Judy Chen, MS, PA-C
Staff Affiliate - YNHHCards
About
Research
Publications
2024
iGATE analysis improves the interpretability of single-cell immune landscape of influenza infection
Hill B, Zak A, Raja S, Bugada L, Rizvi S, Roslan S, Nguyen H, Chen J, Jiang H, Ono A, Goldstein D, Wen F. iGATE analysis improves the interpretability of single-cell immune landscape of influenza infection. JCI Insight 2024, 9: e172140. PMID: 38814732, PMCID: PMC11383363, DOI: 10.1172/jci.insight.172140.Peer-Reviewed Original ResearchInfluenza infectionImmune cell typesCourse of influenza infectionDefective T cell responsesSurvival of C57BL/6 miceCell typesDecreased IL-10 expressionEffect of host genetic backgroundT cell responsesGenetic backgroundTime-of-flight (CyTOFIL-10 expressionInflammatory cell typesCells in silicoHost genetic backgroundC57BL/6 miceAged miceMouse lungHost genotypeInfection susceptibilityHost factorsEffects of ageMiceHealth burdenInfectionPublisher Correction: Clonally expanded memory CD8+ T cells accumulate in atherosclerotic plaques and are pro-atherogenic in aged mice
Tyrrell D, Wragg K, Chen J, Wang H, Song J, Blin M, Bolding C, Vardaman D, Giles K, Tidwell H, Ali M, Janappareddi A, Wood S, Goldstein D. Publisher Correction: Clonally expanded memory CD8+ T cells accumulate in atherosclerotic plaques and are pro-atherogenic in aged mice. Nature Aging 2024, 4: 1166-1166. PMID: 38789547, DOI: 10.1038/s43587-024-00653-9.Peer-Reviewed Original ResearchBiomarkers from subcutaneous engineered tissues predict acute rejection of organ allografts
Urie R, Morris A, Farris D, Hughes E, Xiao C, Chen J, Lombard E, Feng J, Li J, Goldstein D, Shea L. Biomarkers from subcutaneous engineered tissues predict acute rejection of organ allografts. Science Advances 2024, 10: eadk6178. PMID: 38748794, PMCID: PMC11095459, DOI: 10.1126/sciadv.adk6178.Peer-Reviewed Original ResearchConceptsGraft biopsyGraft injuryRag2<sup>-/-</sup> miceAdoptive transfer of T cellsTransfer of T cellsRejection of organ allograftsAcute cellular allograft rejectionCellular allograft rejectionEfficacy of immunosuppressionPredominant innate immune cellsInnate immune cellsRisk of rejectionWild-type animalsPersonalized immunosuppressionAdoptive transferAcute rejectionOrgan allograftsAllograft rejectionFrequent biopsiesT cellsImmune cellsTransplant rejectionImmunological nicheRespiratory infectionsInflammatory insult
2023
Clonally expanded memory CD8+ T cells accumulate in atherosclerotic plaques and are pro-atherogenic in aged mice
Tyrrell D, Wragg K, Chen J, Wang H, Song J, Blin M, Bolding C, Vardaman D, Giles K, Tidwell H, Ali M, Janappareddi A, Wood S, Goldstein D. Clonally expanded memory CD8+ T cells accumulate in atherosclerotic plaques and are pro-atherogenic in aged mice. Nature Aging 2023, 3: 1576-1590. PMID: 37996758, DOI: 10.1038/s43587-023-00515-w.Peer-Reviewed Original ResearchConceptsT cellsMemory CD8Aged miceAtherosclerotic plaquesDepletion of CD8Effector memory subsetsStrong risk factorT cell activationEnhanced atherosclerosisSplenic CD8Adoptive transferDonor miceMemory subsetsRecipient miceRisk factorsCD8Therapeutic targetCell activationAtherosclerosisSingle-cell RNA sequencingMiceTranscriptomic signaturesAtherogenesisPlaquesRNA sequencingTissue Engineering Scaffolds Remotely Surveil Presymptomatic Allograft Rejection
Urie R, Xiao C, Hughes E, Lombard E, Chen J, Morris A, Farris D, Goldstein D, Shea L. Tissue Engineering Scaffolds Remotely Surveil Presymptomatic Allograft Rejection. The Journal Of Immunology 2023, 210: 173.40-173.40. DOI: 10.4049/jimmunol.210.supp.173.40.Peer-Reviewed Original ResearchAcute cellular allograft rejectionEndomyocardial biopsyRisk of rejectionAllograft rejectionT cell-mediated rejectionRoutine endomyocardial biopsyCellular allograft rejectionHeterotopic heart transplantationMinimally-invasive samplingHealthy allograftsPersonalized immunosuppressionGraft biopsyPredictive biomarkersImmune suppressionHeart transplantationImmune cellsInvasive biopsyImmunological nicheHistological evidenceSkin transplantationBiopsyHistological evaluationGene profilesMolecular biomarkersPorous biomaterials
Clinical Care
Overview
Clinical Specialties
Surgical Oncology
Board Certifications
Physician Assistant - Surgical
- Certification Organization
- National Commission on Certification of Physician Assistants
- Original Certification Date
- 2011