2023
Centralspindlin proteins Pavarotti and Tumbleweed along with WASH regulate nuclear envelope budding
Davidson K, Nakamura M, Verboon J, Parkhurst S. Centralspindlin proteins Pavarotti and Tumbleweed along with WASH regulate nuclear envelope budding. Journal Of Cell Biology 2023, 222: e202211074. PMID: 37163553, PMCID: PMC10174194, DOI: 10.1083/jcb.202211074.Peer-Reviewed Original ResearchConceptsNuclear envelope buddingActin nucleation activityNuclear export pathwayNE buddingExport pathwayWiskott-Aldrich syndrome proteinProtein quality controlActin-bundling activityNew molecular componentsCargo recruitmentSyndrome proteinRegulatory complexMitochondrial integritySynapse developmentCell differentiationStructural roleMolecular componentsNuclear washesLarge cargoBuddingPavarottiBudsMachineryTumbleweedNew entry point
2020
Drosophila Wash and the Wash regulatory complex function in nuclear envelope budding
Verboon JM, Nakamura M, Davidson KA, Decker JR, Nandakumar V, Parkhurst SM. Drosophila Wash and the Wash regulatory complex function in nuclear envelope budding. Journal Of Cell Science 2020, 133: jcs243576. PMID: 32503943, PMCID: PMC7358131, DOI: 10.1242/jcs.243576.Peer-Reviewed Original ResearchConceptsNuclear envelope buddingBud formationImportant cellular processesNew molecular componentsNuclear lamina disruptionLarge macromolecular complexesDrosophila WashNE buddingRegulatory complexMolecular machineryCellular processesLamin BMacromolecular complexesCellular eventsNuclear membraneEgress mechanismsMolecular componentsArp2/3BuddingLamina disruptionDisease biologyModel systemProteinComplex functionsNew avenues