsych.2020.07.023.Peer-Reviewed Original ResearchNoradrenergic Signaling Disengages Feedforward Transmission in the Nucleus Accumbens Shell.
Manz KM, Coleman BC, Grueter CA, Shields BC, Tadross MR, Grueter BA. Noradrenergic Signaling Disengages Feedforward Transmission in the Nucleus Accumbens Shell. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2021, 41: 3752-3763. PMID: 33737458, PMCID: PMC8084318, DOI: 10.1523/JNEUROSCI.2420-20.2021.Peer-Reviewed Original Research
2023
SNAP25 differentially contributes to G(i/o)-coupled receptor function at glutamatergic synapses in the nucleus accumbens.
Manz KM, Zepeda JC, Zurawski Z, Hamm HE, Grueter BA. SNAP25 differentially contributes to G(i/o)-coupled receptor function at glutamatergic synapses in the nucleus accumbens. Front Cell Neurosci 2023, 17: 1165261. PMID: 37206665, DOI: 10.3389/fncel.2023.1165261.Peer-Reviewed Original Research
2022
TAAR1 regulates drug-induced reinstatement of cocaine-seeking via negatively modulating CaMKIIα activity in the NAc.
Liu J, Wu R, Seaman R, Manz KM, Johnson B, Vu J, Huang Y, Zhang Y, Robison AJ, Neve R, Grueter BA, Dietz D, Li JX. TAAR1 regulates drug-induced reinstatement of cocaine-seeking via negatively modulating CaMKIIα activity in the NAc. Molecular Psychiatry 2022, 27: 2136-2145. PMID: 35079125, DOI: 10.1038/s41380-022-01448-3.Peer-Reviewed Original ResearchCocaine restricts nucleus accumbens feedforward drive through a monoamine-independent mechanism.
Manz KM, Coleman BC, Jameson AN, Ghose DG, Patel S, Grueter BA. Cocaine restricts nucleus accumbens feedforward drive through a monoamine-independent mechanism. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2022, 47: 652-663. PMID: 34545194, PMCID: PMC8782870, DOI: 10.1038/s41386-021-01167-3.Peer-Reviewed Original Research
2021
Kappa opioid receptor modulation of excitatory drive onto nucleus accumbens fast-spiking interneurons.
Coleman BC, Manz KM, Grueter BA. Kappa opioid receptor modulation of excitatory drive onto nucleus accumbens fast-spiking interneurons. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2021, 46: 2340-2349. PMID: 34400782, PMCID: PMC8581025, DOI: 10.1038/s41386-021-01146-8.Peer-Reviewed Original ResearchPatch-clamp and multi-electrode array electrophysiological analysis in acute mouse brain slices.
Manz KM, Siemann JK, McMahon DG, Grueter BA. Patch-clamp and multi-electrode array electrophysiological analysis in acute mouse brain slices. STAR Protocols 2021, 2: 100442. PMID: 33899023, PMCID: PMC8056272, DOI: 10.1016/j.xpro.2021.100442.Peer-Reviewed Original ResearchCannabinoid type 1 receptors in A2a neurons contribute to cocaine-environment association.
Turner BD, Smith NK, Manz KM, Chang BT, Delpire E, Grueter CA, Grueter BA. Cannabinoid type 1 receptors in A2a neurons contribute to cocaine-environment association. Psychopharmacology 2021, 238: 1121-1131. PMID: 33454843, PMCID: PMC8386588, DOI: 10.1007/s00213-021-05759-1.Peer-Reviewed Original Research
2020
Calcium-Permeable AMPA Receptors Promote Endocannabinoid Signaling at Parvalbumin Interneuron Synapses in the Nucleus Accumbens Core.
Manz KM, Ghose D, Turner BD, Taylor A, Becker J, Grueter CA, Grueter BA. Calcium-Permeable AMPA Receptors Promote Endocannabinoid Signaling at Parvalbumin Interneuron Synapses in the Nucleus Accumbens Core. Cell Reports 2020, 32: 107971. PMID: 32726634, PMCID: PMC7422922, DOI: 10.1016/j.celrep.2020.107971.Peer-Reviewed Original Research
2019
Heterosynaptic GABAB Receptor Function within Feedforward Microcircuits Gates Glutamatergic Transmission in the Nucleus Accumbens Core.
Manz KM, Baxley AG, Zurawski Z, Hamm HE, Grueter BA. Heterosynaptic GABAB Receptor Function within Feedforward Microcircuits Gates Glutamatergic Transmission in the Nucleus Accumbens Core. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2019, 39: 9277-9293. PMID: 31578230, PMCID: PMC6867813, DOI: 10.1523/JNEUROSCI.1395-19.2019.Peer-Reviewed Original Research
2018
Synaptic Plasticity in the Nucleus Accumbens: Lessons Learned from Experience.
Turner BD, Kashima DT, Manz KM, Grueter CA, Grueter BA. Synaptic Plasticity in the Nucleus Accumbens: Lessons Learned from Experience. ACS Chem Neurosci 2018, 9: 2114-2126. PMID: 29280617, DOI: 10.1021/acschemneuro.7b00420.Peer-Reviewed Original ResearchA novel adolescent chronic social defeat model: reverse-Resident-Intruder Paradigm (rRIP) in male rats.
Manz KM, Levine WA, Seckler JC, Iskander AN, Reich CG. A novel adolescent chronic social defeat model: reverse-Resident-Intruder Paradigm (rRIP) in male rats. Stress (Amsterdam, Netherlands) 2018, 21: 169-178. PMID: 29307250, PMCID: PMC6137812, DOI: 10.1080/10253890.2017.1423285.Peer-Reviewed Original Research