2023
Multicenter study of the natural history and therapeutic responses of patients with chikungunya, focusing on acute and chronic musculoskeletal manifestations – a study protocol from the clinical and applied research in Chikungunya (REPLICK network)
da Silva Duarte G, Jones A, de Goes Cavalcanti L, de Melo Rêgo M, Ribeiro G, Boyton R, Pereira D, Croda J, Costa F, Duarte A, Consolaro M, Stabeli R, Negrão F, Proenca-Modena J, Villalobos-Salcedo J, da Rocha Castelar Pinheiro G, de Barros Albuquerque A, de Almeida Barreto F, Moreira J, Ferrari I, Évora P, da Silva V, Lacerda M, Altmann D, Siqueira A. Multicenter study of the natural history and therapeutic responses of patients with chikungunya, focusing on acute and chronic musculoskeletal manifestations – a study protocol from the clinical and applied research in Chikungunya (REPLICK network). BMC Infectious Diseases 2023, 23: 499. PMID: 37507666, PMCID: PMC10386654, DOI: 10.1186/s12879-023-08292-y.Peer-Reviewed Original ResearchMeSH KeywordsChikungunya FeverChronic DiseaseCohort StudiesHumansMulticenter Studies as TopicProspective StudiesQuality of LifeConceptsMusculoskeletal manifestationsStudy protocolTherapeutic responseChronic diseasesNatural historyDestructive disease courseMulticenter cohort studyLong-term sequelaeAssociated risk factorsClinical report formsClinical trial designQuality of lifeAliquots of bloodCohort studyCHIKV infectionDisease courseChronic painSymptomatic infectionBlood testsHigh morbidityMulticenter studyMusculoskeletal symptomsTherapeutic guidelinesClinical spectrumPatient cohort
2021
A Rapid Pharmacogenomic Assay to Detect NAT2 Polymorphisms and Guide Isoniazid Dosing for Tuberculosis Treatment.
Verma R, Patil S, Zhang N, Moreira F, Vitorio M, Santos A, Wallace E, Gnanashanmugam D, Persing D, Savic R, Croda J, Andrews J. A Rapid Pharmacogenomic Assay to Detect NAT2 Polymorphisms and Guide Isoniazid Dosing for Tuberculosis Treatment. American Journal Of Respiratory And Critical Care Medicine 2021, 204: 1317-1326. PMID: 34375564, DOI: 10.1164/rccm.202103-0564oc.Peer-Reviewed Original ResearchConceptsPharmacogenomic assaysSparse pharmacokinetic samplingInadequate treatment responseInterindividual pharmacokinetic variabilityAcetylation genotypeIsoniazid clearancePharmacokinetic samplingPulmonary tuberculosisWhole blood samplesIntermediate acetylatorsPharmacokinetic variabilityFast acetylatorsNAT2 polymorphismsAcetylator typeSlow acetylatorsTuberculosis treatmentTreatment responseBlood samplesGeneXpert platformTuberculosis diagnosisVariable drug concentrationsHealthy individualsPersonalized dosingSubstantial incidenceStandardized dosing
2020
Prevalence, incidence and associated factors for HBV infection among male and female prisoners in Central Brazil: A multicenter study
Rezende G, Lago B, Puga M, Bandeira L, Pompilio M, Castro V, Tanaka T, Cesar G, Oliveira S, Yassuda R, Simionatto S, Weis S, Basílio S, Croda J, Motta-Castro A. Prevalence, incidence and associated factors for HBV infection among male and female prisoners in Central Brazil: A multicenter study. International Journal Of Infectious Diseases 2020, 96: 298-307. PMID: 32315810, DOI: 10.1016/j.ijid.2020.04.019.Peer-Reviewed Original ResearchConceptsHBV exposureHepatitis B virus infectionHCV/HBVIncidence of HBVHBV serological markersB virus infectionCross-sectional studyGenotypes/subtypesHBV infectionCohort studySerological markersHBV isolatesMulticenter studyHigh prevalenceLower incidenceVirus infectionHigh riskHBVNew casesBlood collectionFemale prisonersInfectionIncidencePreventive measuresPrevalence
2018
