1993
Genomic and Yeast Artificial Chromosome Long-Range Regular Article Linking Six Loci in 10q11.2 and Spanning the Multiple Endocrine Neoplasia Type 2A (MEN2A) Region
Brooks-Wilson A, Lichter J, Ward D, Kidd K, Goodfellow P. Genomic and Yeast Artificial Chromosome Long-Range Regular Article Linking Six Loci in 10q11.2 and Spanning the Multiple Endocrine Neoplasia Type 2A (MEN2A) Region. Genomics 1993, 17: 611-617. PMID: 7902324, DOI: 10.1006/geno.1993.1380.Peer-Reviewed Original ResearchConceptsRestriction mappingIdentification of genesLong-range restriction mappingContig assemblyPhysical mapTumor-specific alterationsGenomic DNAYAC contigPhysical linkageCandidate intervalDistal lociLociProto-oncogeneD10S102GenesCandidate regionsRET proto-oncogeneFamilial medullary thyroid carcinomaType 2ARETD10S94Multiple endocrine neoplasia type 2AContigsGenomicsHereditary cancerA new polymorphic marker (D10S97) tightly linked to the multiple endocrine neoplasia type 2A (MEN2A) locus
Lichter J, Wu J, Brooks-Wilson A, Difillipantonio M, Brewster S, Ward D, Goodfellow P, Kidd K. A new polymorphic marker (D10S97) tightly linked to the multiple endocrine neoplasia type 2A (MEN2A) locus. Human Genetics 1993, 90: 516-520. PMID: 8094065, DOI: 10.1007/bf00217451.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceChromosome MappingChromosomes, FungalChromosomes, Human, Pair 10Cloning, MolecularCricetinaeDeoxyribonuclease EcoRIDNADNA ProbesFemaleGene FrequencyGene LibraryGenetic LinkageGenetic MarkersGenome, HumanHumansHybrid CellsIn Situ Hybridization, FluorescenceLod ScoreMaleMolecular Sequence DataMultiple Endocrine NeoplasiaPedigreePolymorphism, GeneticPolymorphism, Restriction Fragment LengthSequence Analysis, DNAConceptsMultiple endocrine neoplasia type 2AType 2AClinical featuresMedullary carcinomaCancer syndromesAutosomal dominantHigh penetranceEcoRI polymorphismMEN2A
1990
Search for the Gene for Multiple Endocrine Neoplasia Type 2A
KIDD K, SIMPSON N. Search for the Gene for Multiple Endocrine Neoplasia Type 2A. 1990, 46: 305-343. PMID: 2281187, DOI: 10.1016/b978-0-12-571146-3.50015-8.Peer-Reviewed Original ResearchConceptsMultiple endocrine neoplasia type 2AType 2AElevated hormone levelsHereditary cancer syndromesMultiple endocrine glandsSlow growingAbnormal alleleMedullary carcinomaAssociated mortalityParathyroid glandsHormone levelsUnique tissue distributionSerious symptomsTissue massCancer syndromesEndocrine glandsVital organsClinical useRisk estimatesTumorsTissue distributionC cellsElevated productionAdditional markersThyroid
1989
The mapping of the locus for multiple endocrine neoplasia type 2A by linkage with chromosome 10 markers.
Simpson N, Kidd K. The mapping of the locus for multiple endocrine neoplasia type 2A by linkage with chromosome 10 markers. Hormone And Metabolic Research. Supplement Series 1989, 21: 5-9. PMID: 2572529.Peer-Reviewed Original ResearchConceptsDisease locusInterstitial retinol-binding proteinChromosome 10 markersTest of linkageChromosome 10Disease genesDeletion siteChromosome 20Additional family dataBinding proteinLociGenesExclusion of linkageSitu hybridizationD10S5Ultimate identificationRetinol-binding proteinType 2AMultiple endocrine neoplasia type 2AGenomeMarkersFamily dataLinkageProteinHybridization
1988
A linkage group of five DNA markers on human chromosome 10
Farrer L, Castiglione C, Kidd J, Myers S, Carson N, Simpson N, Kidd K. A linkage group of five DNA markers on human chromosome 10. Genomics 1988, 3: 72-77. PMID: 2906045, DOI: 10.1016/0888-7543(88)90162-0.Peer-Reviewed Original ResearchConceptsLinkage groupsDNA markersChromosome 10Recombination frequencySex-specific recombination frequenciesAccurate genetic mapHuman chromosome 10Three-locus analysisLong armChromosome 10 markersGenetic mapLinkage mapPericentric regionsMarker lociMap intervalPrevious localizationLinkage analysisProximal regionLociLarge pedigreeType 2APedigreeMultiple endocrine neoplasia type 2AD10S5Markers
1987
An efficient strategy for gene mapping using multipoint linkage analysis: exclusion of the multiple endocrine neoplasia 2A (MEN2A) locus from chromosome 13.
Farrer L, Goodfellow P, Lamarche C, Franjkovic I, Myers S, White B, Holden J, Kidd J, Simpson N, Kidd K. An efficient strategy for gene mapping using multipoint linkage analysis: exclusion of the multiple endocrine neoplasia 2A (MEN2A) locus from chromosome 13. American Journal Of Human Genetics 1987, 40: 329-37. PMID: 2883889, PMCID: PMC1684085.Peer-Reviewed Original ResearchConceptsMarker lociGenetic mapChromosome 13Red cell enzyme markersMapping disease genesLarger genetic mapMultipoint analysisLinkage mapMultipoint linkage analysisGene mappingDNA markersDisease genesTwo-point analysisLinkage analysisLociMEN2A locusClose linkageEnzyme markersType 2AMultiple endocrine neoplasia type 2ACMorganGenesMarkersMultiple endocrine neoplasia 2AFamilyOne large kindred excludes a locus for multiple endocrine neoplasia type 2A from about 25% of the human autosomal genetic map.
Pakstis A, Kidd J, Castiglione C, Pletcher B, Murphy P, Farrer L, Genel M, Kidd K. One large kindred excludes a locus for multiple endocrine neoplasia type 2A from about 25% of the human autosomal genetic map. Henry Ford Hospital Medical Journal 1987, 35: 164-7. PMID: 2891651.Peer-Reviewed Original Research
1986
Linkage Analyses of Multiple Endocrine Neoplasia, Type 2A (MEN-2A) with 20 DNA Polymorphisms: 5% of the Genome Excluded
Kidd K, Kidd J, Castiglione C, Genel M, Darby J, Cavalli-Sforza L, Gusella J. Linkage Analyses of Multiple Endocrine Neoplasia, Type 2A (MEN-2A) with 20 DNA Polymorphisms: 5% of the Genome Excluded. Human Heredity 1986, 36: 243-249. PMID: 2875939, DOI: 10.1159/000153634.Peer-Reviewed Original Research