pH-weighted molecular imaging of gliomas using amine chemical exchange saturation transfer MRI
Harris R, Cloughesy T, Liau L, Prins R, Antonios J, Li D, Yong W, Pope W, Lai A, Nghiemphu P, Ellingson B. pH-weighted molecular imaging of gliomas using amine chemical exchange saturation transfer MRI. Neuro-Oncology 2015, 17: 1514-1524. PMID: 26113557, PMCID: PMC4648305, DOI: 10.1093/neuonc/nov106.Peer-Reviewed Original ResearchConceptsAmine chemical exchange saturation transferPH-weighted MRIShorter time to progressionAcid lesionsTime to progressionChemical exchange saturation transfer MRIMolecular imaging of gliomaIntracranial glioma modelBrain tumor physiologyImaging of gliomasActive tumorAbnormal perfusionGlioma modelPerfusion abnormalitiesGlioblastoma patientsMolecular imaging techniquesPET uptakeTumor physiologyMR spectroscopyTissue acidosisChemical exchange saturation transferHuman patientsPatientsTumorLesions