2023
Multicenter study of the natural history and therapeutic responses of patients with chikungunya, focusing on acute and chronic musculoskeletal manifestations – a study protocol from the clinical and applied research in Chikungunya (REPLICK network)
da Silva Duarte G, Jones A, de Goes Cavalcanti L, de Melo Rêgo M, Ribeiro G, Boyton R, Pereira D, Croda J, Costa F, Duarte A, Consolaro M, Stabeli R, Negrão F, Proenca-Modena J, Villalobos-Salcedo J, da Rocha Castelar Pinheiro G, de Barros Albuquerque A, de Almeida Barreto F, Moreira J, Ferrari I, Évora P, da Silva V, Lacerda M, Altmann D, Siqueira A. Multicenter study of the natural history and therapeutic responses of patients with chikungunya, focusing on acute and chronic musculoskeletal manifestations – a study protocol from the clinical and applied research in Chikungunya (REPLICK network). BMC Infectious Diseases 2023, 23: 499. PMID: 37507666, PMCID: PMC10386654, DOI: 10.1186/s12879-023-08292-y.Peer-Reviewed Original ResearchMeSH KeywordsChikungunya FeverChronic DiseaseCohort StudiesHumansMulticenter Studies as TopicProspective StudiesQuality of LifeConceptsMusculoskeletal manifestationsStudy protocolTherapeutic responseChronic diseasesNatural historyDestructive disease courseMulticenter cohort studyLong-term sequelaeAssociated risk factorsClinical report formsClinical trial designQuality of lifeAliquots of bloodCohort studyCHIKV infectionDisease courseChronic painSymptomatic infectionBlood testsHigh morbidityMulticenter studyMusculoskeletal symptomsTherapeutic guidelinesClinical spectrumPatient cohort
2019
Return of the founder Chikungunya virus to its place of introduction into Brazil is revealed by genomic characterization of exanthematic disease cases
Maia Z, Pereira F, do Carmo Said R, Fonseca V, Gräf T, de Bruycker Nogueira F, Nardy V, Xavier J, Maia M, Abreu A, de Albuquerque C, Oliveira W, Croda J, de Filippis A, Cunha R, Lourenço J, de Oliveira T, Faria N, Alcantara L, Giovanetti M. Return of the founder Chikungunya virus to its place of introduction into Brazil is revealed by genomic characterization of exanthematic disease cases. Emerging Microbes & Infections 2019, 9: 53-57. PMID: 31880218, PMCID: PMC6968431, DOI: 10.1080/22221751.2019.1701954.Peer-Reviewed Original ResearchConceptsNumber of patientsGenomic surveillance strategiesFebrile illnessArboviral infectionsEpidemic seasonChikungunya virusWhole-genome sequencingDisease casesSurveillance strategiesGenetic diversityEpidemiological analysisMolecular clockCHIKV ECSA genotypeTransmission potentialGenome sequencingArboviral transmissionGenomic characterizationCHIKVLocal persistence
2017
Seroprevalence of Chikungunya Virus in a Rural Community in Brazil
Cunha R, Trinta K, Montalbano C, Sucupira M, de Lima M, Marques E, Romanholi I, Croda J. Seroprevalence of Chikungunya Virus in a Rural Community in Brazil. PLOS Neglected Tropical Diseases 2017, 11: e0005319. PMID: 28107342, PMCID: PMC5287455, DOI: 10.1371/journal.pntd.0005319.Peer-Reviewed Original ResearchConceptsCases of chikungunyaCHIKV infectionChikungunya virusCHIKV IgMSymptomatic CHIKV infectionIgM-specific antibodiesFeira de SantanaIgG-specific antibodiesEpidemiological surveillance systemBrazilian Epidemiological Surveillance SystemCHIKV IgGModerate seroprevalenceSeropositive patientsJoint painIgG antibodiesCHIKV transmissionFirst serosurveySeroprevalenceInfectionMagnitude of transmissionAntibodiesPatientsFirst caseSerosurveyIgM