2021
The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2
Zhang S, Zhou J, Zhang Y, Liu T, Friedel P, Zhuo W, Somasekharan S, Roy K, Zhang L, Liu Y, Meng X, Deng H, Zeng W, Li G, Forbush B, Yang M. The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2. Communications Biology 2021, 4: 226. PMID: 33597714, PMCID: PMC7889885, DOI: 10.1038/s42003-021-01750-w.Peer-Reviewed Original ResearchConceptsCryo-electron microscopy structureHuman NKCC1Microscopy structureEssential residuesFunctional characterizationKCC transportersPlasma membraneStructural basisTransepithelial saltTransport activityMechanistic understandingTransportersStructural studiesCritical roleCotransporter NKCC1Computational analysisIon transportWater transportNeuronal excitabilityNKCC1PhosphorylationCell volumeNKCCKCC2Residues
2014
Interaction of Grb2 SH3 domain with UVRAG in an Alzheimer’s disease–like scenario
Roy K, Chakrabarti O, Mukhopadhyay D. Interaction of Grb2 SH3 domain with UVRAG in an Alzheimer’s disease–like scenario. Biochemistry And Cell Biology 2014, 92: 219-225. PMID: 24882360, DOI: 10.1139/bcb-2014-0001.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseGRB2 Adaptor ProteinHumansProtein BindingSrc Homology DomainsTumor Cells, CulturedTumor Suppressor ProteinsConceptsSrc homology 3SH3 domainGrowth factor receptor-bound protein 2Receptor-bound protein 2C-terminal SH3 domainIntracellular domain interactionsN-terminal SH3 domainRole of Grb2Autophagic maturationHomology 3Actin remodelingAdaptor proteinCellular compartmentalizationGrb2Cell line modelsDomain interactionsGene proteinProtein 2ProteinAutophagosomesExcess conditionsVesiclesDomainCompartmentalizationMotif