Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy
Launer LJ, Miller ME, Williamson JD, Lazar RM, Gerstein HC, Murray AM, Sullivan M, Horowitz KR, Ding J, Marcovina S, Lovato LC, Lovato J, Margolis KL, O'Connor P, Lipkin EW, Hirsch J, Coker L, Maldjian J, Sunshine JL, Truwit C, Davatzikos C, Bryan RN, investigators F. Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy. The Lancet Neurology 2011, 10: 969-977. PMID: 21958949, PMCID: PMC3333485, DOI: 10.1016/s1474-4422(11)70188-0.Peer-Reviewed Original ResearchConceptsTotal brain volumeType 2 diabetesIntensive treatment groupIntensive treatmentStandard treatmentGlycaemic controlDSST scoresTreatment groupsBrain volumeDigit Symbol Substitution Test scoreHigher glycated hemoglobinIntensive glycaemic controlOpen-label substudyStandard glycaemic controlStandard treatment groupUS National HeartMonth outcome measuresSubset of participantsSignificant treatment differencesACCORD studyCardiovascular eventsCardiovascular riskIntensive glucoseBrain atrophyIntensive therapy