2018
The safe use of Doliocarpus dentatus in the gestational period: Absence of changes in maternal reproductive performance, embryo-fetal development and DNA integrity
Ishikawa R, Vani J, das Neves S, Rabacow A, Kassuya C, Croda J, Cardoso C, Monreal A, Antoniolli A, Cunha-Laura A, Oliveira R. The safe use of Doliocarpus dentatus in the gestational period: Absence of changes in maternal reproductive performance, embryo-fetal development and DNA integrity. Journal Of Ethnopharmacology 2018, 217: 1-6. PMID: 29408581, DOI: 10.1016/j.jep.2018.01.034.Peer-Reviewed Original ResearchConceptsFemale Swiss miceDoliocarpus dentatusSwiss miceEmbryofetal developmentGestational periodControl groupPregnant female Swiss miceEnd of pregnancyEmbryo-fetal developmentMaternal reproductive performanceReproductive performanceSafe useEmbryofoetal developmentUrinary retentionOral gavageAbsence of changesDNA integrityAntimycobacterial actionFetal developmentReproductive parametersFormation of micronucleiEthanolic extractPregnancySignificant differencesExperimental group
2014
Evaluation of the anti-mycobacterium tuberculosis activity and in vivo acute toxicity of Annona sylvatic
Araujo R, Neves F, Formagio A, Kassuya C, Stefanello M, Souza V, Pavan F, Croda J. Evaluation of the anti-mycobacterium tuberculosis activity and in vivo acute toxicity of Annona sylvatic. BMC Complementary Medicine And Therapies 2014, 14: 209. PMID: 24974069, PMCID: PMC4082671, DOI: 10.1186/1472-6882-14-209.Peer-Reviewed Original ResearchConceptsVivo acute toxicityAnti-mycobacterial activityLC-MSFirst chemical characterizationAnti-Mycobacterium tuberculosis activityLiquid-liquid partitioningMinimal inhibitory concentrationEthyl acetate fractionChemical characterizationAntituberculosis activitySpectroscopic dataBody weightIsolation of quercetinAcute toxicityChemical fractionationChromatographic analysisFemale Swiss miceMultidrug-resistant Mycobacterium tuberculosis strainsControl of tuberculosisAcute toxicity evaluationToxicity evaluationMycobacterium tuberculosis strainsTuberculosis activityAlmunequinEAF fractions