2024
Anxiety and depression are associated with heightened risk of incident deep vein thrombosis: Mediation through stress‐related neural mechanisms
Rosovsky R, Mezue K, Gharios C, Civieri G, Cardeiro A, Zureigat H, Lau H, Pitman R, Shin L, Abohashem S, Osborne M, Jaffer F, Tawakol A. Anxiety and depression are associated with heightened risk of incident deep vein thrombosis: Mediation through stress‐related neural mechanisms. American Journal Of Hematology 2024, 99: 1927-1938. PMID: 38965839, PMCID: PMC11502251, DOI: 10.1002/ajh.27427.Peer-Reviewed Original ResearchTreatment of anxietyAssociated with heightened riskDeep vein thrombosisNeural mechanismsHeart rate variabilityAutonomic system activityMediation analysisVein thrombosisHs-CRPNeural activityAnxietyDepressionCortical activityIncident deep vein thrombosisF-FDG PET/CT imagingHigh-sensitivity C-reactive proteinFemale participantsMedian follow-upC-reactive proteinDVT risk factorsMedian ageMass General Brigham BiobankRetrospective studyChronic inflammationFollow-up
2022
Genetic sensitivity to stress modifies the relationship between socioeconomic status and major adverse cardiovascular events
Abohashem S, Osborne M, Choi K, Liu Z, Zureigat H, Mezue K, Gharios C, Armstrong K, Smoller J, Tawakol A. Genetic sensitivity to stress modifies the relationship between socioeconomic status and major adverse cardiovascular events. European Heart Journal 2022, 43: ehac544.2265. DOI: 10.1093/eurheartj/ehac544.2265.Peer-Reviewed Original ResearchLow socioeconomic statusArea Deprivation IndexSocioeconomic statusMajor adverse cardiovascular eventsRisk associated with low socioeconomic statusCardiovascular diseaseMass General Brigham BiobankPolygenic risk scoresYears of follow-upAssociation with incident major adverse cardiovascular eventsIncident major adverse cardiovascular eventsDeprivation indexHome addressAssociated with major adverse cardiovascular eventsMedian incomeRisk scoreRisk factorsMediation analysisAdverse cardiovascular eventsNeural pathwaysFunding sourcesFollow-upCardiovascular eventsStress sensitivityIndividuals
2021
Moderate alcohol intake associates with a decreased risk of venous thrombosis: mediation through decreased stress-associated brain activity
Mezue K, Osborne M, Abbasi T, Zureigat H, Abohashem S, Gharios C, Akuffo E, Cardeiro A, Pitman R, Shin L, Jaffer F, Rosovsky R, Tawakol A. Moderate alcohol intake associates with a decreased risk of venous thrombosis: mediation through decreased stress-associated brain activity. European Heart Journal 2021, 42: ehab724.2046. DOI: 10.1093/eurheartj/ehab724.2046.Peer-Reviewed Original ResearchModerate alcohol intakeDeep venous thrombosisAlcohol intakeNeural activityEffects of alcoholEffects of moderate alcoholVenous thrombosisDecreased riskNeural effectsMedian follow-up periodDeep venous thrombosis riskBrain activityMediation analysisRisk of deep venous thrombosisIncidence of deep venous thrombosisRisk of venous thrombosisDecreased risk of venous thrombosisAdult participantsEmission tomography imagingCox regression analysisFollow-up periodNeural pathwaysNeurobiological activityFollow-up outcome informationModerate alcoholAnxiety and depression associate with heightened risk of deep venous thrombosis: mediation through neural pathways
Mezue K, Osborne M, Abohashem S, Zureigat H, Abbasi T, Gharios C, Cardeiro A, Akuffo E, Pitman R, Shin L, Jaffer F, Rosovsky R, Tawakol A. Anxiety and depression associate with heightened risk of deep venous thrombosis: mediation through neural pathways. European Heart Journal 2021, 42: ehab724.2045. DOI: 10.1093/eurheartj/ehab724.2045.Peer-Reviewed Original ResearchAnxiety disordersInternational Classification of DiseasesRisk of deep venous thrombosisDeep venous thrombosisNeural activityNeural pathwaysFollow-up periodMass General Brigham BiobankIncreased riskClassification of DiseasesBiobank enrollmentVenous thrombosisIncreased risk of DVTCancer historyIncreased risk of deep venous thrombosisHealth informationMediation analysisDeep venous thrombosis riskInternational ClassificationMedian follow-up periodPotential confoundersAnxietyLower extremity deep venous thrombosisExtremity deep venous thrombosisDepression