Assessment of Validity of a Blood-Based 3-Gene Signature Score for Progression and Diagnosis of Tuberculosis, Disease Severity, and Treatment Response
Warsinske H, Rao A, Moreira F, Santos P, Liu A, Scott M, Malherbe S, Ronacher K, Walzl G, Winter J, Sweeney T, Croda J, Andrews J, Khatri P. Assessment of Validity of a Blood-Based 3-Gene Signature Score for Progression and Diagnosis of Tuberculosis, Disease Severity, and Treatment Response. JAMA Network Open 2018, 1: e183779. PMID: 30646264, PMCID: PMC6324428, DOI: 10.1001/jamanetworkopen.2018.3779.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntitubercular AgentsBrazilChildCohort StudiesDisease ProgressionFemaleGenes, BacterialGenetic MarkersHumansLatent TuberculosisMaleMiddle AgedMolecular TypingMycobacterium tuberculosisReal-Time Polymerase Chain ReactionReproducibility of ResultsRNA, BacterialSeverity of Illness IndexTuberculosisYoung AdultConceptsTB scoreAdolescent cohort studyNegative predictive valueTreatment responseTB diseaseCohort studyTuberculosis infectionTriage testPositron emission tomography-computed tomography scanPredictive valueLatent M tuberculosis infectionLatent Mycobacterium tuberculosis infectionPrimary health care clinicsHigh negative predictive valueCulture-positive adultsM tuberculosis infectionWhole bloodMycobacterium tuberculosis infectionEnd of treatmentHealth care clinicsCase-control studyIndependent prospective cohortsDiagnosis of tuberculosisSlower treatment responseCase-control cohortTreatment Outcomes of Brazilian Inmates with Treponema pallidum and Human Immunodeficiency Virus Infection: A Prospective Cohort Study.
Bet G, Souza G, Croda J, Correa M, de Sales R, Santos R, Viebrantz Enne Sgarbi R, Yassuda R, Coimbra Motta-Castro A, Pompílio M, Simionatto S. Treatment Outcomes of Brazilian Inmates with Treponema pallidum and Human Immunodeficiency Virus Infection: A Prospective Cohort Study. American Journal Of Tropical Medicine And Hygiene 2018, 98: 1603-1608. PMID: 29737273, PMCID: PMC6086195, DOI: 10.4269/ajtmh.17-0592.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusHIV-1 viral loadProspective cohort studyPoor treatment outcomesTreatment outcomesCohort studyHIV infectionViral loadHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionCopies/mLMedical record dataPublic health programsSyphilis treatmentImmunodeficiency virusAcquired syphilisRisk factorsSerological testingVirus infectionBlood samplesMultivariate analysisHealth programsNew casesInfectionTreponema pallidum
2017
Prevalence and Incidence of HCV Infection among Prisoners in Central Brazil
Puga M, Bandeira L, Pompilio M, Croda J, de Rezende G, Dorisbor L, Tanaka T, Cesar G, Teles S, Simionatto S, Novais A, Nepomuceno B, Castro L, do Lago B, Motta-Castro A. Prevalence and Incidence of HCV Infection among Prisoners in Central Brazil. PLOS ONE 2017, 12: e0169195. PMID: 28060860, PMCID: PMC5218405, DOI: 10.1371/journal.pone.0169195.Peer-Reviewed Original ResearchConceptsHCV infectionCohort studyHCV RNASectional studyInjecting-drug useNew HCV infectionsHCV risk behaviorsCross-sectional studyHCV exposureHepatitis CHIV positivityEffective intervention strategiesAssociated FactorsClinical evaluationIndependent associationOverall prevalenceRisk factorsIncidence rateBlood samplesDrug useNew casesRisk behaviorsInfectionHigh frequency ratePrevalence
2016
Impact of mass-screening on tuberculosis incidence in a prospective cohort of Brazilian prisoners
