2020
Antimicrobial activity of plant extracts against carbapenem-producing Klebsiella pneumoniae and in vivo toxicological assessment
Vasconcelos N, Vaz M, Radai J, Kassuya C, Formagio A, Graciani F, Leal M, Oliveira R, da Silva K, Croda J, Simionatto S. Antimicrobial activity of plant extracts against carbapenem-producing Klebsiella pneumoniae and in vivo toxicological assessment. Journal Of Toxicology And Environmental Health Part A 2020, 83: 719-729. PMID: 32981476, DOI: 10.1080/15287394.2020.1824135.Peer-Reviewed Original ResearchConceptsSwiss male miceMultidrug-resistant strainsSplenic phagocytosisMale miceAgar disk diffusionBeneficial effectsToxicological assessmentMicronucleus assayKlebsiella pneumoniaePlant extractsVivo toxicological assessmentDisk diffusionAntibioticsAntimicrobial activityMutagenic activityGlobal spreadExtractMolecular characterizationAssessmentAntibacterial activityActivityMiceActive productsSynergismSynergistic effects of Cinnamomum cassia L. essential oil in combination with polymyxin B against carbapenemase-producing Klebsiella pneumoniae and Serratia marcescens
Vasconcelos N, de Sá Queiroz J, da Silva K, de Paula Vasconcelos P, Croda J, Simionatto S. Synergistic effects of Cinnamomum cassia L. essential oil in combination with polymyxin B against carbapenemase-producing Klebsiella pneumoniae and Serratia marcescens. PLOS ONE 2020, 15: e0236505. PMID: 32701970, PMCID: PMC7377461, DOI: 10.1371/journal.pone.0236505.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsBacterial ProteinsBeta-LactamasesCinnamomum aromaticumDrug Resistance, Multiple, BacterialDrug SynergismHumansKlebsiella InfectionsKlebsiella pneumoniaeOils, VolatilePolymyxin BSerratia InfectionsSerratia marcescensSpectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
2019
Origanum vulgare L. essential oil inhibits the growth of carbapenem-resistant gram-negative bacteria
Vasconcelos N, Croda J, Silva K, Motta M, Maciel W, Limiere L, Simionatto S. Origanum vulgare L. essential oil inhibits the growth of carbapenem-resistant gram-negative bacteria. Revista Da Sociedade Brasileira De Medicina Tropical 2019, 52: e20180502. PMID: 31271619, DOI: 10.1590/0037-8682-0502-2018.Peer-Reviewed Original ResearchConceptsCarbapenem-resistant strainsAlternative therapeutic optionTime-kill assaysMultidrug-resistant bacteriaTherapeutic optionsMinimum inhibitory concentrationAcinetobacter baumanniiCell countCarbapenemase productionKill assaysOriganum vulgare L. essential oilL. essential oilKlebsiella pneumoniaeInhibitory concentrationDrug developmentResistant bacteriaH treatmentSerratia marcescensAntimicrobial effectNegative bacteria