2015
DNA methylation in ductal carcinoma in situ related with future development of invasive breast cancer
Johnson K, Koestler D, Fleischer T, Chen P, Jenson E, Marotti J, Onega T, Kristensen V, Christensen B. DNA methylation in ductal carcinoma in situ related with future development of invasive breast cancer. Clinical Epigenetics 2015, 7: 75. PMID: 26213588, PMCID: PMC4514996, DOI: 10.1186/s13148-015-0094-0.Peer-Reviewed Original ResearchInvasive breast cancerAdjacent normal tissuesInvasive diseaseBreast cancerDuctal carcinomaEstrogen receptor-positive DCISEarly-stage breast cancerAccurate risk stratificationAge-matched subjectsStage breast cancerInvasive ductal carcinomaCancer Genome Atlas (TCGA) databasePre-invasive lesionsAppropriate treatment decisionsIllumina HumanMethylation450K arrayBackgroundDuctal carcinomaPositive DCISInvasive recurrenceDCIS progressionDCIS casesProgression of cancerRisk stratificationDisease progressionTreatment decisionsClinical challenge
2014
Genome-wide DNA methylation profiles in progression to in situand invasive carcinoma of the breast with impact on gene transcription and prognosis
Fleischer T, Frigessi A, Johnson K, Edvardsen H, Touleimat N, Klajic J, Riis M, Haakensen V, Wärnberg F, Naume B, Helland Å, Børresen-Dale A, Tost J, Christensen B, Kristensen V. Genome-wide DNA methylation profiles in progression to in situand invasive carcinoma of the breast with impact on gene transcription and prognosis. Genome Biology 2014, 15: 435. PMID: 25146004, PMCID: PMC4165906, DOI: 10.1186/s13059-014-0435-x.Peer-Reviewed Original ResearchConceptsGenome-wide DNA methylation profilesDNA methylation profilesMethylation profilesInvasive breast carcinomaProgression of cancerBreast carcinomaDNA methylation alterationsPrognostic signatureDNA methylation-based markersCancer Genome AtlasDNA methylationGene transcriptionMethylation changesMethylation-based markersEpigenetic changesMethylation alterationsSurvival of patientsGene expressionBreast cancer patientsMethylation levelsNormal breast tissueBreast cancer samplesClinical decision makingGenesGenome Atlas