Paião DS, Lemos EF, Carbone AD, Sgarbi RV, Junior AL, da Silva FM, Brandão LM, dos Santos LS, Martins VS, Simionatto S, Motta-Castro AR, Pompílio MA, Urrego J, Ko AI, Andrews JR, Croda J. Impact of mass-screening on tuberculosis incidence in a prospective cohort of Brazilian prisoners. BMC Infectious Diseases 2016, 16: 533. PMID: 27716170, PMCID: PMC5048439, DOI: 10.1186/s12879-016-1868-5.Peer-Reviewed Original ResearchConceptsTuberculin skin testingActive tuberculosisRisk factorsSubsequent diseaseProspective cohort studyEarly case detectionHigh transmission settingsHigh-risk populationPotential risk factorsProportional hazards modelSubsequent disease riskMass screening interventionTST conversionCohort studyProspective cohortHIV testingTuberculosis infectionScreening interventionsSkin testingTB notificationsTuberculosis incidenceSubsequent riskCase detectionSputum samplesActive screening
2015
Risk Factors for Death from Visceral Leishmaniasis in an Urban Area of Brazil
Druzian A, de Souza A, de Campos D, Croda J, Higa M, Dorval M, Pompilio M, de Oliveira P, Paniago A. Risk Factors for Death from Visceral Leishmaniasis in an Urban Area of Brazil. PLOS Neglected Tropical Diseases 2015, 9: e0003982. PMID: 26274916, PMCID: PMC4537269, DOI: 10.1371/journal.pntd.0003982.Peer-Reviewed Original ResearchConceptsHIV/AIDSVisceral leishmaniasisRisk factorsAdult patientsMortality rateUrban endemic areaProspective cohort studySecondary bacterial infectionHigh mortality rateEndemic urban areaCohort studyEpidemiological profileMean ageUniversity HospitalEndemic areasMultivariate analysisPatientsBacterial infectionsAIDSDeathSignificant increaseHigh rateLeishmaniasisEdemaRelapse
2012
Tuberculosis control in a highly endemic indigenous community in Brazil
Croda M, Trajber Z, da Costa Lima R, Croda J. Tuberculosis control in a highly endemic indigenous community in Brazil. Transactions Of The Royal Society Of Tropical Medicine And Hygiene 2012, 106: 223-229. PMID: 22365154, DOI: 10.1016/j.trstmh.2012.01.005.Peer-Reviewed Original ResearchConceptsTB treatmentNon-Indigenous populationsTB patientsTB case fatality rateImplementation of DOTSRetrospective cohort studyCase fatality rateNumber of patientsHIV-positive statusTimes higher mortalityHigh rateCohort studyTB controlCase fatalityDOTS implementationHIV prevalenceTuberculosis controlFatality rateHigh mortalityMultivariate analysisPatientsYoung adultsMortalityPriority groupsIndigenous populations
2009
Benefit of antiretroviral therapy on survival of human immunodeficiency virus-infected patients admitted to an intensive care unit
Croda J, Croda M, Neves A, dos Santos S. Benefit of antiretroviral therapy on survival of human immunodeficiency virus-infected patients admitted to an intensive care unit. Critical Care Medicine 2009, 37: 1605-1611. PMID: 19325488, PMCID: PMC4143892, DOI: 10.1097/ccm.0b013e31819da8c7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Retroviral AgentsAntiretroviral Therapy, Highly ActiveBrazilCohort StudiesConfidence IntervalsCritical CareCritical IllnessDose-Response Relationship, DrugDrug Administration ScheduleFemaleFollow-Up StudiesHIV InfectionsHospital MortalityHumansIntensive Care UnitsLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioProportional Hazards ModelsRetrospective StudiesRisk AssessmentSurvival AnalysisConceptsIntensive care unitAntiretroviral therapyICU admissionCare unitChronic Health Evaluation II scoreHuman immunodeficiency virus-infected patientsCD4 T-cell countUse of ARTTertiary care teaching hospitalMultivariate logistic regression analysisCox proportional hazards modelAcute illness severityRetrospective cohort studyT-cell countsVirus-infected patientsDay of admissionHuman immunodeficiency virusCause of admissionProportional hazards modelPotential confounding factorsLogistic regression analysisAcute PhysiologyICU mortalityII scoreCohort study