2016
The microRNA miR-148a functions as a critical regulator of B cell tolerance and autoimmunity
Gonzalez-Martin A, Adams BD, Lai M, Shepherd J, Salvador-Bernaldez M, Salvador JM, Lu J, Nemazee D, Xiao C. The microRNA miR-148a functions as a critical regulator of B cell tolerance and autoimmunity. Nature Immunology 2016, 17: 433-440. PMID: 26901150, PMCID: PMC4803625, DOI: 10.1038/ni.3385.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisApoptosis Regulatory ProteinsAutoimmunityB-LymphocytesBcl-2-Like Protein 11Bone Marrow TransplantationCell Cycle ProteinsCell ProliferationDisease Models, AnimalHEK293 CellsHumansImmune ToleranceImmunoblottingLupus Erythematosus, SystemicMembrane ProteinsMiceMice, Inbred MRL lprMicroRNAsNuclear ProteinsProto-Oncogene ProteinsPTEN PhosphohydrolaseReverse Transcriptase Polymerase Chain ReactionSequence Analysis, RNA
2013
C/EBPα poises B cells for rapid reprogramming into induced pluripotent stem cells
Di Stefano B, Sardina JL, van Oevelen C, Collombet S, Kallin EM, Vicent GP, Lu J, Thieffry D, Beato M, Graf T. C/EBPα poises B cells for rapid reprogramming into induced pluripotent stem cells. Nature 2013, 506: 235-239. PMID: 24336202, DOI: 10.1038/nature12885.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesCCAAT-Enhancer-Binding Protein-alphaCell TransdifferentiationCells, CulturedCellular ReprogrammingChromatinCytosineDeoxyribonuclease IDioxygenasesDNA MethylationDNA-Binding ProteinsEpithelial-Mesenchymal TransitionInduced Pluripotent Stem CellsKruppel-Like Factor 4Kruppel-Like Transcription FactorsMiceOctamer Transcription Factor-3Proto-Oncogene ProteinsProto-Oncogene Proteins c-mycSOXB1 Transcription FactorsUp-RegulationConceptsInduced pluripotent stem cellsPluripotent stem cellsTranscription factors Oct4Stem cellsTET2 enzymeChromatin accessibilityPluripotency genesRapid reprogrammingEfficient reprogrammingFactors OCT4B cell precursorsReprogrammingCell precursorsCellsB cellsGenesKLF4MYCSOX2OverexpressionEnzymeExpressionActivation
2011
MicroRNA Expression Profiling Identifies Activated B Cell Status in Chronic Lymphocytic Leukemia Cells
Li S, Moffett HF, Lu J, Werner L, Zhang H, Ritz J, Neuberg D, Wucherpfennig KW, Brown JR, Novina CD. MicroRNA Expression Profiling Identifies Activated B Cell Status in Chronic Lymphocytic Leukemia Cells. PLOS ONE 2011, 6: e16956. PMID: 21408091, PMCID: PMC3050979, DOI: 10.1371/journal.pone.0016956.Peer-Reviewed Original ResearchConceptsB cell statusChronic lymphocytic leukemiaCLL cellsB cellsCpG activationChronic lymphocytic leukemia cellsActivated B cellsLymphocytic leukemia cellsCell statusClinical courseFirst therapyExpression profiling identifiesLymphocytic leukemiaNormal donorsUnmutated statusMiR-155MiR-223MiR-181bMiR-29cMiR-181aLeukemia cellsMiR-103Untransformed B cellsRecent dataProfiling identifies